Alpini Lab

The Alpini Lab, led by Gianfranco Alpini, PhD, evaluates the regulation of cholangiocyte proliferation/damage during the progression of cholangiopathies, the chronic diseases that target intrahepatic cholangiocytes. Proliferating cholangiocytes display a neuroendocrine phenotype and secrete and respond to a number of hormones, neuropeptides and neurotransmitters in autocrine and paracrine signaling mechanisms.

The research interests of the Alpini Lab also include determining the interactions that occur between cholangiocytes and other cell types (such as hepatocytes, hepatic stellate cells and vascular endothelial cells) in the biliary microenvironment during both cholestasis and cholangiocarcinogenesis. The lab evaluates the various signaling mechanisms regulating the balance between cellular proliferation/cellular senescence and apoptosis.

Research Updates

To stay current on the medical research work at IU School of Medicine’s statewide campuses, follow the IU School of Medicine research blog, where investigators throughout the school’s academic departments post updates about their work.

Research Updates Blog

Published Work

View a complete list of published work by the Alpini Laboratory.