Andrea Bonetto, PhD
Assistant Professor of Surgery
Beginning with my graduate studies, my research has focused on the identification of the molecular factors that are responsible for muscle wasting, a condition frequently observed in both muscular dystrophies and cancer cachexia. Throughout my PhD training my research involved characterizing the IGF-1 and myostatin signaling pathways by taking advantage of both experimental and clinical studies. Understanding the role of the IL-6/gp130/STAT3 pathway in cachexia has been the subject of my postdoctoral training at the University of Miami Miller School of Medicine as well as Thomas Jefferson University in Philadelphia, PA. The main purpose of my work was to validate a ley role for STAT3 in causing muscle atrophy. As Assistant Professor in the Department of Surgery at Indiana University, I am currently developing new experimental models of cancer cachexia (colorectal, ovarian and pancreatic cancer) and investigating novel mediators of muscle wasting in association with chemotherapy.
R3 C522 SGEN
Titles & Appointments
- Adjunct Assistant Professor of Otolaryngology-Head & Neck Surgery
American Physiology Society
Society on Cachexia, Sarcopenia and Wasting Disorders