Karen E. Pollok

Karen E. Pollok, PhD

Associate Professor of Pediatrics


Dr. Pollok is an Associate Professor of Pediatrics with a secondary appointment in the Department of Pharmacology and Toxicology. She serves as Director of the In Vivo Therapeutics and Angio Biocore Shared Resource Facilities for the Indiana University Simon Cancer Center. She also serves as the Basic Science Leader of the Brain Tumor Working Group and co-Director of the Signature Center for Brain and Neurological Tumors.

Key Publications


  1. S. Cai, H. Wang, A.R. Baluyut,  A. Ernstberger, B. Juliar, A.L. Sinn, L.D. Mayo, W. S. Goebel, and K.E. Pollok. Humanized bone-marrow xenograft model as a pre-clinical tool to assess therapy-mediated hematotoxicity. 2011. Clinical Cancer Research. 8:2195-2206. PMCID: PMC3078977.

  2. H. Wang, S. Cai, A. Ernstberger, B.J. Bailey, M.Z. Wang, W. Cai, W.S. Goebel, M.B. Czader, C. Crean, A. Suvannasankhah, I. Shokolenkoc, G.L. Wilson, A.R. Baluyut, L.D. Mayo, and K.E. Pollok. 2013. Temozolomide-mediated DNA methylation in human myeloid precursor cells: differential involvement of intrinsic and extrinsic apoptotic pathways. 2013. Clinical Cancer Research. 19(10): 2699-2709. PMCID: PMC3711223

  3. E. Tonsing-Carter, A.L. Sinn, J. Silver, K.M. Peterson, B.J. Bailey, C.M. Eischen, H. Wang, H.S. Shannon, J. Ding, S. Cai, P.R. Territo, G.E. Sandusky, L.D. Mayo, J. Li, C.B. Marchal, H. Hanenberg, and K.E. Pollok. 2015. Potentiation of carboplatin-mediated DNA damage by the MDM2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model. Mol Cancer Ther, 14(12):2850-63. PMCID: PMC4674357 Featured Highlight Article.

  4. H. Wang, S. Cai, B.J. Bailey, M.R. Saadatzadeh, E. Tonsing-Carter, J. Ding, T.M. Georgiadis, T.Z. Gunter, E.C. Long, R.E. Minto, K.R. Gordon, S.E. Sen, W. Cai, J.A. Eitel, D.L. Waning, L.R. Bringman, C.D. Wells, M.E. Murray, J. Sarkaria, L.M. Gelbert, D.R. Jones, A. Cohen-Gadol, L.D. Mayo, H.E. Shannon, and K.E. Pollok. 2017. Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an Mdm2 Antagonist. J Neurosurgery. 126(2):446-459. doi: 10.3171/2016.1.JNS152513. Epub 2016 May 13; PMID: 27177180.

  5. J. Carter, L. Cheng, J. Zucker, M. Marshall, K.E. Pollok, M. Murray, L. Li, and J. Renbarger. 2017. Use of Precision Medicine Molecular Profiling of Baseline Tumor Specimen May Not Benefit Outcomes in Children with Relapsed, Refractory, or Rare Pediatric Sarcomas. Clin Pharmacol Ther 2017 Mar;101(3):328-330.  PMID:  28001289.

  6. K. Bijangi-Vishehsaraei, M. Reza Saadatzadeh, H. Wang, A. Nguyen, M. M. Kamocka, W. Cai, A.A. Cohen-Gadol, S. L. Halum, J. N. Sarkaria, K. E. Pollok*, and A. R. Safa. (*co-corresponding authors). 2016. Sulforaphane suppresses growth of glioblastoma (GBM) cells, GBM stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways.  2017. Journal of Neurosurgery, Epub 2017 Jan 6; http://thejns.org/doi/10.3171/2016.8.JNS161197.








Complete List of Published Work in MyBibliography:











(317) 274-8891 

Ped-Heme/Onc Basic Research
R4 302 PHMB
Indianapolis, IN


Personalized Medicine
Translational Research

Titles & Appointments

  • Adjunct Associate Professor of Pharmacology & Toxicology
  • Adjunct Associate Professor of Medical & Molecular Genetics