Gustavo A. Arrizabalaga

Gustavo A. Arrizabalaga, PhD

Professor of Pharmacology & Toxicology

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Bio

Dr. Gustavo Arrizabalaga has been studying the cell biology of the pathogenic parasite Toxoplasma gondii for over fifteen years. He received his Ph.D. in Biology from MIT under the mentorship of Dr. Ruth Lehmann. His doctoral work focused on developmental biology and translational regulation using Drosophila as a model system. From 1999 to 2004 Dr. Arrizabalaga did a post-doctoral fellowship with Dr. John Boothroyd at Stanford University School of Medicine, where he began focusing on how Toxoplasma gondii exits its host cell. From 2004 to 2012 he was a faculty member at the University of Idaho where he established an independent research group. In 2012, he joined the Departments of Pharmacology and Toxicology and Microbiology and Immunology as an Associate Professor. He was promoted to full professor in 2017.

Key Publications

Roiko, M.S., LaFavers, K., Arrizabalaga, G., 2017 Toxoplasma gondii-positive human sera recognize intracellular tachyzoites and bradyzoites with diverse patterns of immunoreactivity, Int J. for Parasitology.

LaFavers, K.A, Márquez-Nogueras, K.M., Coppens, I., Moreno, SNJ, Arrizabalaga, G., 2017 A novel dense granule protein, GRA41, regulates timing of egress and calcium sensitivity in Toxoplasma gondii. Cell Microb, PMID: 28430089

Colinot, D.L., Garbuz, T., Bosland, M., Rice, S., Wang, L., Sullivan, W.J., 1Jerde, T. 1Arrizabalaga, G., 2017 Toxoplasma gondii: a novel inducer of chronic prostatic inflammation and proliferative inflammatory microglandular hyperplasia in a mouse model of prostatic inflammation. Prostate, PMID: 28497488. 1 Senior authors contributed equally

Padgett, L., 1Sullivan, W.J., 1Arrizabalaga, G., 2016, Targeting of tail-anchored membrane proteins to subcellular organelles in Toxoplasma gondii. Traffic. 2017 Mar;18(3):149-158. PMID:27991712 1 Senior authors contributed equally

Charvat, R. and Arrizabalaga, G., 2016. Oxidative stress generated during monensin treatment contributes to altered Toxoplasma gondii mitochondrial function. Nature Scientific Reports, Mar 15;6. PMID: 26976749

Gaji, R., Johnson, D., Wang, M., Hudmon, A., and Arrizabalaga, G., 2015. Phosphorylation of a Myosin motor by TgCDPK3 facilitates rapid initiation of motility during Toxoplasma gondii egress. PLoS Pathog. 1(11):e1005268. PMID: 26544049

Benmerzouga, I., Checkley, L., Ferdig, M., Arrizabalaga, G., Wek, R., and Sullivan, W., 2015. Guanabenz repurposed as an anti-parasitic with activity against acute and latent toxoplasmosis, Antimicrob Agents Chemother, 59(11):6939-45. PMID: 26303803

Treeck, M., Sanders, J., Gaji, R., LaFavers, K., Child, M., Arrizabalaga, G., Elias, J., Boothroyd, J., 2014. A novel role of Calcium-dependent Kinase 3 in regulating metabolism in Toxoplasma gondii in addition to ionophore induced egress. PLoS Pathogen, 10(6):e1004197. PMID: 24945436

Gaji, R., Checkley, L., Reese, M., Ferdig, M.T., and Arrizabalaga, G., 2014. Expression of the essential kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs. Antimicrob Agents Chemother, 58(5):2598-607. PMID: 24550330

Garrison, E., Treeck, M., Ehret, M., Garbuz, T., Oswald, B.P., Settles, M., Boothroyd, J., Arrizabalaga, G., 2012. A forward genetic screen reveals calcium-dependent kinase 3 is critical for calcium-induced egress in Toxoplasma. Plos Pathogen, 8(11). PMDI: 23209419

Lavine, M.D. and Arrizabalaga, G., 2012, Analysis of Monensin Sensitivity in Toxoplasma gondii reveals autophagy as a mechanism for drug induced death. Plos One, 7(7):e42107. PMID: 22848721

 

Francia, M.E., Wicher S., Pace D.A., Sullivan, J., Moreno, S.N.J., and Arrizabalaga, G., 2011. A Toxoplasma protein with homology to intracellular type Sodium Hydrogen Exchangers is required for osmotolerance and protein processing. Experimental Cell Research. 317(10):1384-96. PMID: 21501607

Lavine, M.D. and Arrizabalaga, G., 2011. The antibiotic monensin causes cell cycle disruption of Toxoplasma gondii, mediated through the DNA repair enzyme TgMSH-1. Antimicrob Agents Chemother, 55(2): 745-55. PMID: 21098240

Garrison, E. and Arrizabalaga, G., 2009. Disruption of a mitochondrial homolog of a MutS DNA Repair Enzyme confers drug resistance in the pathogenic parasite Toxoplasma gondii. Molecular Microbiology, 72(2):425-41. PMID 19291232

 

Arrizabalaga, G., Ruiz, F., Moreno, S. and Boothroyd J.C., 2004. Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation. Journal of Cell Biology: 165(5):653-62,. PMID: 15173192

 

Connect


garrizab@iu.edu 


(317) 278-6355 


PHARMACOLOGY & TOXICOLOGY
R2 E380 PHTX
Indianapolis, IN


  

Titles & Appointments

  • Professor of Microbiology & Immunology