Roland W. Herzog

Roland W. Herzog, PhD

Riley Children's Foundation Professor of Immunology


Roland W. Herzog, PhD, is a Professor of Pediatrics, Riley Children's Foundation Professor of Immunology, and Director of the Gene and Cell Therapy Program. His research interests are in gene therapy and immune tolerance for hemophilia and in AAV vectors. He received a PhD in Microbiology from Auburn University in 1996, followed by postdoctoral training at the Children’s Hospital of Philadelphia and faculty appointment at the University of Pennsylvania, before joining the University of Florida in 2005 and then Indiana University in 2018. Dr. Herzog received multiple awards for his research from the American Society of Gene and Cell Therapy, the National Hemophilia Foundation, the Bayer Hemophilia Program, and the University of Florida Research Foundation, among others. He currently serves as editor-in-chief of Molecular Therapy Methods & Clinical Development. Dr. Herzog’s work is supported by multiple grants from the National Institutes of Health.

Key Publications

Rogers GL, Shirley JL, Zolotukhin I, Kumar SRP, Sherman A, Perrin GQ, Hoffman BE, Srivastava A, Basner-Tschakarjan E, Wallet M, Terhorst C, Biswas M, Herzog RW (2017) Plasmacytoid and conventional dendritic cells cooperate to cross-prime AAV capsid-specific CD8+T cells. Blood 129: 3184-3195


Sherman A, Su J, Lin S, Wang X, Herzog RW, Daniell H (2014) Suppression of inhibitor formation against FVIII in a murine model of hemophilia A by oral delivery of antigens bioencapsulated in plant cells. Blood 124:1659-1668


Markusic DW, Hoffman BE, Perrin GQ, Nayak S, Wang X, LoDuca PA, High KA, Herzog RW (2013) Effective gene therapy for hemophilic mice with pathogenic factor IX antibodies. EMBO Mol. Med. 5: 1698-1709


Cao O, Dobrzynski E, Wang L, Nayak S, Mingle B, Terhorst C, Herzog RW (2007) Induction and role of regulatory CD4+CD25+T cells in tolerance to the transgene product following hepatic in vivo gene transfer. Blood 110: 1132-1140


Mingozzi F, Liu YL, Dobrzynski E, Kaufhold A, Liu JH, Wang YQ, Arruda VR, High KA, Herzog RW (2003) Induction of immune tolerance to coagulation factor IX antigen by in vivohepatic gene transfer. J. Clin. Invest. 111: 1347-1356


Herzog RW, Yang EY, Hagstrom JN, Couto LB, Elwell D, Fields PA, Burton M, Bellinger DA, Read MS, Brinkhous KM, Podsakoff GM, Nichols TC, Kurtzman GJ, High KA (1999) Long-term phenotypic correction of canine hemophilia B by AAV-mediated gene transfer of blood coagulation factor IX. Nat Med 5: 56-63


Ped Basic Research
R4 108 PIMB
Indianapolis, IN


Translational Research

Titles & Appointments

  • Professor of Pediatrics
  • Professor of Microbiology & Immunology
  • Director, Gene and Cell Therapy Program