Bryan K. Yamamoto, PhD
Chair, Department of Pharmacology & Toxicology
Dr. Yamamoto was an Assistant and Associate Professor with tenure in the Department of Pharmacology at the Northeastern Ohio Universities College of Medicine. Subsequently, he was Professor and Director of the Program in Basic and Clinical Neurosciences in the Department of Psychiatry at Case Western Reserve University School of Medicine before moving to Boston University School of Medicine as Professor and Director of the Laboratory of Neurochemistry in the Department of Pharmacology. In 2008, he joined the Department of Neurosciences at the University of Toledo College of Medicine as Chair and Professor.In 2015, he was appointed the Chair of the Department of Pharmacology and Toxicology and the Robert B. Forney Professor of Toxicology at the Indiana University School of Medicine. Dr. Yamamoto has served and continues to serve as a regular and ad hoc member of NIH Study Sections and is a member of several advisory boards of NIH-sponsored research centers and programs. He also is on the editorial boards of several journals.
Titles & Appointments
- Robert B. Forney Professor of Toxicology
- Professor of Pharmacology & Toxicology
Research in his lab has focused on how drugs of abuse affect the neurochemistry of brain. His research has been funded continuously by the National Institutes of Health. He has studied how amphetamines and their interaction with stress alterbrain function and produce damage to regions of the brain that are critically involved in controlling movement and memory processes. More specifically, he is interested in how oxidative, mitochondrial, inflammatory and excitatory processes converge to damage the dopamine and serotonin systems in the brain and how antagonism of these processes are mitigate their neurodegenerative effects. His laboratory also demonstrated that stress and the peripheral inflammatory effects of drugs of abuse mediate its neurotoxicity independent of the direct action of methamphetamine on the brain.
3,4-methylenedioxymethamphetamine increases excitability in the dentate gyrus: role of 5HT2A receptor-induced PGE2 signaling.
Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol-preferring rats.
MDMA-induced loss of parvalbumin interneurons within the dentate gyrus is mediated by 5HT2A and NMDA receptors.
Cyclooxygenase activity contributes to the monoaminergic damage caused by serial exposure to stress and methamphetamine.
Effect of repeated exposure to MDMA on the function of the 5-HT transporter as assessed by synaptosomal 5-HT uptake.
MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase.
Persistent neuroinflammatory effects of serial exposure to stress and methamphetamine on the blood-brain barrier.
Alterations in adult behavioral responses to cocaine and dopamine transporters following juvenile exposure to methamphetamine.
Chronic stress enhances the corticosterone response and neurotoxicity to +3,4-methylenedioxymethamphetamine (MDMA): the role of ambient temperature.
Regulation of glutamate release by a7 nicotinic receptors: differential role in methamphetamine-induced damage to dopaminergic and serotonergic terminals.
Serotonin 2 receptor modulation of hyperthermia, corticosterone, and hippocampal serotonin depletions following serial exposure to chronic stress and methamphetamine.
MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning.
Repeated exposure to MDMA provides neuroprotection against subsequent MDMA-induced serotonin depletion in brain.
Chronic unpredictable stress augments +3,4-methylenedioxymethamphetamine-induced monoamine depletions: the role of corticosterone.
Chronic stress enhances methamphetamine-induced extracellular glutamate and excitotoxicity in the rat striatum.
The role of oxidative stress, metabolic compromise, and inflammation in neuronal injury produced by amphetamine-related drugs of abuse.
Actions of 3,4-methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons.
Haloperidol treatment after high-dose methamphetamine administration is excitotoxic to GABA cells in the substantia nigra pars reticulata.
Effects of chronic unpredictable stress on monoamine transporter immunoreactivity and methamphetamine-induced dopamine release in the nucleus accumbens shell.
Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release.
A rapid oxidation and persistent decrease in the vesicular monoamine transporter 2 after methamphetamine.
Augmentation of methamphetamine-induced toxicity in the rat striatum by unpredictable stress: contribution of enhanced hyperthermia.
Interactions between methamphetamine and environmental stress: role of oxidative stress, glutamate and mitochondrial dysfunction.
Dopaminergic and GABAergic modulation of glutamate release from rat subthalamic nucleus efferents to the substantia nigra.
Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor.
Effects of subchronic methamphetamine exposure on basal dopamine and stress-induced dopamine release in the nucleus accumbens shell of rats.
Methamphetamine-induced inhibition of mitochondrial complex II: roles of glutamate and peroxynitrite.
Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain.
