Jill C. Fehrenbacher

Jill C. Fehrenbacher, PhD

Associate Professor of Pharmacology & Toxicology


Dr. Fehrenbacher received a B.S. from the University of Southern Indiana in 1999 and a  Ph.D. from Indiana University in 2005. She completed her postdoctoral fellowship in the Department of Endodontics at the University of Texas Health Science Center in San Antonio. In 2010, she joined Indiana University as an Assistant Professor with a primary appointment in the Department of Pharmacology and Toxicology and as a member of the Stark Neurosciences Research Institute.



2009: Maria Yeung Dental Research Award, University of Texas Health Science Center at San Antonio, Texas

2008: Dental Science Symposiumn, 1st Place, Postdoctoral Division, University of Texas Health Science Center at San Antonio, Texas

2008: Center for Biomedical Neuroscience Annual Retreat, First Place Postdoctoral Division, University of Texas Health Science Center at San Antonio, Texas

2004 - 2005: K.K. Chen Fellowship, Indiana University School of Medicine, Indianapolis, Indiana

2002: Graduate Student Educational Enhancement Award, Indiana University Graduate School, Indianapolis, Indiana

1995 - 1999: Scholastic Excellence Award, University of Southern Indiana, Evansville, Indiana

1998 - 1999: Bertram Bennett Athletic and Academic Excellence Scholarship, University of Southern Indiana, Evansville, Indiana


Key Publications

Darby LM, Meng H, Fehrenbacher JC (2017). Paclitaxel inhibits the activity and membrane localization of PKCα and PKCβI/II to elicit a decrease in stimulated calcitonin gene-related peptide release from cultured sensory neurons, Molecular and Cellular Neuroscience, 82: 105.

Shah F, Logsdon D, Messman R, Fehrenbacher JC, Fishel M, Kelley M (2017). Exploiting the APE1-Ref-1 node in cancer signaling and other diseases: from bench to clinic. Nature Partner Journals Precision Oncology, 1: Article #19.

Fehrenbacher JC and Richardson JD (2017).  NSAIDs and Acetaminophen. Brody's Human Pharmacology: Mechanism-Based Therapeutics, 6th edition, in press.

Kelley M, Fehrenbacher JC (2017). Challenges and opportunities identifying therapeutic targets for chemotherapy-induced peripheral neuropathy resulting from oxidative DNA damage. Neural Regeneration Research, 12:72.

Malty RH, Hudmon A, Fehrenbacher JC, Vasko MR. (2016) Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A. J Neuroinflammation 11:181.

Pittman SP, Gracias N, Fehrenbacher JC. (2016) Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons. Experimental Neurology, 279:104-115.

Duarte DB, Vasko MR, Fehrenbacher JC (2016). Models of Inflammation: Carrageenan Air Pouch. Current Protocols in Pharmacology, 72:5.6.1-9

Fehrenbacher JC, Bingener J, Aho JM, Wasky PR, Locke EE, Schwesinger WH, Van Sickle KR, Hargreaves KM (2015). Men with acute cholecystitis have higher tissue-based cytokine levels than women: a cross-sectional study. Chirurgia, 28:49-53.

Fehrenbacher JC (2015). Chemotherapy-induced peripheral neuropathy. Prog Mol Biol Tranl Sci: 131:471.

Chen X, Sun W, Glanaris NG, Riley AM, Cummins TR, Fehrenbacher JC, Obukhov AG (2014). Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel. J Biol Chem: 289: 9600.

Pittman SP, Gracias N, Vasko MR, Fehrenbacher JC (2014). Paclitaxel alters the evoked release of calcitonin gene-related peptide from rat sensory neurons in culture. Experimental Neurology: 253: 146.

Fehrenbacher JC, Vasko MR, Duarte DB (2012). Models of Inflammation: Carrageenan- or Complete Freund’s Adjuvant-Induced Edema and Hypersensitivity in the Rat. Current Protocols in Pharmacology, 5: Unit 5.4.

Duarte DB, Vasko MR, Fehrenbacher JC (2012). Models of Inflammation: Carrageenan Air Pouch. Current Protocols in Pharmacology, 5: Unit 5.6.


Brittain JM, Duarte DB, Wilson SM, Wang Y, Zhu W, Ballard C, Khanna M, Brustovetsky T, Schmutzler BS, Xiong W, Ripsch MS, Ashpole NM, Hudmon A, Meroueh SO, Hingtgen CM, Brustovesky N, Jim X, Vasko MR, Fehrenbacher JC, Hurley JH, White FA, Khanna R. (2011) Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex. Nature Medicine; 17:822.


Park KA, Fehrenbacher JC, Thompson EL, Guo CL, Hingtgen CM, Vasko MR. (2010) Nerve Growth Factor Augments Expression of Calcitonin Gene-Related Peptide in Sensory Neurons through activation of the Ras Signaling Cascade. Neuroscience; 171:910.


Fehrenbacher JC, Sun XX, Locke EE, Henry M, Hargreaves KM. (2009) Capsaicin-evoked iCGRP release from human dental pulp: a model system for the study of peripheral neuropeptide secretion in normal healthy tissue. Pain, 144:253-61.


Fehrenbacher JC, LoVerme J, Clarke W, Hargreaves KM, Piomelli D, Taylor BK. (2009) Rapid Pain Modulation with Nuclear Receptor Ligands. Brain Res Rev, 60:114-24.


Jeske NA, Diogenes A, Ruparel NB, Fehrenbacher JC, Henry M, Akopian AN, Hargreaves KM. (2008) A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1. Pain, 138: 604-16.


Zhang Y, Fehrenbacher JC, Vasko MR, Nicol GD. (2006) Sphingosine-1-phosphate via activation of a G protein-coupled receptor(s) enhances the excitability of rat sensory neurons. J Neurophys, 96: 1042-52.


Patwardhan AM, Diogenes A, Akopian AN, Berg KA, Clarke WP, Fehrenbacher JC, Hargreaves KM. (2006). PAR-2 agonists activate trigeminal nociceptors and induce functional competence in the Delta opioid receptor. Pain, 125: 114-24.


Fehrenbacher JC, Burkey TH, Nicol GD and Vasko MR. (2005). Tumor necrosis factor alpha and interleukin-1beta stimulate the expression of cyclooxygenase II but do not alter prostaglandin E2 receptor mRNA levels in cultured dorsal root ganglia cells. Pain, 113: 113-22.


Fehrenbacher JC, Taylor CP, Vasko MR. (2003). Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C.  Pain, 105: 133-41.


(317) 274-8360 

Pharmacology & Toxicology
Indianapolis, IN