Andrea Bonetto

Andrea Bonetto, PhD

Assistant Professor of Surgery



Beginning with my graduate studies, my research has focused on the identification of the molecular factors that are responsible for muscle wasting, a condition frequently observed in both muscular dystrophies and cancer cachexia. Throughout my PhD training my research involved characterizing the IGF-1 and myostatin signaling pathways by taking advantage of both experimental and clinical studies. Understanding the role of the IL-6/gp130/STAT3 pathway in cachexia has been the subject of my postdoctoral training. The main purpose of my work was to validate a key role for STAT3 in causing muscle atrophy associated with the development of different kinds of cancer. As Assistant Professor in the Department of Surgery at Indiana University, I am currently developing new experimental models of cancer cachexia (such as colorectal and ovarian cancer) and investigating novel mediators of muscle wasting and bone loss in association with cancer and/or chemotherapy. I am also interested in understanding how the energy metabolism is affected in cachexia and how alterations of the muscle-bone crosstalk can be prevented by modulating the overall metabolism.    


(317) 278-0302 

General Surgery
R3 C522 SGEN
Indianapolis, IN


Alzheimers Disease
Translational Research

Titles & Appointments

  • Adjunct Assistant Professor of Otolaryngology-Head & Neck Surgery
  • Adjunct Assistant Professor of Anatomy and Cell Biology