Andrea Bonetto

Andrea Bonetto, PhD

Assistant Professor of Surgery

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Bio

Beginning with my graduate studies, my research has focused on the identification of the molecular factors that are responsible for muscle wasting, a condition frequently observed in both muscular dystrophies and cancer cachexia. Throughout my PhD training my research involved characterizing the IGF-1 and myostatin signaling pathways by taking advantage of both experimental and clinical studies. Understanding the role of the IL-6/gp130/STAT3 pathway in cachexia has been the subject of my postdoctoral training. The main purpose of my work was to validate a key role for STAT3 in causing muscle atrophy associated with the development of different kinds of cancer. As Assistant Professor in the Department of Surgery at Indiana University, I am currently developing new experimental models of cancer cachexia (such as colorectal and ovarian cancer) and investigating novel mediators of muscle wasting and bone loss in association with cancer and/or chemotherapy. I am also interested in understanding how the energy metabolism is affected in cachexia and how alterations of the muscle-bone crosstalk can be prevented by modulating the overall metabolism.    

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(317) 278-0302 


General Surgery
R3 C522 SGEN
Indianapolis, IN


  

Alzheimers Disease
Cancer
Musculoskeletal
Translational Research

Titles & Appointments

  • Adjunct Assistant Professor of Otolaryngology-Head & Neck Surgery
  • Adjunct Assistant Professor of Anatomy and Cell Biology