Physical activity and nutrition and exercise, focusing on lifestyle, nutrition and behavioral modifications that impact musculoskeletal health and physical function, especially in regards to nutrition and mobility that lead to a healthier individual. Understanding how musculoskeletal disorders affect overall population health and how chronic diseases impact musculoskeletal health.
Cancer in bone and muscle, focusing on preventing or curing sarcoma multiple myeloma, breast and prostate cancer in bone.
Trauma, regeneration, rehabilitation, focusing on muscle and bone injuries, tissue regeneration and patient rehabilitation.
Genetic and endocrine diseases, precision medicine, focusing on treatment of genetic bone disease, chronic kidney disease and diabetes.
A world leader in research related to hypophosphatemic rickets – a group of rare bone conditions caused by low phosphate levels – researchers at IU School of Medicine have pioneered new therapies for children and adolescents suffering from these disorders.
Mechanobiology and muscle/bone crosstalk, focusing on basic musculoskeletal biology and the effects of exercise on the musculoskeletal system, especially in relation to obesity, and the new research area of non-mechanical, systemic interactions between muscle and bone.
Pediatric musculoskeletal disease, focusing on childhood diabetes, genetic bone disease osteosarcoma and dystrophies.
Musculoskeletal Health Research Faculty
Indiana Center for Musculoskeletal Health
Bone Healing in Space
An elite group of more than 40 scientists and clinicians are working on musculoskeletal research. Collaborators with IU School of Medicine include IU School of Dentistry, Purdue School of Engineering and Technology, School of Health and Rehabilitation Sciences and other schools at IUPUI. This depth and breadth of expertise enables collaborative efforts that are the hallmark of modern biomedical research, as teams can approach problems at all points on a continuum from the molecular and cellular to surgical to rehabilitation.
IU School of Medicine scientists and partners are also able to interact with a strong community of private industry musculoskeletal health researchers at Indiana’s cluster of orthopaedic products companies in Warsaw and with tissue engineering experts at Cook Biotech in West Lafayette, and researchers involved with osteoporosis and bone biomarker work at Eli Lilly and Co. and Roche Diagnostics in Indianapolis.
The Indiana Cores Center for Clinical Research is a federally funded center created to enhance clinical research in musculoskeletal disorders and to better understand the muscle-bone connection. The center leverages the resources of institutions across Indiana for initiatives that will enable Indiana University School of Medicine musculoskeletal researchers to identify novel targets for diagnosis and treatment of musculoskeletal disorders with a focus on precision medicine approaches.