Atwood Lab Publications and Funding

El Jordi O, Fischer KD, Meyer TB, Atwood BK, Oblak AL, Pan RW, McKinzie DL. Microglial knockdown does not affect acute withdrawal but delays analgesic tolerance from oxycodone in male and female C57BL/6J mice. Advances in Drug and Alcohol Research. In press.

Morris CW, Watkins DS, Pennington T, Doud E, Qi G, Mosley A, Atwood BK, Baucum AJ. Spinophilin limits metabotropic glutamate receptor 5 scaffolding to the postsynaptic density and mediates excessive grooming cell type-specifically. Biological Psychiatry. In press. PMID: 36822932

Haggerty DL, Grecco GG, Huang JY, Doud EH, Moseley AL, Lu H-C, Atwood BK. Prenatal methadone exposure selectively alters protein expression in primary motor cortex: implications for synaptic function. Frontiers in Pharmacology. 14:1124108 (2023). PMID: 36817148.

Moutinho M, Coronel I, Tsai AP, Viana Di Prisco G, Pennington T, Atwood BK, Puntambekar SS, Smith DC, Martinez P, Han S, Lee Y, Lasagna-Reeves CA, Lamb BT, Bissel SJ, Nho K, Landreth GE. TREM2 splice isoforms increase in Alzheimer’s disease and generate soluble TREM2 which disrupts long-term potentiation. Genome Medicine. In press.

Grecco GG, Haggerty DL, Reeves KC, Gao Y, Maulucci D, Atwood BK. Prenatal Opioid Exposure Reprograms the Behavioral Response to Future Alcohol Reward. Addiction Biology. 27(2):e13136 (2022). PMID: 35229956

Grecco GG, Munoz B, Viana Di Prisco G, Doud EH, Fritz BM, Maulucci D, Gao Y, Moseley AL, Baucum AJ, Atwood BK. Prenatal opioid exposure impairs endocannabinoid and glutamate transmission in the dorsal striatum. eNeuro. 9(2):ENEURO.0119-22.2022 (2022). PMID: 35396255

Grecco GG, Huang JY, Muñoz B, Doud EH, Hines CD, Gao Y, Rodriguez B, Moseley AL, Lu H-C, Atwood BK. Sex-Dependent Synaptic Remodeling of the Somatosensory Cortex in Mice With Prenatal Methadone Exposure. Advances in Drug and Alcohol Research. doi.org/10.3389/adar.2022.10400 (2022).

Reeves KC, Shah N, Muñoz B, Atwood BK. Opioid receptor-mediated regulation of neurotransmission in the brain. Frontiers in Molecular Neuroscience. 15:919773 (2022). PMID: 35782382

Haggerty DL, Muñoz B, Pennington T, Grecco GG, Fritz BM, Atwood BK. Anterior insular cortex inputs to the dorsolateral striatum govern the maintenance of binge alcohol drinking. eLife. 11:e77411 (2022). PMID: 36098397. Selected for eLife “Insights” editorial.

Martinez P, Patel H, You Y, Jury N, Perkins A, Lee-Gosselin A, Taylor X, You Y, Viana Di Prisco G, Huang X, Dutta S, Wijeratne A, Redding-Ochoa J, Shahid SS, Codocedo JF, Min S, Landreth GE, Mosley AL, Wu Y-C, McKinzie D, Rochet C, Zhang J, Atwood BK, Troncoso J, Lasagna-Reeves CA. Bassoon contributes to tau-seed neurotoxicity and propagation. Nature Neuroscience. 25(12):1597-1607 (2022). PMID: 36344699

Muñoz B, Fritz BM, Yin F, Atwood BK.  HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum. Journal of Physiology. 600(22):4917-4938 (2022). PMID: 36181477

Grecco GG, Shahid S, Atwood BK, Wu Y-C. Alterations of Brain Microstructures in a Mouse Model of Prenatal Opioid Exposure Detected by Diffusion MRI. Scientific Reports. 12(1):17085 (2022). PMID: 36224335

Simmons SC, Grecco GG, Atwood BK, Nugent FS. Effects of Prenatal Opioid Exposure on Synaptic Plasticity and Behaviors Across Development. Neuropharmacology. 222:109312 (2022). PMID: 36334764

Grecco GG, Haggerty DL, Doud E, Fritz BM, Hoffman H, Mosely A, Simpson E, Liu Y, Baucum AJ, Atwood BK. A Multi-Omic Analysis of the Dorsal Striatum in an Animal Model of Divergent Genetic Risk for Alcohol Use Disorder. J. Neurochem. 157(4):1013-1031. (2021). PMID: 33111353

