Cong Yan

Cong Yan, PhD

Professor of Pathology & Laboratory Medicine

Bio

 

 

1982            CUSBEA (China-United States Biochemistry Examination and Application) Program Graduate Student Scholarship

1987-90        Postdoctoral Fellow, Laboratory of Cell Physiology and Virology, The Rockefeller University, New York, NY

1990-92    Research Associate, Laboratory of Cell Physiology and Virology, The Rockefeller University, New York, NY

1992-94      Assistant Professor, Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH

1994-2005  Instructor-Associate Professor, Division of Pulmonary Biology, Children’s Hospital Medical Center, Cincinnati, OH

2002-          Visiting Professor, Tongji Medical College of Huazhong University of Science and Technology, China

2003-         Member of Advisory Board, Chongqing Children’s Research Center, Chongqing, China.

2004-         Guest Professor, Chongqing University of Medical Sciences, Chongqing, China.

2005-         Professor, the Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN

2005-         Member, the Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN

2006-          Member, Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, IN

 

Other experience and professional membership

 

2003            Ad hoc Reviewer, Lung Biology and Pathology Study Section, NIH.

2006            Ad hoc Reviewer, Lung Injury, Repair, and Remodeling Study Section, NIH. 

2007-09      Member of Allergy, Immunology and Inflammation Program Committee, American Thoracic Society 

2009                Reviewer, American Heart Association, Lung, Respiration and Resuscitation Review Committee 

2009           Reviewer, Emphasis Panel/Scientific Review Group ZRG1 Biology of Development and Aging, NIH RC-1 Challenge Grant. 

2010-               Reviewer, American Heart Association, Lung CT Review Committee 

2010-         Founding member of the honorary editorial board, Journal Current Biomarker Findings.   

2010-11       Reviewer, the James & Esther King Biomedical Research Program and the Bankhead-Coley Cancer Research Program, the Florida Department of Health (managed by Lytmos Group). 

2011           Reviewer, American Heart Association, Lung CT Review Committee 

2012           Reviewer, Cancer Immunopathology and Immunotherapy Study Section (CII), Oncology 1-Translational Clinical Integrated Review Group, NIH 

2012           Reviewer, Research Answers to NCI’s Provocative Questions, NCI 

2012            Reviewer, American Heart Association, Lung 2 Peer Review Study Group, September 

2013           Reviewer, Cancer Immunopathology and Immunotherapy Study Section (CII), Oncology 1-Translational Clinical Integrated Review Group, NIH, June 12 

2014           Reviewer, 2014 State Natural Science Award of the People's Republic of China 

2014           Reviewer, Belgian Foundation against Cancer (Asbestos Fundamental Research Grants) 

2014           Reviewer, NCI PAR-14-085: Metabolic Reprogramming in Immunotherapy  

2015           Reviewer, 2015 State Natural Science Award of the People's Republic of China (the highest national achievement award in China) 

2016           Reviewer, Belgian Foundation against Cancer (Asbestos Fundamental Research Grants) 

2014-20      Regular member, Cancer Immunopathology and Immunotherapy Study     Section (CII), Oncology 1-Translational Clinical Integrated Review Group,  NIH.

 

 1985-87       Member, American Chemical Society 

1988-92       Member, International Society for Interferon Research 

1993-05       Member, American Society for Biochemistry and Molecular Biology 

1993-05       Member, the American Society for Cell Biology 

2006-10       Member, American Thoracic Society

2010-              Member, American Association for Cancer Research

 

 

Key Publications

Publications in last three years.

(1) Cong Yan and Hong Du: Lysosomal acid lipase is critical for myeloid-derived suppressive cell differentiation, development, and homeostasis (2014). World J Immunol; 4(2): 42-51.

 

(2) Xinchun Ding, Hong Du, Mervin C. Yoder, and Cong Yan (corresponding author): Critical Role of the mTOR Pathway in Development and Function of Myeloid-derived Suppressor Cells in lal-/- Mice (2014). The American Journal of Pathology,184(2):397-408. PMID: 24287405.

 

(3) Ting Zhao, Xinchun Ding, Hong Du, and Cong Yan (co-corresponding author): Myeloid-derived Suppressor Cells Are Involved in Lysosomal Acid Lipase Deficiency-Induced Endothelial Cell Dysfunction (2014).  The Journal of Immunology, 193(4):1942-53.

 

(4) Stanley Ching-Cheng Huang, Bart Everts, Yulia Ivanova, David O’Sullivan, Marcia Nascimento, Amber M. Smith, Wandy Beatty, Lastisha Love-Gregory, Wing Y. Lam, Christina M. O’Neill, Cong Yan, Hong Du, Nada A. Abumrad, Joseph F. Urban, Jr., Maxim N. Artyomov, Erika L. Pearce, and Edward J. Pearce: Cell-intrinsic lysosomal lipolysis is essential for macrophage alternative activation (2014). Nature Immunology, 15(9):846-55. PMID: 25086775.

