Matthew D. Durbin, MD
Assistant Professor of Clinical Pediatrics
Dr. Durbin is an Assistant Professor of Clinical Pediatrics at Indiana University School of Medicine. He received his undergraduate degree from Indiana University and did his medical training at Wright State University. After medical school, Dr. Durbin completed a residency in pediatrics at the Loyola University Chicago and a fellowship in Neonatal-Perinatal Medicine at Vanderbilt University in Nashville. He is an attending neonatologist providing clinical service in the ICU and CVICU at the Riley Hospital for Children, Eskenazi Hospital, and St. Francis Hospital in Indianapolis. He is also a basic scientist at the Wells Center for Pediatric Research, focusing on the genomics and developmental defects leading to congenital heart disease.
1) Denver D, Feinberg S, Steding C, Durbin M, and Lynch, M. The relative roles of three DNA repair pathways in preventing Caenorhabditis elegans mutation accumulation. Genetics 174.1 (2006): 57-65.
2) Michail S, Durbin M, Turner D, Griffiths A, Mack D, Hyams J, Leleiko N, Kenche H, Stolfi A, Wine E. Alterations in the gut microbiome of children with severe ulcerative colitis. Inflammatory Bowel Diseases 18.10 (2012): 1799-1808.
3) Durbin, M. D., Cadar, A. G., Williams, C. H., Guo, Y., Bichell, D. P., Su, Y. R., & Hong, C. C. (2017). Hypoplastic Left Heart Syndrome Sequencing Reveals a Novel NOTCH1 Mutation in a Family with Single Ventricle Defects. Pediatric Cardiology, 1-9.
4) Cadar, A. G.*, Feaster, T. K.*, Durbin, M. D.*, & Hong, C. C. (2017). Production of Single Contracting Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Matrigel Mattress Technique. Current Protocols in Stem Cell Biology, 4A-14. *Authors contributed equally to publication.
1044 W. Walnut Street R4 221
Indianapolis, IN 46202
Congenital heart disease is the most common birth defect, and a leading cause of death in the newborn period, yet etiology remains mostly unknown. During Neonatology Fellowship he used next generation sequencing and disease modeling with patient derived induced pluripotent stem cells to study the genetics and mechanism of congenital heart disease. After Fellowship Dr. Durbin joined the faculty at Indiana University and the lab of Dr. Stephanie Ware. He is using genomics, gene editing, animal models, and cell culture models to elucidate the developmental pathways and molecular mechanisms altered in structural heart disease. He is currently exploring the role of a gene called SHROOM3 in structural heart disease. He is also exploring the optimal clinical evaluation for newborns with heart disease in the ICU, including diagnostic testing using next generation sequencing, and whole exome sequencing.
Society for Pediatric Research