The research lab of Sophie Paczesny, MD, PhD, is developing non-invasive blood tests integrating both proteomic and cellular biomarkers for the diagnosis and prognosis of GVHD, GVL and antitumoral responses. The laboratory has also focused on immunotherapy to treat leukemia. In the hematopoietic cell transplantation field, T cells play a major role in the GVL effect, which can eradicate tumor cells in patients who resist chemotherapy. The laboratory has recently demonstrated that IL33/ST2 pathway triggering in IL-9-secreting T cells decreases GVHD while maintaining tumor immunity through an enhanced GVL effect.
Areas of Focus
The Paczesny Lab is focused on three primary areas of medical research.