Clozapine prolongs hypotonic immobility in rats with bilateral 6-hydroxydopamine lesions of the striatum.
Tyrosine augments clozapine-induced dopamine release in the medial prefrontal cortex of the rat in vivo: effects of access to food.
High-dose methamphetamine acutely activates the striatonigral pathway to increase striatal glutamate and mediate long-term dopamine toxicity.
Lobeline attenuates methamphetamine-induced changes in vesicular monoamine transporter 2 immunoreactivity and monoamine depletions in the striatum.
Pharmacokinetics of systemically administered tyrosine: a comparison of serum, brain tissue and in vivo microdialysate levels in the rat.
Catecholaminergic microcircuitry controlling the output of airway-related vagal preganglionic neurons.
Altered forebrain neurotransmitter responses to immobilization stress following 3,4-methylenedioxymethamphetamine.
Tyrosine augments acute clozapine- but not haloperidol-induced dopamine release in the medial prefrontal cortex of the rat: an in vivo microdialysis study.
Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT.
Central administration of methamphetamine synergizes with metabolic inhibition to deplete striatal monoamines.
Rapid and transient inhibition of mitochondrial function following methamphetamine or 3,4-methylenedioxymethamphetamine administration.
Alterations in respiratory behavior, brain neurochemistry and receptor density induced by pharmacologic suppression of sleep in the neonatal period.
Mazindol attenuates the 3,4-methylenedioxymethamphetamine-induced formation of hydroxyl radicals and long-term depletion of serotonin in the striatum.
Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine.
The role of dopamine D4 receptor in the induction of behavioral sensitization to amphetamine and accompanying biochemical and molecular adaptations.
Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra.
Effect of acute stress on hippocampal glutamate levels and spectrin proteolysis in young and aged rats.
Potentiation of 3,4-methylenedioxymethamphetamine-induced dopamine release and serotonin neurotoxicity by 5-HT2 receptor agonists.
Effect of scopolamine on the efflux of dopamine and its metabolites after clozapine, haloperidol or thioridazine.
Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations.
Differential effects of locally administered clozapine and haloperidol on dopamine efflux in the rat prefrontal cortex and caudate-putamen.
Effect of D-amphetamine on the extracellular concentrations of glutamate and dopamine in iprindole-treated rats.
Adrenalectomy attenuates stress-induced elevations in extracellular glutamate concentrations in the hippocampus.
A system for measuring electrophysiological multiple unit activity and extracellular dopamine concentration at single electrodes.
Extracellular glutamate levels increase with age in the lateral striatum: potential involvement of presynaptic D-2 receptors.
The effect of the atypical antipsychotic drug, amperozide, on carrier-mediated striatal dopamine release measured in vivo.
Methamphetamine neurotoxicity and striatal glutamate release: comparison to 3,4-methylenedioxymethamphetamine.
Selective subregional dopamine depletions in the rat caudate-putamen following nigrostriatal lesions.
A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis.
In vivo neurochemical and anatomical heterogeneity of the dopamine uptake system in the rat caudate putamen.
Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat.
An improved and rapid HPLC-EC method for the isocratic separation of amino acid neurotransmitters from brain tissue and microdialysis perfusates.
In vivo electrochemical determination of extracellular dopamine in the caudate of freely-moving rats after a low dose of ethanol.
Regional brain dopamine metabolism: a marker for the speed, direction, and posture of moving animals.
Asymmetric dopamine and serotonin metabolism in nigrostriatal and limbic structures of the trained circling rat.
Drug and food-deprivation modulation of activity in rats given chronic dietary lead: significance of type of activity measure.
Using profiles of saccharin and water drinking to detect and discriminate actions of drugs and toxicants.
Increased and decreased preference for saccharin immediately following injections of various agents.
A frequency analysis of behavior components of the serotonin syndrome produced by p-chloroamphetamine.
New York Academy of Sciences
Society for Neuroscience
Desc: Distinguished Lecturer
Org: Indiana University School of Medicine
Desc: Robert B. Forney Professor of Toxicology
Org: Society for Neuroimmune Pharmacology
Desc: Plenary Lecturer
Org: University of Toledo College of Medicine
Desc: Raymond and Beverly Sackler Distinguished Professor of Neurosciences
Org: Society for Neuroimmune Pharmacology
Desc: Plenary Lecturer
Org: International Conference and Exhibition on Addiction Research and Therapy
Desc: Plenary Lecturer
Org: Inaugural Reward and Deficiency Syndrome Summit (RDS Summit)
Desc: Plenary Lecturer