26956-Zang, Yong
Faculty

Yong Zang, PhD

Associate Professor of Biostatistics & Health Data Science

Phone (317) 278-2108
Address
HITS 5023
BSAT
IN
Indianapolis, IN
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Key Publications

Recent Methdological Publications († for corresponding author, ‡ for supervised student):
  1. Zang Y†, Thall P and. Yuan Y. A generalized phase 1-2-3 design integrating dose optimization with confirmatory treatment comparison. Biometrics accepted, 2023+.
  2. Park J, Hu W, Jin IH, Liu H and Zang Y†. A Bayesian adaptive biomarker stratified phase II randomized clinical trial design for radiotherapies with competing risks survival outcomes. Statistical Methods in Medical Research in press, 2023+.
  3. Zang Y†, Guo B, Qiu Y‡, Liu H, Opyrchal M and Lu X. Adaptive phase I-II clinical trial designs identifying optimal biological doses for targeted agents and immunotherapies. Clinical Trials accepted, 2023+. (Invited review paper)
  4. Chen W‡, Ding Z, Zang Y and Liu X. Characterization of proteoform post-translational modifications by top-down and bottom-up mass spectrometry in conjunction with UniProt annotations. Journal of Proteome Research 22: 3178-3189, 2023.
  5. Thall P, Zang Y, Chapple AG, Yuan Y, Lin R, Marin D and Msaouel P. Novel clinical trial designs that optimize dose to improve long-term outcomes. Clinical Cancer Research 29: 4549-4554, 2023.
  6. Basharat AR‡, Zang Y, Sun L and Liu X. TopFD: A proteoform feature detection tool for top-down proteomics. Analytical Chemistry 95: 8189-8196, 2023.
  7. Thall P, Zang Y and Yuan Y. Generalized phase I-II designs to increase long term therapeutic success rate. Pharmaceutical Statistics 22: 692-706, 2023.
  8. Qiu Y‡, Zhao Y, Liu H, Cao S, Zhang C and Zang Y†. Modified isotonic regression based phase I/II clinical trial design identifying optimal biological dose. Contemporary Clinical Trials 127: 107139, 2023.
  9. Shan M‡, Guo B, Liu H, Li Q and Zang Y†. Bayesian order constrained adaptive design for phase II clinical trials evaluating subgroup-specific treatment effect. Statistical Methods in Medical Research 32: 885-894, 2023.
  10. Guo B, Zang Y, Lin H and Zhang R. A Bayesian phase I/II design to determine subgroup-specific optimal dose for immunotherapy sequentially combined with radiotherapy. Pharmaceutical Statistics 22: 143-161, 2023.
  11. Chen W‡, McCool E, Sun L, Zang Y, Ning X, Liu, X. Evaluation of machine learning models for proteoform retention and migration time prediction in top-down mass spectrometry. Journal of Proteome Research 21: 1736-1747, 2022.
  12. Zhang Y‡, Guo B, Cao S, Zhang C and Zang Y†. SCI: A Bayesian adaptive phase I/II dose-finding design accounting for semi-competing risks outcomes for immunotherapy trials. Pharmaceutical Statistics 21: 960-973, 2022.
  13. Guo B and Zang Y. A Bayesian phase I/II biomarker-based design for identifying subgroup-specific optimal dose for immunotherapy. Statistical Methods in Medical Research 31: 1104-1119, 2022.
  14. Guo B and Zang Y. BIPSE: A biomarker-based phase I/II design for immunotherapy trials with progression-free survival endpoint. Statistics in Medicine 41: 1205-1224, 2022.
  15. Chen Z and Zang Y†. CMAX3: A robust statistical test for genetic association accounting for covariates. Genes 12: 1723, 2021.
  16. Zhang Y‡ and Zang Y†. CWL: A conditional weighted likelihood method to account for the delayed joint toxicity-efficacy outcomes for phase I/II clinical trials. Statistical Methods in Medical Research 30: 892-903, 2021.
  17. Han Y, Liu H, Cao S, Zhang C and Zang Y†. TSNP: a two-stage nonparametric phase I/II clinical trial design for immunotherapy. Pharmaceutical Statistics 20: 282-296, 2021.
  18. Guo B and Zang Y. BILITE: A Bayesian phase II design for immunotherapy by jointly modeling the longitudinal immune response and time-to-event efficacy. Statistics in Medicine 39: 4439-4451, 2021.
  19. Zhang Y‡, Cao S, Zhang C, Jin IH and Zang Y†. A Bayesian adaptive phase I/II clinical trial design with late-onset competing risk outcomes. Biometrics 77: 796-808, 2021 (Top cited article 2020-2021, 2021-2022).

Titles & Appointments

  • Associate Professor of Biostatistics & Health Data Science
  • Adjunct Associate Professor, School of Informatics and Computing
  • Adjunct Associate Professor, School of Public Health
  • Education
    2011 PhD University of Hong Kong
    2007 MS University of Science and Technology of China
    2004 BS Anhui University
  • Research

    Theory, algorithm and software development for adaptive clinical trial design and analysis; statistical genetics; Bayesian analysis

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