Zhiyong Tan, PhD
Assistant Research Professor of Pharmacology & Toxicology
Dr. Tan graduated from Shanghai Institute of Physiology where he began his research on ion channels using patch clamp. He continued his ion channel research as postdocs at Yale University (Mentor: Robert LaMotte) & at University of Iowa (Mentor: Francois Abboud). Dr. Tan joined IUSM in 2012 working with Dr. Theodore Cummins and was promoted to Assistant Research Professor in 2015. Dr. Tan has been independent Since Jul 2016.
Ion Channel and Membrane Excitability Mechanisms in Diseases
My research has been focused on the ion channel and membrane excitability mechanisms at peripheral system. The ion channels studied include voltage-gated sodium, potassium, and calcium channels and acid-sensitive sodium and potassium channels. The roles of relevant ion channels have been studied in pain sensation at dorsal root ganglion (DRG), chemo-sensitivity at arterial chemoreceptors, hormone secretion in adrenal gland, and peripheral sympathetic activity at sympathetic ganglion, respectively. Currently, we are studying peripheral ion channel mechanism and treatment in chronic pain conditions that are associated with chemotherapy drug-induced peripheral neuropathy (CIPN) and spinal cord injury (SCI).We are also collaborating with researchers interested in ion channels/membrane excitability of DRG and other cells.