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Faculty Research Labs

Gupta Lab

The laboratory of Kunal Gupta, MD, PhD, works to understand the mechanisms responsible for pathological and therapeutic remodeling in the development of epilepsy. Working primarily using animal models, we study the function of different genes and molecular pathways responsible for the development of mesial temporal lobe epilepsy, the most common form of focal epilepsy. The goal of our lab is to discover novel therapeutic targets that might prevent the development of epilepsy or recurrence after epilepsy surgery.

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Active Research

In our lab, we use mouse models of temporal lobe epilepsy to investigate pathological remodeling in the epileptogenic zone and connected seizure network, to determine the biological basis for the formation of these critical clinical regions. We do this by investigating:

  1. Adult hippocampal epileptogenesis
  2.  Region-specific gene pathway dysregulation
  3. Therapeutic molecular pathway modulation

We have previously determined that the Wnt pathway is dysregulated early in epileptogenesis in the temporal lobe and that Wnt pathway modulation directly affects pathological remodeling in the hippocampus. Our NIH-funded work will determine if Wnt pathway modulation affects the development of epilepsy in this model. We are also actively investigated other pathways that may be responsible for pathological remodeling during this early critical period.

In our work with use transgenic mutant mouse lines, confocal microscopy, whole animal eletrocorticography, viral vector-based gene modulation, in vivo optogenetics, quantitative gene expression measures and other advanced techniques. Using these multidisciplinary approaches allows us to investigate the earliest events in epileptogenesis at genetic, cellular and whole animal levels. Our long-term goal is to understand neuronal plasticity in epileptogenesis and devise novel targeted therapeutic strategies to prevent the development of epilepsy and post-surgical recurrence.

  • Research Funding

    K12 Research Career Development Award from the NIH/NINDS/NRCDP (PI), “Wnt modulation in epileptogenesis, neuronal plasticity and development of epileptic networks” K12NS080223 2021-2023

    Neurosurgery Research and Education Foundation & Bagan Family Foundation (PI) 2017-2018 NREF120118 “Investigating the Role of Wnts in Seizure-Induced Aberrant Hippocampal Neurogenesis”

  • Recent Publications

    Gupta K, Schnell E. Neuronal network remodeling and Wnt pathway dysregulation in the hippocampal kainate mouse model of temporal lobe epilepsy. PLoS ONE. 2019 Oct 14(10);e0215789. PubMed PMID: 31596871; PubMed Central PMCID: PMC6785072

    NCBI Bibliography

Research Team

52223-Gupta, Kunal

Kunal Gupta, MBBCH, PhD

Assistant Professor of Neurological Surgery

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