The laboratory of Peng-Sheng Chen, MD is part of the Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine at IU School of Medicine. Investigators in this laboratory are focused on advancing science related to cardiac arrhythmias, and they collaborate widely within the institute and provide basic science support to other bench and clinical research programs.
The Peng-Sheng Chen Research Laboratory is interested in studying the mechanisms of ventricular fibrillation, ventricular defibrillation and atrial fibrillation. One area of research focuses on the relationship between autonomic nerve activity and cardiac arrhythmia. The lab’s recent work focuses on translating research findings in the animal laboratory to human patients. For example, methods to record skin sympathetic nerve activities in humans and use the results to non-invasively estimate cardiac sympathetic tone have been developed.
The lab is also studying the mechanisms of ventricular fibrillation. Recent research focused on an ionic channel called small conductance calcium activated K (SK) channels. Researchers in the lab found that SK channels are important sources of repolarization currents in both normal and diseased ventricles. Better understanding of this ionic channel may improve the understanding of ventricular fibrillation and other life-threatening ventricular arrhythmias.
Other recent research interests include the mechanisms by which genetic variations can cause cardiac arrhythmia.