Yan Xu, PhD
Hulman-George Family Professor of Gynecologic Cancer
My main research interests deal with understanding at the molecular level the mechanism of development and progress of the molecular aspects of ovarian, prostate, colon and other cancers. In particular, we are interested in tumor microenvironment and metastasis, as well as anoikis-resistance. These include developing effective diagnostic and prognostic biomarkers for these diseases, studying signaling mechanistic studies, identifying novel therapeutic targets and methods to treat them. Several mouse models have been established or under development to address mechanisms underlying tumor initiation, progression, and metastasis.
Our current research focuses: 1) investigate the role and signaling mechanisms of LPA and their receptors in ovarian and other cancers using both in vitro and in vivo studies; 2) study cancer stem cells; and 3) identify novel and efficacious ovarian cancer treatment targets.
Tumor metastasis and microenvironment
Mouse models of ovarian cancer
Anoikis-resistance in ovarian cancer
Role of lysophospholipids in ovarian cancer
Development of diagnostic and prognostic markers for ovarian and other cancers
G protein coupled receptors for bioactive lysophospholipids and their signaling pathways
Qipeng Fan (Research Associate)
Obstetrics And Gynecology
R4 037 OBGY
Titles & Appointments
- Professor of Obstetrics & Gynecology
- Professor of Biochemistry & Molecular Biology
Molecular mechanisms of cancer development
Role and signaling mechanisms of bioactive lysophospholipids and their receptors
Development of ovarian cancer models
Identification of novel and efficacious ovarian cancer treatment targets
Cancer stem cells
Li Zhang, professor, Toronto General Research Institute, University of Toronto.
Liang Cheng, Professor of Pathology and Urology, Indiana University School of Medicine (IUSM). Randy R. Brutkiewicz, Ph.D. Professor of Microbiology and Immunology, IUSM.
Kao, Chinghai, Associate Professor, Thomson Scholar of Prostate Cancer Research, IUSM
Piccirillo, Ciriaco A., Associate professor, Department of Microbiology and Immunology, McGill University, Faculty of Medicine Center for the Study of Host resistance, MUHC.
Jinwu Xie, Jonathan and Jennifer Simmons Professor of Pediatrics, Department of Pediatrics, IUSM.
Zhong-yin Zhang, Robert A. Harris Professor and Chairman, Department of Biochemistry and Molecular Biology, IUSM.
Ken Nephew, Professor, Indiana University School of Medicine.
Mircea Ivan, Associate Professor, Department of Medicine, Division of Hematology/Oncology, IU School of Medicine.