Timothy W. Corson, PhD
Associate Professor of Ophthalmology
Dr. Corson is the Merrill Grayson Senior Chair in Ophthalmology, Showalter Scholar and Director of Basic and Translational Research in the Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, with appointments in the Department of Biochemistry and Molecular Biology and the Department of Pharmacology and Toxicology. He is also a member of the IU Melvin and Bren Simon Cancer Center, Stark Neurosciences Research Institute, and Center for Diabetes and Metabolic Diseases.
Originally Australian, he completed BSc, MSc and PhD degrees at the University of Toronto, Canada, where his dissertation work with advisor Dr. Brenda L. Gallie included the discovery of KIF14 as an oncogene in retinoblastoma and other cancers. Subsequently, he moved into chemical biology research as the Canadian Institutes of Health Research Jean-François St-Denis Fellow in Cancer Research at Yale University.
Working with Dr. Craig M. Crews, he explored the mechanism of the potent natural product triptolide, developed a novel approach to target HIV, and worked on techniques for targeted protein degradation. Since starting his own laboratory in 2010, he has brought chemical biology approaches to bear on problems in ophthalmology, pursuing KIF14 as a therapeutic target in retinoblastoma and beyond and undertaking mechanistic and therapeutic studies of antiangiogenic natural products.
He has identified two novel protein targets for blocking neovascularization in eye diseases like wet age-related macular degeneration, and has discovered novel lead therapeutic compounds covered by multiple patent applications. He has authored over 50 publications. Dr. Corson’s lab is funded by the Retina Research Foundation, the Indiana CTSI, and an NIH/NEI R01, and has been supported by grants from the International Retinal Research Foundation, the Showalter Research Trust, the BrightFocus Foundation, and St. Baldrick’s Foundation.
Other previous honors include the Alcon Research Institute Young Investigator Award, a KL2 career development award from NIH/NCATS, and the Watanabe Translational Scholar Award from the Indiana CTSI.
Titles & Appointments
- Associate Professor of Biochemistry & Molecular Biology
- Adjunct Associate Professor of Pharmacology & Toxicology
- Director of Basic and Translational Research, Glick Eye Institute
- The Merrill Grayson Senior Chair in Ophthalmology
The Corson lab seeks to apply the tools and techniques of chemical biology to problems in eye disease. Specifically, we are interested in understanding the biology of, and developing potential therapies for, the pediatric ocular cancer retinoblastoma.
For more details, please visit the lab's website at:
Molecular Cancer GeneticsCourse Number: G724
Fundamentals of NeuroscienceCourse Number: G780
NeuroanatomyCourse Number: N715
Association for Research in Vision and Ophthalmology
International Chemical Biology Society
International Society for Eye Research
International Society of Ocular Oncology
Desc: Watanabe Translational Scholar
Org: Indiana University School of Medicine
Desc: Showalter Scholar
Org: Canadian Institutes of Health Research
Desc: Jean-Francois St-Denis Fellowship in Cancer Research