Xu Lab News

IU School of Medicine researchers discover new potential for functional recovery after spinal cord injury

Researchers at Indiana University School of Medicine have successfully reprogrammed a glial cell type in the central nervous system into new neurons to promote recovery after spinal cord injury—revealing an untapped potential to leverage the cell for regenerative medicine.

IU School of Medicine  |  Mar 05, 2021

Boosting recovery: Scientists study link between energy levels, spinal cord injury

INDIANAPOLIS—Each year, thousands of people in the United States experience a spinal cord injury, damaging the system of nerves that the brain and body use to communicate. A team of researchers from Indiana University School of Medicine, in collaboration with the National Institute of Neurological Disorders and Stroke, have investigated how boosting energy levels within […]

IU School of Medicine  |  Mar 03, 2020

Lab Team Accomplishments

Congratulations to Mohammad Faizan Khan for his recent acceptance to attend IU School of Medicine in fall 2022. Mohammad has been a very dedicated undergraduate assistant in our lab. He has contributed data to a number of projects, and we expect his work to appear in future publications. Best of luck in medical school!

Xiangbing Wu, PhD, Wei Wu, PhD, and Lingxiao, PhD, have been promoted to Research Assistant Professors in the Department of Neurological Surgery, effective Sept. 1, 2021. Paula Monje, PhD, Lingxiao Deng, PhD, and Xiao-Ming Xu, PhD, have just published a paper in Frontiers in Cellular Neuroscience on June 18, 2021 (doi: 10.3389/fncel.2021.690894). The title of the paper is “Human Schwann cell transplantation for spinal cord injury: prospects and challenges in translational medicine”. In this review paper, we introduce the historical progression of the work that supports existing and prospective clinical initiatives and explain the reasons for the choice of human Schwann cells while also addressing the limitations as cell therapy produces.

Congratulations to Wei Wu, PhD, a research associate of neurological surgery, who has received a two-year grant from the Indiana Traumatic Spinal Cord and Brain Injury Research Fund (ISCBIRF) with a total budget of $120,000 between 07/01/2021 and 06/30/2023. The title of the project is: "A polypharmacological strategy to promote regeneration and recovery of function after cervical spinal cord injury.” The goal of this study is to determine whether a multiple kinase inhibitor RO48 promotes greater axonal regrowth and functional recovery than those that target only a single factor after SCI.

Congratulations to Naikui Liu, MD, PhD, a research associate professor of neurological surgery, who has received a two-year grant from the Indiana Traumatic Spinal Cord and Brain Injury Research Fund (ISCBIRF) with a total budget of $120,000 between 07/01/2021 and 06/30/2023. The title of the project is: “Role of alterations of mitochondrial lipids in the pathogenesis of spinal cord injury.” The goal of this study is to determine whether alteration of mitochondrial lipids plays a key role in the progression of secondary SCI and whether mitochondrial lipids can serve as new targets for therapeutic intervention.

Congratulations to Lingxiao Deng, PhD, a research associate of neurological surgery, who has received a two-year grant from the Indiana Traumatic Spinal Cord and Brain Injury Research Fund (ISCBIRF) with a total award of $120,000 between 07/01/2021 and 06/30/2023. The title of the project is: “Combination of locomotor training and Schwann cell transplantation to promote the micturition function after contusive spinal cord injury.” The goal of this study is to determine whether a combination of locomotor training, SCs transplantation and ChABC administration promotes supraspinal axonal regeneration and urination function after contusive SCI.