14076-Park, Su-Jung
Faculty

Su-Jung Park, PhD, MS

Adjunct Assistant Research Professor of Pediatrics

Address
1044 W Walnut street, R4 414


Indianapolis, IN 46202

Bio

Su-Jung Park, PhD, is an Assistant Research Professor of Pediatrics at Indiana University School of Medicine. She conducts her research within the Herman B Wells Center for Pediatric Research.

Dr. Park is a graduate of the University of InJe. She received her Masters in Science from the University of InJe and doctorate in Cell Biology and Biochemistry at the University of InJe. She holds membership in the American Association for Cancer Research.

Titles & Appointments

  • Adjunct Assistant Research Professor of Pediatrics
  • Education
    1996 PhD Inje University
    1991 MS Inje University
    1988 BS Inje University
  • Research

    As a member of the Clapp laboratory, Dr. Park studies the unknown the ubiquitin-proteasome pathway (UPP) of NF1 tumor suppressor protein.

    Neurofibromatosis type 1 (NF1) is the most common genetic disease in humans with a predisposition to cancer. NF1 is caused by mutations of NF1 tumor suppressor gene that functions as GAP for Ras. The molecular mechanism of NF1 haploinsufficiency has unknown. Yet, the primary mechanism of haploinsufficiency is due to insufficient protein level.

    Neurofibromin expression is not only diminished by genetic loss and epigenetic lesion but also the protein itself is a target for accelerated degradation. In light of the NF1 haploinsufficient degradation by Ubiquitin-Proteasome Pathway (UPP) is clinically importance. However, little is known about the molecular mechanism for degradation of neurofibromin by Ubiquitin-Proteasome Pathway.

    The goal of study is to contribute to the development of new therapeutic approaches to treat NF1 syndrome where neurofibromin is chronically destabilized.

  • Professional Organizations
    American Association for Cancer Research

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