43066-Lee, Do Hun

Do Hun Lee, PhD, MS

Research Associate in Neurological Surgery

NB 108B
Indianapolis, IN

Key Publications

Peer reviewed publication (with 11 first author papers)

1. Zhu Y, Lyapichev K, Lee DH, Motti D, Ferraro NM, Zhang Y, Yahn S, Soderblom C, Zha J, Bethea JR, Spiller KL, Lemmon VP, Lee JK. Macrophage Transcriptional Profile Identifies Lipid Catabolic Pathways That Can Be Therapeutically Targeted after Spinal Cord Injury. J Neurosci. 2017 Mar 1;37(9):2362-2376. https://www.ncbi.nlm.nih.gov/pubmed/?term=28130359

2. Luo X, Ribeiro M, Bray ER, Lee DH, Yungher BJ, Mehta ST, Thakor KA, Diaz F, Lee JK, Moraes CT, Bixby JL, Lemmon VP, Park KK. Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System. Cell Rep. 2016 Apr 12;15(2):398-410. https://www.ncbi.nlm.nih.gov/pubmed/?term=27050520

3. Hackett A, Lee DH*, Dawood A, Rodriguez M, Funk L, Tsoulfas P, and Lee JK. STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury. Neurobiol Dis. 2016 May;89:10-22. (*: equal contributor). http://www.ncbi.nlm.nih.gov/pubmed/26804026

4. Al-Ali H, Lee DH, Danzi MC, Nassif H1, Gautam P, Wennerberg K, Zuercher B, Drewry DH, Lee JK, Lemmon VP, Bixby JL. Rational polypharmacology: systematically identifying and engaging multiple drug targets to promote axon growth. ACS Chem Biol. 2015 Aug 21;10(8):1939-51. http://www.ncbi.nlm.nih.gov/pubmed/26056718

5. Zhu Y, Soderblom C, Trojanowsky M, Lee DH, Lee JK. Fibronectin Matrix Assembly after Spinal Cord Injury. J Neurotrauma. 2015 Aug 1;32(15):1158-67. http://www.ncbi.nlm.nih.gov/pubmed/25492623

6. Soderblom C*, Lee DH*, Dawood A, Carballosa M, Santamaria AJ, Benavides FD, Jergova S, Grumbles RM, Thomas CK, Park KK, Guest JD, Lemmon VP, Lee JK, Tsoulfas P. 3D Imaging of Axons in Transparent Spinal Cords from Rodents and Nonhuman Primates. eNeuro 2015 Mar; 2(2) (*: equal contributor). http://www.ncbi.nlm.nih.gov/pubmed/26023683

7. Lee DH, Luo X, Yungher BJ, Bray E, Lee JK, Park KK. Mammalian target of rapamycin's distinct roles and effectiveness in promoting compensatory axonal sprouting in the injured CNS. J Neurosci. 2014 Nov 12;34(46):15347-55. http://www.ncbi.nlm.nih.gov/pubmed/25392502

8. Hwang DW, Jin Y, Lee DH, Kim HY, Cho HN, Chung HJ, Park Y, Youn H, Lee SJ, Lee HJ, Kim SU, Wang KC, Lee DS. In vivo bioluminescence imaging for prolonged survival of transplanted human neural stem cells using 3D biocompatible scaffold in corticectomized rat model. PLoS One. 2014 Sep 8;9(9):e105129. http://www.ncbi.nlm.nih.gov/pubmed/25198726

9. Lee JY, Lee DH, Kim HA, Choi SA, Lee HJ, Park CK, Phi JH, Wang KC, Kim SU, Kim SK. Double suicide gene therapy using human neural stem cells against glioblastoma: double safety measures. J Neurooncol. 2014 Jan;116(1):49-57. http://www.ncbi.nlm.nih.gov/pubmed/24113876

10. Lee DH, Lee JK. Animal models of axon regeneration after spinal cord injury. Neurosci Bull. 2013 Aug;29(4):436-44. http://www.ncbi.nlm.nih.gov/pubmed/23893429

11. Yang HJ, Lee DH, Lee YJ, Chi JG, Lee JY, Phi JH, Kim SK, Cho BK, Wang KC. Secondary neurulation of human embryos: morphological changes and the expression of neuronal antigens. Childs Nerv Syst. 2014 Jan;30(1):73-82. http://www.ncbi.nlm.nih.gov/pubmed/23760472

12. Lee DH, Lee JY, Oh BM, Phi JH, Kim SK, Bang MS, Kim SU, Wang KC. Functional recovery after injury of motor cortex in rats: effects of rehabilitation and stem cell transplantation in a traumatic brain injury model of cortical resection. Childs Nerv Syst. 2013 Mar;29(3):403-11. http://www.ncbi.nlm.nih.gov/pubmed/23180314

13. Lim SH, Choi SA, Lee JY, Wang KC, Phi JH, Lee DH, Song SH, Song JH, Jin X, Kim H, Lee HJ, Lim I, Kim SU, Kim SK. Therapeutic targeting of subdural medulloblastomas using human neural stem cells expressing carboxylesterase. Cancer Gene Ther. 2011 Nov;18(11):817-24. http://www.ncbi.nlm.nih.gov/pubmed/21869821

