Amelia K. Linnemann, PhD
Assistant Professor of Pediatrics
Dr. Linnemann recently established her research program as an Assistant Professor in the Herman B Wells Center for Pediatric Research at Indiana University School of Medicine. In addition to numerous awards throughout her career Dr. Linnemann is currently funded by a prestigious K01 Career Development Award from the National Institutes of Health (NIH). The primary focus of the Linnemann laboratory is to understand mechanisms of pancreatic β-cell death/survival, islet compensatory adaptation to cellular stress, and how these factors contribute to diabetes pathogenesis.
Titles & Appointments
- Adjunct Assistant Professor of Anatomy, Cell Biology & Physiology
- Adjunct Assistant Professor of Biochemistry & Molecular Biology
Research in the Linnemann lab is focused on diabetes; specifically the study of the insulin producing pancreatic beta-cells under conditions of inflammatory stress. The beta-cells must adapt rapidly to changing conditions in the body in order to maintain blood glucose within a normal range. When pancreatic islets are exposed to additional stress and demand due to factors such as inflammation or obesity, some beta-cells are better able to adapt and respond in such a way that allows them to survive. An inability to adapt contributes significantly to the development of diabetes. Thus, we are particularly interested in how higher level metabolic signals contribute to molecular crosstalk within the islet and influence beta-cell adaptation to stress. In an effort to develop therapies that prevent beta-cell failure in type 1 and type 2 diabetes, projects in the lab are focused on 3 major areas:
American Diabetes Association