Kramer NB, Ross RA, Fenselau H, DQ, Haggerty DL, Atwood B, Lowell B, Flak JN. The Role of Ventromedial Hypothalamic PACAP in the Control of Body Weight and Metabolism. Endocrinology. 162(4):bqab012 (2021). PMID: 33460433

Fritz BM, Yin F, Atwood BK. Input-Selective Adenosine A1 Receptor-Mediated Synaptic Depression of Excitatory Transmission in Dorsal Striatum. Scientific Reports. 11(1):6345 (2021). PMID: 33737568

Grecco GG, Mork B, Huang JY, Metzger CE, Haggerty DL, Reeves KC, Gao Y, Hoffman H, Katner SN, Masters AR, Morris CW, Newell EA, Baucum, AJ Engleman EA, Kim J, Yamamoto BK, Allen MR, Wu YC, Lu HC, Sheets PL, Atwood BK. Prenatal Methadone Exposure Disrupts Behavioral Development and Alters Motor Neuron Intrinsic Properties and Local Circuitry. eLife. 10:e66230 (2021). PMID: 33724184.

Grecco GG, Gao Y, Gao H, Liu Y, Atwood BK. Prenatal Opioid Administration Induces Shared Alterations to the Maternal and Offspring Gut Microbiome. Drug and Alcohol Dependence. 227:108914 (2021). PMID: 34364194

Centanni S, Janes AC, Haggerty DL, Atwood BK, Hopf FW. Better living through understanding the insula: why subregions can make all the difference. Neuropharmacology. 198:108765 (2021). PMID: 34461066

Karahan H, Smith D, Kim B, El-Amin MM, Dabin L, Pennington T, Viana di Prisco G, McCord B, Lin P, Atwood BK, Oblak A, Kim J. Deletion of Abi3 gene exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis. Science Advances. 7(45):eabe3954 (2021). PMID: 34731000

Munoz B, Haggerty DL, Atwood BK. Synapse-specific expression of mu opioid receptor long-term depression in the dorsomedial striatum. Scientific Reports. 10(1):7234 (2020).PMID: 32350330

Mulcahy G, Atwood B, Kuznetsov A. Basal Ganglia role in learning reward actions and executing previously learned choices: Healthy and diseased states.PLoS One. 2020 Feb 10;15(2):e0228081. PMID: 32040519

Reeves KC, Kube MJ, Grecco GG, Fritz BM, Muñoz B, Yin F, Gao Y, Haggerty DL, Hoffman HJ, Atwood BK. Mu opioid receptors on vGluT2-expressing glutamatergic neurons modulate opioid reward. Addiction Biology. Jul 20:e12942 (2020). PMID: 32686251

Cisternas P, Taylor X, Perkins A, Maldonado O, Allman E, Cordova R, Marambio Y, Munoz B, Pennington T, Xiang S, Zhang J, Vidal R, Atwood B, Lasagna-Reeves CA. Vascular amyloid accumulation alters the gabaergic synapse and induces hyperactivity in a model of cerebral amyloid angiopathy. Aging Cell. (2020). 19(10):e13233. PMID: 32914559

Jadhav VS, Lin PB, Xu G, Pennington T, Viana Di Prisco G, Jacob A, Moutinho M, Puntambekar SS, Zhang J, Atwood BK, Bissel SJ, Oblak AL, Landreth GE, Lamb BT. Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses with age. Molecular Neurodegeneration. 15(1):62 (2020). PMID: 33115519

Radhakrishnan R, Grecco G, Stolze K, Atwood BK, Jennings SG, Lien IZ, Saykin AJ, Sadhasivam S. Early Neuroimaging in Infants with Prenatal Opioid Exposure: Insights and Recent Developments. Journal of Neuroradiology. 13:S0150-9861(20)30278-9 (2020). PMID: 33065196

Grecco GG, Atwood BK. Prenatal Opioid Exposure Enhances Responsiveness to Future Drug Reward and Alters Sensitivity to Pain: A Review of Preclinical Models and Contributing Mechanisms. eNeuro. ENEURO.0393-20.2020 (2020) PMID: 33060181

Haggerty DL, Grecco GG, Reeves K, Atwood BK. Adeno-associated viral vectors in neuroscience research. Molecular Therapy - Methods and Clinical Development. 17:69-82 (2019). PMID: 31890742

Fritz BM, Munoz B, Atwood BK. Genetic Selection for Alcohol Preference in Mice Alters Dorsal Striatum Neurotransmission. Alcoholism: Clinical and Experimental Research. 43 (11):2312-2321 (2019). PMID: 31491046.

Jay T, von Saucken VE, Muñoz B, Codocedo JF, Atwood BK, Lamb BT, Landreth GE. The neurodegeneration-associated receptor TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment. Glia. 67(10):1873-1892 (2019). PMID: 31265185.

