Peter C. Hollenhorst, PhD
Associate Professor of Biochemistry & Molecular Biology, Medical Sciences Program
Hollenhorst Lab Website
Dr. Hollenhorst’s research focuses on the mechanisms that allow genome sequence to dictate the transcriptional control of gene expression. A major goal of our laboratory is to understand how specificity is achieved in “families” of transcription factors that have homologous DNA binding domains. In particular we focus on the ETS family of oncogenic transcription factors. Chromosomal abnormalities involving ETS transcription factors are found in prostate cancer, Ewing’s sarcoma, and leukemia. Therefore it is critical to understand how some family members, but not others, promote cancer so that specific therapeutics can be developed. We use a wide variety of approaches ranging from biochemistry to genomics to study the interaction of ETS proteins with the genome and to determine the role these mechanisms play in carcinogenesis.
Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma.
An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer.
Comparison of MAPK specificity across the ETS transcription factor family identifies a high-affinity ERK interaction required for ERG function in prostate cells.
Extracellular signal-regulated kinase signaling regulates the opposing roles of JUN family transcription factors at ETS/AP-1 sites and in cell migration.
Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation.
The ETS gene ETV4 is required for anchorage-independent growth and a cell proliferation gene expression program in PC3 prostate cells.
Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors.
The GNUMAP algorithm: unbiased probabilistic mapping of oligonucleotides from next-generation sequencing.
Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family.
Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors.
Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation.
Forkhead genes in transcriptional silencing, cell morphology and the cell cycle. Overlapping and distinct functions for FKH1 and FKH2 in Saccharomyces cerevisiae.
Society for Basic Urology Research