Sara K. Quinney, PhD
Associate Professor of Obstetrics & Gynecology
Dr. Sara Quinney received a PharmD (2000) and a PhD in Clinical Pharmacy (2004) from Purdue University. She then completed postdoctoral fellowships at Indiana University School of Medicine (IUSM) in Clinical Pharmacology under the mentorship of Dr. Stephen Hall and in Biostatistics and Bioinformatics under Dr. Lang Li. Dr. Quinney is currently an Assistant Professor in the Department of Obstetrics and Gynecology, where she is a member of PREGMED, the Indiana University Signature Center for Pharmacogenetics and Therapeutics Research in Maternal and Child Health. She is also a member of the Institute of Personalized Medicine and the Center for Computational Biology and Bioinformatics at IUSM and the Associate Director of the Indiana CTSI’s Disease and Therapeutic Response Modeling Program. Dr. Quinney’s work utilizes in vitro bench-based wet lab studies, in vivo clinical studies, and in silico pharmacokinetic models to better understand factors influencing drug pharmacokinetics and response. Her work focuses largely on the individualization of drug therapy in special populations, and especially in understanding of changes in drug metabolism and pharmacokinetics in pregnancy. She is involved in a number of studies examining drugs such as methadone, betamethasone, and misoprostol in pregnant women. Dr. Quinney has developed physiologically based pharmacokinetic models to describe changes in drug metabolism in pregnancy, and is investigating the role of fetal and placental metabolism in drug clearance. Dr. Quinney’s laboratory also studies complex drug-drug interactions, including multi-drug interactions with cytochrome P450 enzymes. In collaboration with Dr. Lang Li, a novel method for drug-drug interaction discovery was developed through integration of large electronic medical record data analysis with in vitro validation. Dr. Quinney has recently received R01 funding to investigate high-dimensional drug interactions using bioinformatics and in vitro approaches. Through her role in the Disease and Therapeutic Response Modeling Program, Dr. Quinney has established collaborations to develop pharmacokinetic models of herbal-drug interactions, evaluate the preclinical pharmacokinetics of drugs in Alzheimer’s Disease, and understand the effects of exercise on pharmacokinetics.
Obstetrics And Gynecology
950 W. Walnut St., R2 476 OBGY
Indianapolis, IN 46202
Titles & Appointments
- Associate Professor of Medicine
- Adjunct Associate Professor of Health Informatics, School of Informatics and Computing
The Obstetric Clinical Pharmacology Lab, directed by Dr. Quinney provides laboratory space and resources to conduct a variety of basic and translational study techniques related to therapeutics in pregnant women. Equipment and expertise is available to conduct a variety of experimental techniques, including cell culture; molecular biology; pharmacogenomic and gene expression analyses; in vitro drug metabolism assays; analytical drug assays; and pharmacokinetic-pharmacodynamic modeling. This laboratory also serves as a resource to support the analysis of clinical study samples
Translational High-Dimensional Drug Interaction Discovery and Validation Using Health Record Databases and Pharmacokinetics Models.
Translational Biomedical Informatics and Pharmacometrics Approaches in the Drug Interactions Research.
Effect of Gastric Fluid Volume on the In Vitro Dissolution and In Vivo Absorption of BCS Class II Drugs: a Case Study with Nifedipine.
International Society of Pharmacometrics