Samy Meroueh, PhD
Associate Professor of Biochemistry & Molecular Biology
I received a Ph.D. from the Department of Chemistry at Wayne State University in the laboratory of William Hase. There, I explored and developed methods to model intermolecular forces that drive molecular recognition and ensuing chemical reactions. As a postdoc, I joined the bioorganic laboratory of Dr. Shahriar Mobashery first at Wayne State University and then at the University of Notre Dame. I worked on understanding the mechanism by which β-lactamases hydrolyze β-lactam antibiotics. I was also involved in the development of mechanism-based small-molecule inhibitors of matrix metalloproteinases (MMP2), cathepsin B, and β-lactamases. In my lab at Indiana University, we are interested in developing chemical tools to modulate protein-protein interactions, particularly those that drive cancer metastasis or prevent repair following spinal cord and traumatic brain injury. We are interested in both covalent and non-covalent compounds that either inhibit or activate protein-protein interactions. We employ structure-based computational approaches to design small molecules that we characterize through biochemical and biophysical studies for binding and inhibition. We also explore these compounds in cell culture and animal models. In addition to my past and existing funding from the National Institutes of Health, I am a recipient of a Research Scholar Award from the American Cancer Society. I am also a member of the Department of Veterans Affairs. In addition to my appointment in Biochemistry, I am a member of the Indiana University Center for Computational Biology and Bioinformatics, the Stark Neurosciences Institute, and the Simon Cancer Center.
In my laboratory at the Indiana University School of Medicine, we develop chemical probes to explore protein-protein interactions in cancer and neurodegenerative diseases. We design, synthesize, and develop biochemical and biophysical assays to identify promising compounds that we use in cell culture and animal models. We are interested in individual protein-protein interactions such as those of the urokinase receptor, Ral GTPase, and TEAD transcription factors. We are exploring the role of uPAR in breast cancer bone metastasis, Ral GTPases in lung cancer, and TEAD transcription factors in breast and glioblastoma. We are also interested in mapping druggable sites across the human protein-protein interaction network, docking chemical libraries to these pockets, and integrating this interactome with genomic and proteomic data to uncover new small molecules to suppress the complex phenotypes associated with cancer, particularly glioblastoma multiforme.