Christopher M. Robinson, PhD

Enteric viruses initiate infection in the diverse environment of the gastrointestinal tract, yet the impact of this environment on intestinal infection is unclear. Research in the Robinson lab focuses on the complex methods in which enteric viruses traverse the intestinal environment to initiate infection. Specifically, we are interested in identifying intestinal factors that influence viral replication. By characterizing intestinal factors that alter enteric viral virulence, potential therapeutic targets may be identified.

The Robinson lab currently focuses on two major areas of research:

1. Using coxsackievirus, a model enteric virus, we study how biological sex can influence viral replication in the intestine. Using an oral-inoculated mouse model, we found that, similar to humans, male mice succumb to coxsackievirus-induced disease, whereas females do not. Additionally, coxsackievirus replication in the intestine of male mice is enhanced and may be regulated by sex hormones. Our current studies are focused on using in vitro and in vivo approaches to determine the mechanism behind sex-dependent replication and pathogenesis of coxsackievirus.

2. The intestine is home to a large community of bacteria that are vital for human health. Emerging data suggest that intestinal bacteria enhance replication and pathogenesis of enteric viruses, yet the mechanism of these interactions remain unclear. The Robinson lab is interested in understanding the mechanisms and consequences of the interactions between intestinal bacteria and enteric viruses using coxsackievirus and other picornaviruses as a model.