Sara K. Quinney

Sara K. Quinney, PhD

Assistant Professor of Obstetrics & Gynecology

Bio

My primary  focus is the optimization of drug therapy using quantitative models of drug disposition (pharmacokinetics) and action (pharmacodynamics). use pharmacokinetic/pharmacodynamic models, including physiologically based pharmacokinetic models, to integrate in vitro and in vivo data, leading to better understanding of drug disposition and effect. Patient-specific variables including demographic and pharmacogenetic factors are incorporated into the models to identify individuals most likely to respond to drug therapy or who are at most risk of experiencing an adverse event. Also use physiologically-based pharmacokinetic models to examine changes in drug metabolism and disposition in various populations, including pregnant women and children. In addition to pharmacometric analyses, my lab performs both wetlab analyses using a variety of research techniques to evaluate drug metabolism and drug interactions. I have knowledge and experience with conducting clinical trials, pharmacokinetics, and pharmacogenomics. I currently have ongoing clinical studies investigating the pharmacokinetics and pharmacodynamics of nifedipine, betamethasone, methadone, and misoprostol in pregnancy; laboratory research examining drug metabolism by placenta and CYP450-mediated drug interactions; and in silico studies developing PBPK models to investigate changes in drug disposition in pregnancy and localized disposition of anticancer drugs.  As the Associate Director of the Indiana CTSI’s Disease and Therapeutic Response Modeling Program, I work with a number of collaborators to develop pharmacometric models.

Connect


(317) 274-2796 


OBSTETRICS AND GYNECOLOGY
950 W. Walnut St., R2 476 OBGY
Indianapolis, IN 46202


  

Titles & Appointments

  • Assistant Professor of Medicine