You Y, Perkins A, Cisternas P, Muñoz B, Taylor X, You Y, Garringer HJ, Oblak AL, Ghetti B, Atwood BK, Vidal R, Lasagna-Reeves C. Tau as a mediator of neurotoxicity associated to Cerebral Amyloid Angiopathy. Acta Neuropathologica Communications. 7(1):26 (2019). PMID: 30808415.

Munoz, B., Fritz, B.M., Yin, F., Atwood, B.K.  Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum. Nature Communications. In press.

Fritz, B.M., Munoz, B., Yin, F., Bauchle, C., Atwood, B.K. A high-fat, high-sugar ‘western’ diet alters dorsal striatal glutamate, opioid, and dopamine transmission in mice. Neuroscience, Epub December 28, 2017. PMID: 29289718.

Mateo, Y., Johnson, K., Covery, D.P., Atwood, B.K., Wang, H.-L., Zhang, S., Gildish, I., Cachope, R., Bellocchio, L., Guzman, M., Morales, M., Cheer, J., Lovinger, D. M. Endocannabinoid Actions on Cortical Terminals Orchestrate Local Modulation of Dopamine Release in the Nucleus Accumbens. Neuron, 96(5):1112-1126 (2017). PMID: 29216450

Atwood, B.K., Lovinger, D.M. Endocannabinoid-Dependent Synaptic Plasticity in the Striatum. Endocannabinoids and Lipid Mediators in Brain Functions. 109-153 (2017)

Gremel, C., Chancey, J., Atwood, B.K., Luo, G., Neve, R., Ramakrishnan, C., Deisseroth, K., Lovinger, D.M., Costa, R. Endocannabinoid modulation of orbitostriatal circuits gates habit formation. Neuron. 90(6):1312-1324 (2016). PMID: 27238866

Atwood, B.K., Lovinger, D.M., Mathur, B.M. Presynaptic long-term depression mediated by Gi/o-coupled receptors. Trends in Neurosciences. 37(11): 663-673 (2014). PMID: 25160683

Atwood, B.K., Kupferschmidt, D.A., Lovinger, D.M. Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum. Nature Neuroscience. 17(4): 540-548 (2014). PMID: 24561996

Atwood, B.K., Wager-Miller, J., Haskins, C., Straiker, A, Mackie, K. Functional selectivity in CB(2) cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB(2) ligands. Molecular Pharmacology. 81(2): 250-263 (2012). PMID: 22064678

Atwood, B.K., Straiker A., Mackie, K. CB(2) cannabinoid receptors inhibit synaptic transmission when expressed in cultured autaptic neurons. Neuropharmacology. 63(4): 514-523 (2012). PMID: 22579668

Atwood, B.K., Straiker, A., Mackie, K. CB(2): Therapeutic target-in-waiting. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 38(1): 16-20 (2012). PMID: 22197668

Atwood, B.K., Lopez, J., Wager-Miller, J., Mackie, K., Straiker, A. Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis. BMC Genomics. 12:14. (2011). PMID: 21214938

Atwood, B.K., Lee, D., Straiker, A., Widlanski, T.S., Mackie, K. CP47,497-C8 and JWH073, commonly found in ‘Spice’ herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonists. European Journal of Pharmacology. 659(2-3): 139-145 (2011). PMID: 21333643

Atwood, B.K., Mackie, K. CB2: a cannabinoid receptor with an identity crisis. British Journal of Pharmacology. 160(3): 467-479 (2010). PMID: 20590558

Atwood, B.K., Huffman, J., Straiker, A., Mackie, K. JWH018, a common constituent of ‘Spice’ herbal blends, is a potent and efficacious cannabinoid CB receptor agonist. British Journal of Pharmacology. 160(3): 585-593 (2010). PMID: 20100276

NIH/NIAAA                                

A novel proteomics approach to identify alcohol-induced changes in synapse-specific presynaptic protein interactions.

05/05/2023-04/30/2025

Role: MPI w/ AJ Baucum

NIH/NIAAA        

Synapse-specific interactions between ethanol and opioid receptor-mediated synaptic depression in dorsal striatum

09/20/2018-08/31/2023                                    

Role: PD/PI

NIH/NIA

Tau-seed protein interactome and its role in neurodegenerative tauopathies.

09/30/2020-08/31/2025

Role: Co-investigator

NIH/NIA

The role of ABI3 in Alzheimers disease.

9/15/2021-08/31/2024

Role: Co-investigator

NIH/NIAAA                             

Anterior insular cortex to dorsolateral striatum neural circuit regulation of binge drinking and habitual behaviors

01/01/2022-03/31/2025

Role: Primary Sponsor/Mentor for Graduate Student David Haggerty 

NIH/NIA                                                                  

The IU/JAX Alzheimer's Disease Precision Models Center

9/30/2022-8/31/2027

Role: Co-investigator