 

(5) Xinchun Ding, Wu, L., Cong Yan, (co-corresponding author), and Du, H. (2015). Establishment of lal-/- Myeloid Lineage Cell Line That Resembles Myeloid-Derived Suppressive Cells. PLoS One 10, e0121001. PMID: 25807535.

 

(6) Cong Yan, Ting Zhao, Hong Du: Lysosomal Acid Lipase in Cancer – Editorial (2015). Oncoscience, 2(9):727-28.

 

(7) Ting Zhao, Hong Du, Xinchun Ding, Katlin Walls, and Cong Yan (corresponding author): Activation of mTOR Pathway in Myeloid-derived Suppressor Cells Stimulates Cancer Cell Proliferation and Metastasis in lal-/- Mice (2015). Oncogene, 2015 Apr 9;34 (15):1938-48. Epub 2014 Jun 2. PMID: 24882582.  Highlighted by Immune Regulation News 6.20.

 

(8) Hong Du, Ting Zhao, Xinchun Ding, Cong Yan: Hepatocyte-specific expression of human lysosome acid lipase corrects liver inflammation and tumor metastasis in lal-/- mice (2015). The American Journal of Pathology, 185(9):2379-89. PMID 26212911.

 

(9) Ting Zhao, Hong Du, Janice Blum, Cong Yan: Critical Role of PPARγ in Myeloid-Derived Suppressor Cell-Stimulated Cancer Cell Proliferation and Metastasis (2016). Oncotarget, 12;7(2):1529-43.

 

(10) Vinit Kumar, Pingyan Cheng, Thomas Condamine, Sridevi Mony, Lucia R. Languino, Judith C. McCaffrey, Neil Hockstein, Michael Guarino, Gregory Masters, Emily Penman, Fred Denstman, George Xu, Dario C. Altieri, Hong Du, Cong Yan, Dmitry I. Gabrilovich: CD45 phosphatase regulates the fate of myeloid cells in tumor microenvironment by inhibiting STAT3 activity (2016). Immunity, 44, 303–315.

 

(11) Ting Zhao, Xinchun Ding, Hong Du, Cong Yan: Lung Epithelial Cell-Specific Expression of Human Lysosomal Acid Lipase Corrects Lung Inflammation and Tumor Metastasis in lal−/− Mice. The American Journal of Pathology, 186(8):2183-92.

 

(12) Ting Zhao, Hong Du, Cong Yan: Lysosomal Acid Lipase in Mesenchymal Stem Cell Stimulation of Tumor Growth and Metastasis (2016). Oncotarget, 20;7(38):61121-61135.

 

(13) Lukas Grumet, Thomas O. Eichmann, Ulrike Taschler, Kathrin A. Zierler, Christina Leopold, TarekMoustafa, Branislav Radovic, Matthias Romauch, Cong Yan, Hong Du, Guenter Haemmerle, Rudolf Zechner, Peter Fickert, Dagmar Kratky, Robert Zimmermann, and Achim Lass: Lysosomal acid lipase hydrolyzes retinyl ester and affects retinoid turnover (2016). Journal of Biological Chemistry, 19;291(34):17977-87.

 

(14) Xinchun Ding, Wenjing Zhang, Ting Zhao, Cong Yan, Hong Du: Rab7 GTPase controls lipid metabolic signaling in myeloid-derived suppressor cells (2017). Oncotarget, 8(18): 30123–30137.

 

(15) Hong Du, Xinchun Ding, and Cong Yan: Metabolic reprogramming of myeloid-derived suppressive cells (2017). Oncoscience. 4(3-4): 29–30.

 

(16) Maidina Tuohetahuntila, Martijn R. Molenaar, Bart Spee, Jos F. Brouwers, Richard Wubbolts, Martin Houweling, Cong Yan, Hong Du, Brian C VanderVen, Arie B. Vaandrager and J. Bernd Helms: Lysosome-mediated Degradation of a Distinct Pool of Lipid Droplets during Hepatic Stellate Cell Activation (2017). Journal of Biological Chemistry. 2017 Jun 14. pii: jbc.M117.778472.

 

(17) Ting Zhao, Cong Yan, Hong Du: Endothelial Rab7 GTPase in Tumor Growth and Metastasis (2017). Journal of Biological Chemistry, in revision.

 

Connect


coyan@iupui.edu 


317-278-6005 


PATHOLOGY AND LABORATORY MED
Indiana University School of Medicine, Dept of Pathology and Laboratory Medicine 975 W Walnut St, Room IB 424G
Indianapolis, IN 46202