14. Choi SA, Hwang SK, Wang KC, Cho BK, Phi JH, Lee JY, Jung HW, Lee DH, Kim SK. Therapeutic efficacy and safety of TRAIL-producing human adipose tissue-derived mesenchymal stem cells against experimental brainstem glioma. Neuro Oncol. 2011 Jan;13(1):61-9. http://www.ncbi.nlm.nih.gov/pubmed/21062796

15. Lee DH, Phi JH, Kim SK, Cho BK, Kim SU, Wang KC. Enhanced reclosure of surgically induced spinal open neural tube defects in chick embryos by injecting human bone marrow stem cells into the amniotic cavity. Neurosurgery. 2010 Jul;67(1):129-35. http://www.ncbi.nlm.nih.gov/pubmed/20559100

16. Lee DH, Phi JH, Chung YN, Lee YJ, Kim SK, Cho BK, Kim DW, Park MS, Wang KC. Expression of neuronal antigens and related ventral and dorsal proteins in the normal spinal cord and a surgically induced open neural tube defect of the spine in chick embryos: an immunohistochemical study. Childs Nerv Syst. 2010 May;26(5):627-36. http://www.ncbi.nlm.nih.gov/pubmed/19949802

17. Lee DH, Hong SH, Kim SK, Lee CS, Phi JH, Cho BK, Wang KC. Reproducible and persistent weakness in adult rats after surgical resection of motor cortex: evaluation with limb placement test. Childs Nerv Syst. 2009 Dec;25(12):1547-53. http://www.ncbi.nlm.nih.gov/pubmed/19701642

18. Lee DH, Ahn Y, Kim SU, Wang KC, Cho BK, Phi JH, Park IH, Black PM, Carroll RS, Lee J, Kim SK. Targeting rat brainstem glioma using human neural stem cells and human mesenchymal stem cells. Clin Cancer Res. 2009 Aug 1;15(15):4925-34. http://www.ncbi.nlm.nih.gov/pubmed/19638465

19. Phi JH, Park SH, Kim SK, Paek SH, Kim JH, Lee YJ, Cho BK, Park CK, Lee DH, Wang KC. Sox2 expression in brain tumors: a reflection of the neuroglial differentiation pathway. Am J Surg Pathol. 2008 Jan;32(1):103-12. http://www.ncbi.nlm.nih.gov/pubmed/18162777

20. Chung YN, Lee DH, Yang HJ, Kim SK, Lee YJ, Lee MS, Cho BK, Kim DH, Wang KC. Expression of neuronal markers in the secondary neurulation of chick embryos. Childs Nerv Syst. 2008 Jan;24(1):105-10. http://www.ncbi.nlm.nih.gov/pubmed/17805548

21. Park JP, Kim KJ, Phi JH, Park CK, Kim JH, Kang HJ, Lee D, Han KH, Wang KC, Paek SH. Simple measurement of spinal cord evoked potential: A valuable data source in the rat spinal cord injury model. J Clin Neurosci. 2007 Nov;14(11):1099-105. http://www.ncbi.nlm.nih.gov/pubmed/17719789

22. Phi JH, Park SH, Paek SH, Kim SK, Lee YJ, Park CK, Cho BK, Lee DH, Wang KC. Expression of Sox2 in mature and immature teratomas of central nervous system. Mod Pathol. 2007 Jul;20(7):742-8. http://www.ncbi.nlm.nih.gov/pubmed/17464316
23. Lee DH, Kim EY, Park S, Phi JH, Kim SK, Cho BK, Lim J, Wang KC. Reclosure of surgically induced spinal open neural tube defects by the intraamniotic injection of human embryonic stem cells in chick embryos 24 hours after lesion induction. J Neurosurg. 2006 Aug;105(2 Suppl):127-33. http://www.ncbi.nlm.nih.gov/pubmed/16922074

24. Lee DH, Park S, Kim EY, Kim SK, Chung YN, Cho BK, Lee YJ, Lim J, Wang KC. Enhancement of re-closure capacity by the intra-amniotic injection of human embryonic stem cells in surgically induced spinal open neural tube defects in chick embryos. Neurosci Lett. 2004 Jul 1;364(2):98-100. http://www.ncbi.nlm.nih.gov/pubmed/15196686

Titles & Appointments

  • Research Associate in Neurological Surgery
  • Education
    2010 PhD Seoul National University
    2005 MS Seoul National University
    2003 BS Daejeon University
  • Professional Organizations
    Korean-American Scientists and Engineers Association (KSEA)
    Society for Neuroscience
  • Awards
    Org: 10th Anniversary of the Korean Society for Brain and Neural Science Annual Meeting
    Desc: Best Poster Award
    Scope: National
    Org: Korea Student Aid Foundation
    Desc: National Research Fellowship for Science and Engineering
    Scope: National
    Org: 2010 Association of Korean Neuroscientists Meeting
    Desc: AKN Outstanding Research Award
    Scope: National

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