Monte S. Willis, MD PhD, MBA
Professor of Pathology & Laboratory Medicine
1. Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16. PLOS Genetics, in press.
2. Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the Muscle Ring Finger-1 (MuRF1) ubiquitin ligase in vivo. BMC Med Genetics, in press.
3. Image-based methods for phase estimation, gating and temporal super-resolution of cardiac ultrasound. IEEE Trans Biomed Eng, in press.
1.Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP. J. Cardiovasc. Dev. Dis. 2018, 5(3), 43.
2. The Role of Heat Shock Proteins and Co-Chaperones in Heart Failure. Philos Trans R Soc Lond B Biol Sci. 2018;373(1738).
3. Leading Mindfully and Managing Compassionately: Strategies for Meeting Today’s Challenges in Pathology Academic Medicine. International Journal of Academic Medicine. 2018 4(1): 12-20.
4. Early Stages of the Cardiac Fuel Switch: Modeling the Transition from Physiological to Pathological Hypertrophy. J Am Heart Assoc. 2018;7(8).
5. Cardiovascular Health in African Americans: A Scientific Statement from the American Heart Association (endorsed by the American College of Cardiology). Circulation. 2017;136(21):e393-e423.
Titles & Appointments
- Professor of Medicine
- Deputy Director, Indiana University Center for Musculoskeletal Health
- Vice-Chair of Research, Department of Pathology & Laboratory Medicine
- Adjunct Professor, Krannert Cardiology Institute
- Identifying the role of muscle-specific ubiquitin ligases (MuRF proteins) in regulating cell signaling and metabolism by regulating nuclear receptors
- Determining how muscle-specific ubiquitin ligases degrade inherited mutant muscle proteins (e.g., cMyBP-C and BAG3 proteins) in the pathogenesis of heart failure
- Discovery of mechanisms and therapies for Bag3 P209L myofibrillar myopathy (MFM).
Research Program Links:
The Indiana Center for Musculoskeletal Health harnesses the exceptional scientific talent already in place, in conjunction with new recruited talent, toward the discovery and development of new treatments, cures, preventative strategies, diagnostic tools, and technologies to address the increasing burden of bone, muscle and cartilage disorders among patients of all ages. The center aspires to be an international leader in basic and translational musculoskeletal disease research, clinical research, trials and treatment, and in musculoskeletal education.
Myofibrillar Myopathy (Bag3 P209L) Foundations / Friends supporting our work: Alexander's Way Foundation Scientific Advisory Board Moerae Matrix, LLC
American Physiological Society, Cardiovascular Section, Endocrinology & Metabolism Section
American Society for Investigative Pathology (ASIP) (Council Member)
American Society of Clinical Pathology (Fellow)
Association for European Cardiovascular Pathology
Association of Pathology Chairs (APC)
College of American Pathologists (Fellow)
International Society for Heart Research (North American Section Council Member)
Society for Cardiovascular Pathology (Previous Council Member)
United States & Canadian Academy of Pathology
Desc: Cotran Early Career Investigator Award
Desc: Jefferson-Pilot Fellowship in Academic Medicine