Heather A. O'Leary, PhD
Assistant Professor of Medicine
Titles & Appointments
- Adjunct Assistant Professor of Cellular & Integrative Physiology
The objectives of our laboratory are to understand the mechanisms by which components of the bone marrow microenvironment modify normal/malignant hematopoietic stem cell phenotype, signaling, function, and niche preference. More specifically, we are interested in low oxygen tension in the niche and the true biology of hematopoietic cells in their native setting. Our overall goals are to better understand normal and malignant cell dynamics and use this information to discover targeted pathways to diminish leukemic cell growth/survival, while enhancing normal hematopoietic stem cell engraftment, bridging the disconnect between basic biology, pre-clinical models and clinical success.
High-dose sitagliptin for systemic inhibition of dipeptidylpeptidase-4 to enhance engraftment of single cord umbilical cord blood transplantation.
DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms.
The importance of hypoxia and extra physiologic oxygen shock/stress for collection and processing of stem and progenitor cells to understand true physiology/pathology of these cells ex vivo.
Implications of DPP4 modification of proteins that regulate stem/progenitor and more mature cell types.
Contribution of electromechanical coupling between Kv and Ca v1.2 channels to coronary dysfunction in obesity.
Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis.
VE-cadherin and PECAM-1 enhance ALL migration across brain microvascular endothelial cell monolayers.
VE-cadherin Regulates Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Sensitivity to Apoptosis.
Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells.
American Society of Hematology
International Society for Experimental Hematology
International Society for Stem Cell Research (ISSCR)
Desc: Translational Research Training in Hematology (TRTH, 20 selected from US & Europe)