Heather A. O'Leary, PhD
Assistant Professor of Medicine
980 West Walnut Street, R3-C321D (office), R3-330 (lab) HEMO
Indianapolis, IN 46202
Titles & Appointments
- Adjunct Assistant Professor of Cellular & Integrative Physiology
The objectives of our laboratory are to understand how hypoxia, hypoxia sensitive proteins, and components of the bone marrow microenvironment modify normal/malignant hematopoietic stem cell phenotype, signaling, function, and niche preference. Our overall goals are to better understand normal and malignant cell dynamics and use this information to discover targeted pathways to diminish leukemic cell growth/survival, while enhancing normal hematopoietic stem cell engraftment.
The importance of hypoxia and extra physiologic oxygen shock/stress for collection and processing of stem and progenitor cells to understand true physiology/pathology of these cells ex vivo.
Implications of DPP4 modification of proteins that regulate stem/progenitor and more mature cell types.
Contribution of electromechanical coupling between Kv and Ca v1.2 channels to coronary dysfunction in obesity.
Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis.
American Association for Cancer Research
International Society for Experimental Hematology
International Society for Stem Cell Research (ISSCR)