The research lab of Hal E. Broxmeyer, PhD is studying the mechanisms regulating proliferation, survival, self-renewal, metabolism, differentiation and homing/mobilization of hematopoietic, stem and progenitor cells during normal, stressed and disease states at cellular, intracellular and animal levels, as well as gene transfer to influence these functions.
Investigators in the Broxmeyer Lab at IU School of Medicine are interested in blood cell production (hematopoiesis) in the context of normal and abnormal cell regulation as assessed in vitro and in vivo. As a clinical correlate, this laboratory is exploring the use of hematopoietic stem and progenitor cells, especially those from umbilical cord blood, with clinical investigators for transplantation purposes, and the use of cytokines/chemokines for treatment of hematological disorders. His lab also collaborates with other investigators at Indiana University and elsewhere nationally and internationally in these areas as well as in the study of other cancer stem cells and immune cells.
