Karl R. Koehler, PhD
Assistant Professor of Otolaryngology-Head & Neck Surgery
Laboratory: 3D Stem Cell Biology Research Group
Karl Koehler, PhD, was appointed Assistant Professor of Otolaryngology-Head and Neck Surgery in July 2015. He joined IU School of Medicine in 2008 as a Medical Neuroscience graduate student and later, as a postdoctoral fellow in 2014. Dr. Koehler began his career in biomedical research studying how embryonic and induced pluripotent stem cells could be used to produce neurons to treat hearing loss patients. His early work led to the invention of a new culture system for growing mini inner ear organs, known as organoids, from stem cells. His research now focuses on using the organoid culture system as a platform to develop regenerative therapies for the inner ear and various craniofacial tissues.
During his training, Dr. Koehler was the recipient of the Paul and Carole Stark Neuroscience Research Scholarship, the Larry Kays Scholarship, and the Linda and Jack Gill Graduate Student Award for outstanding achievements in research. His work is funded by grants from the National Institutes of Health and the Indiana Clinical and Translational Sciences Institute.
Visit koehlerlab.iu.edu for current research updates in the Koehler Lab, a part of the Indiana University School of Medicine 3D Stem Cell Biology Research Group.
Otolaryngology & H/N Surgery
Walther Hall (R3) C432B 980 W. Walnut Street
Indianapolis, IN 46202
Titles & Appointments
- Philip F. Holton Scholar of Otology
- Adjunct Assistant Professor in Anatomy & Cell Biology
Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells.
Directed Differentiation of Mouse Embryonic Stem Cells Into Inner Ear Sensory Epithelia in 3D Culture.
Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells.
Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP.
Class I(A) PI3Kinase regulatory subunit, p85a, mediates mast cell development through regulation of growth and survival related genes.
In-vivo assessment of migration and engraftment of stem cells in the cochlea using a high-resolution microscopic-endoscope.
Association for Research in Otolaryngology (ARO)
International Society for Stem Cell Research (ISSCR)