Type 2 Diabetes
According to the American Diabetes Association, diabetes is a particularly serious problem in Indiana, where more than 695,000 children and adults in Indiana suffer from all forms of diabetes, including Type 1, Type 2 and gestational diabetes––with Type 2 diabetes being the most prevalent. The IU Precision Health Initiative’s Type 2 diabetes research team is focused on the prevention and progression of this chronic disease, especially in women with gestational diabetes, who are at a higher risk for developing Type 2 diabetes within five to 10 years later. The team is currently analyzing the genetics of 10,000 pregnant women through blood samples made available through the NIH’s nuMoM2b study to study what biological factors led some of the women to develop Type 2 diabetes. Researchers are also investigating RNA to better understand the environmental components of the disease. Prevention studies in people at higher risk of developing Type 2 diabetes will be focused on identifying and overcoming individual factors that interfere with treatment.
The diabetes team is led by IU School of Medicine’s Raghu Mirmira, MD, PhD; Kieren Mather, MD; and David Haas, MD.