Sara K. Quinney, PhD
Assistant Professor of Obstetrics & Gynecology
My primary focus is the optimization of drug therapy using quantitative models of drug disposition (pharmacokinetics) and action (pharmacodynamics). use pharmacokinetic/pharmacodynamic models, including physiologically based pharmacokinetic models, to integrate in vitro and in vivo data, leading to better understanding of drug disposition and effect. Patient-specific variables including demographic and pharmacogenetic factors are incorporated into the models to identify individuals most likely to respond to drug therapy or who are at most risk of experiencing an adverse event. Also use physiologically-based pharmacokinetic models to examine changes in drug metabolism and disposition in various populations, including pregnant women and children. In addition to pharmacometric analyses, my lab performs both wetlab analyses using a variety of research techniques to evaluate drug metabolism and drug interactions. I have knowledge and experience with conducting clinical trials, pharmacokinetics, and pharmacogenomics. I currently have ongoing clinical studies investigating the pharmacokinetics and pharmacodynamics of nifedipine, betamethasone, methadone, and misoprostol in pregnancy; laboratory research examining drug metabolism by placenta and CYP450-mediated drug interactions; and in silico studies developing PBPK models to investigate changes in drug disposition in pregnancy and localized disposition of anticancer drugs. As the Associate Director of the Indiana CTSI’s Disease and Therapeutic Response Modeling Program, I work with a number of collaborators to develop pharmacometric models.
OBSTETRICS AND GYNECOLOGY
950 W. Walnut St., R2 476 OBGY
Indianapolis, IN 46202
Titles & Appointments
- Assistant Professor of Medicine
The Obstetric Clinical Pharmacology Lab, directed by Drs. Quinney and Patil, provides laboratory space and resources to conduct a variety of basic and translational study techniques related to therapeutics in pregnant women. Equipment and expertise is available to conduct a variety of experimental techniques, including cell culture; molecular biology; pharmacogenomic and gene expression analyses; in vitro drug metabolism assays; analytical drug assays; and pharmacokinetic-pharmacodynamic modeling. This laboratory also serves as a resource to support the analysis of clinical study samples.