Lilian I. Plotkin, PhD
Associate Professor of Anatomy & Cell Biology
Dr. Plotkin is an Associate Professor at the Department of Anatomy and Cell Biology, Indiana University School of Medicine in Indianapolis, IN, U.S.A. She obtained her degree in Immunology at the Universidad Nacional de Buenos Aires, Argentina. Dr. Plotkin performed postdoctoral training from 1998 to 2002 and was a Faculty member from 2002 to 2008 at the Endocrinology Division and the Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences in the U.S.A. Dr. Plotkin’s research focuses on the role of connexin 43 and connexin 37 as a regulators of intracellular signaling activated by pharmacotherapeutic, hormonal and mechanical stimuli in bone. Her work has been published in Journal of Clinical Investigation, Cell, Science, Journal of Biological Chemistry, American Journal of Physiology, Journal of Bone and Mineral Research, Bone and Aging Cell. Dr. Plotkin’s research has been supported by local grants, and the National Osteoporosis Foundation and the National Institutes of Health.
The Plotkin laboratory focuses on the role of connexins on bone cell function and on skeletal homeostasis. Through interactions with several primary faculty members, Dr. Plotkin has developed a program to evaluate the consequences of Cx43 and Cx37 deletion from the cell to the whole skeleton; and their role on the effect of hormones, mechanical signals and pharmaco-therapeutic agents. Trainees in the Plotkin lab will participate in in vitro studies, including analysis of gene expression, kinase activity, cell-to-cell communication, and cell viability and proliferation. In vivo studies include evaluation of bone mass and strength, cell number and activity; as well as prevalence of apoptosis. Students will be trained on a variety of techniques, including cellular (e.g., tissue culture, primary cell isolation from mice), molecular (e.g., RNA and protein isolation, western blotting, ELISA), radiological (e.g., DEXA, microCT), and histological (e.g., tissue procurement and embedding, thick and thin sectioning, staining, immunohistochemistry, dynamic and static histomorphometry).