39074-Misra, Jagannath

Jagannath Misra, PhD

Assistant Research Professor of Biochemistry & Molecular Biology

Phone
(317) 274-0914
Address
MS 4053
BIOM
IN
Indianapolis, IN
PubMed:

Bio

Dr. Misra is an Assistant Research Professor of biochemistry and studies how cells cope with stress. This research is important for creating new approaches aimed at diagnosing and treating diabetes and related metabolic disorders, skin disorders, infectious diseases, cancers, and neuropathologies.

With a PhD from Chonnam National University, South Korea and postdoctoral training from Indiana University School of Medicine, Dr. Misra is an accomplished biochemist and molecular biologist. Dr. Misra's area of expertise centers around examining how cells manage stress, which encompasses nutrient deprivation and disruptions in protein folding. This research has revealed stress recognition pathways and gene expression programs that are specifically designed to help cells adapt to stress, and elucidates the underlying mechanisms that contribute to both health and disease. Importantly, this work has significant implications for developing innovative approaches to diagnose and treat various medical conditions, such as diabetes, metabolic disorders, skin disorders, infectious diseases, cancers, and neuropathologies.

Key Publications

Srivastava S, Jiang J, Misra J, Seim G, Staschke KA, Zhong M, Zhou L, Liu Y, Chen C, Davé U, Kapur R, Batra S, Zhang C, Zhou J, Fan J, Wek RC, Zhang J. Asparagine bioavailability regulates the translation of MYC oncogene. Oncogene. 2022 Oct;41(44):4855-4865. doi: 10.1038/s41388-022-02474-9. Epub 2022 Oct 1. PubMed PMID: 36182969; PubMed Central PMCID: PMC9617787.

Cordova RA, Misra J, Amin PH, Klunk AJ, Damayanti NP, Carlson KR, Elmendorf AJ, Kim HG, Mirek ET, Elzey BD, Miller MJ, Dong XC, Cheng L, Anthony TG, Pili R, Wek RC, Staschke KA. GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis. Elife. 2022 Sep 15;11. doi: 10.7554/eLife.81083. PubMed PMID: 36107759; PubMed Central PMCID: PMC9578714.

Holmes MJ, Misra J, Wek RC. Analysis of Translational Control in the Integrated Stress Response by Polysome Profiling. Methods Mol Biol. 2022;2428:157-171. doi: 10.1007/978-1-0716-1975-9_10. PubMed PMID: 35171479.

Misra J, Holmes MJ, T Mirek E, Langevin M, Kim HG, Carlson KR, Watford M, Dong XC, Anthony TG, Wek RC. Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress. Nucleic Acids Res. 2021 Jun 4;49(10):5726-5742. doi: 10.1093/nar/gkab362. PubMed PMID: 34023907; PubMed Central PMCID: PMC8191763.

Misra J, Kim DK, Choi HS. ERRγ: a Junior Orphan with a Senior Role in Metabolism. Trends Endocrinol Metab. 2017 Apr;28(4):261-272. doi: 10.1016/j.tem.2016.12.005. Epub 2017 Feb 14. Review. PubMed PMID: 28209382.

Misra J, Kim DK, Jung YS, Kim HB, Kim YH, Yoo EK, Kim BG, Kim S, Lee IK, Harris RA, Kim JS, Lee CH, Cho JW, Choi HS. O-GlcNAcylation of Orphan Nuclear Receptor Estrogen-Related Receptor γ Promotes Hepatic Gluconeogenesis. Diabetes. 2016 Oct;65(10):2835-48. doi: 10.2337/db15-1523. Epub 2016 Jun 22. PubMed PMID: 27335230.

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