The research lab of Ahmad R. Safa, PhD, studies the molecular and biochemical mechanisms of intrinsic and acquired resistance to chemotherapeutic drugs, apoptosis (cell death) in cancer cells, cancer stem cells, drug discovery and development, and cancer treatment. His lab is particularly interested in multi-targeted therapy of brain cancer, breast cancer and pancreatic tumors through modulation of the death receptor signaling pathway in cancer cells.
Active Research
The major focus of Safa’s research lab is to target multiple signaling pathways in glioblastoma (GBM), breast cancer, and pancreatic cancer cells and cancer stem cells (CSCs) to eradicate drug-sensitive and -resistant cells. Particularly, the lab team is interested in mechanisms of intrinsic and acquired resistance to chemotherapeutic agents and investigating molecular mechanisms of drug-induced apoptosis.