26650-Koyama, Sachiko
Faculty

Sachiko Koyama, PhD, MA

Assistant Research Professor of Medicine

Email sakoyama@iu.edu
Address
950 W Walnut St R2
NEPH
IN
Indianapolis, IN 47405-7005
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Bio

Dr. Sachiko Koyama obtained her Ph.D. from the University of Tokyo in 1995. She specializes in the influences of chemical compounds (of animal origin such as pheromones and plant origin, i.e., phytochemicals) with bioactive properties on physiological conditions. In her recent study, she found the effects of a phytochemical compound beta-caryophyllene on facilitating cutaneous re-epithelialization, which became press released from multiple sources. Utilizing murine pheromones, she has identified multiple phenomenon that pheromones cause impacts, such as on sperm activity and sperm density, brain cell proliferation/neurogenesis, mammary gland expansion, and the trans-generational influences of such exposure. She is a member of the Global Consortium for Chemosensory Research (GCCR) where she participates in multiple projects related to the chemical senses (olfaction and taste). She is also leading a GCCR project on the use of phytochemicals with bioactive properties in facilitating recovery from chemosensory dysfunction. She is a member of the DEI committee of the consortium as well. She has strong interest in utilizing phytochemicals in facilitating recovery from injuries and diseases, and in improving health conditions.

Titles & Appointments

  • Assistant Research Professor of Medicine
  • Education
    1995 PhD University of Tokyo
    1980 MA Osaka University
    1978 BA Tokyo Woman's Christian University
  • Research

    Compared to defects in vision or hearing, hypo/anosmia (loss of olfactory sense) has received less attention because of its less serious effect on daily life activities compared to blindness or deafness.  However, the dysfunction in olfactory sense often accompanies inabilities to appreciate food and to notice rotten food or toxic gas. Thus, studies on olfactory sense may significantly improve the quality of our life. Our physiological conditions are also more affected by the odor of people around us than we recognize.  Studies from 1970s have shown that women who live together and spend time together show synchronized menstrual cycles and recent studies have shown that hormone secretions are stimulated by exposure to the odors of opposite sex. In my recent studies, I have found in mice that sperm density is higher in male mice exposed to female-soiled bedding (Koyama and Kamimura 2000) and subordinate males show lower sperm motility (1999).  

     

    In collaboration with analytical chemists in the Chemistry Department of IUB, I have also identified the male murine pheromones that enhance cell proliferation in the subventricular zone in the brain of female mice and female murine pheromones that do so in male mice (Koyama et al. 2013, 2014).  

     

    We also found a new phenomenon for which exposure to a synthetic analogue of the male murine pheromone stimulates expansion of mammary glands in female mice and the offspring of these females showed higher cognitive function in spatial memory tests using a Morris water maze (Koyama et al. 2015) (Press release at IUB News Room: http://news.indiana.edu/releases/iu/2015/07/pheromone-intelligence-study.shtml).  

     

    We are currently investigating the milk of these dams and the brain development in their offspring to obtain molecular mechanistic insight into the pheromone induced trans-generational influences. 

     

    Another project we started is focusing on odorants (aromas) rather than pheromones and their influences on improving wound healing.  We hope to determine the odorants that enhance wound healing and suppress neuropathic pain.

     

    Patent application Chemical component attractant for mice: Patent application number: JA03046, Japan

  • Publications
    Chemical Constituents of Essential Oils Used in Olfactory Training: Focus on COVID-19 Induced Olfactory Dysfunction.
    Koyama S; Heinbockel T; Frontiers in pharmacology 2022 Jun 2
    Insight into the mechanisms of olfactory dysfunction by COVID-19.
    Koyama S; Mori E; Ueha R; Auris, nasus, larynx 2022 Dec 9
    A follow-up on quantitative and qualitative olfactory dysfunction and other symptoms in patients recovering from COVID-19 smell loss.
    Ohla K; Veldhuizen MG; Green T; Hannum ME; Bakke AJ; Moein ST; Tognetti A; Postma EM; Pellegrino R; Hwang DLD; Albayay J; Koyama S; Nolden AA; Thomas-Danguin T; Mucignat-Caretta C; Menger NS; Croijmans I; Öztürk L; Yanik H; Pierron D; Pereda-Loth V; Nunez-Parra A; Martinez Pineda AM; Gillespie D; Farruggia MC; Cecchetto C; Fornazieri MA; Philpott C; Voznessenskaya V; Cooper KW; Rohlfs Dominguez P; Calcinoni O; de Groot J; Boesveldt S; Bhutani S; Weir EM; Exten C; Joseph PV; Parma V; Hayes JE; Niv MY; Rhinology 2022 Apr 10
    Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms.
    Gerkin RC; Ohla K; Veldhuizen MG; Joseph PV; Kelly CE; Bakke AJ; Steele KE; Farruggia MC; Pellegrino R; Pepino MY; Bouysset C; Soler GM; Pereda-Loth V; Dibattista M; Cooper KW; Croijmans I; Di Pizio A; Ozdener MH; Fjaeldstad AW; Lin C; Sandell MA; Singh PB; Brindha VE; Olsson SB; Saraiva LR; Ahuja G; Alwashahi MK; Bhutani S; D'Errico A; Fornazieri MA; Golebiowski J; Dar Hwang L; Öztürk L; Roura E; Spinelli S; Whitcroft KL; Faraji F; Fischmeister FPS; Heinbockel T; Hsieh JW; Huart C; Konstantinidis I; Menini A; Morini G; Olofsson JK; Philpott CM; Pierron D; Shields VDC; Voznessenskaya VV; Albayay J; Altundag A; Bensafi M; Bock MA; Calcinoni O; Fredborg W; Laudamiel C; Lim J; Lundström JN; Macchi A; Meyer P; Moein ST; Santamaría E; Sengupta D; Rohlfs Dominguez P; Yanik H; Hummel T; Hayes JE; Reed DR; Niv MY; Munger SD; Parma V; GCCR Group Author; Chemical senses 2021 Jan 1
    Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia.
    Koyama S; Kondo K; Ueha R; Kashiwadani H; Heinbockel T; International journal of molecular sciences 2021 Aug 18
    Loss of Smell and Taste in Patients With Suspected COVID-19: Analyses of Patients' Reports on Social Media.
    Koyama S; Ueha R; Kondo K; Journal of medical Internet research 2021 Apr 22
    More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis.
    Parma V; Ohla K; Veldhuizen MG; Niv MY; Kelly CE; Bakke AJ; Cooper KW; Bouysset C; Pirastu N; Dibattista M; Kaur R; Liuzza MT; Pepino MY; Schöpf V; Pereda-Loth V; Olsson SB; Gerkin RC; Rohlfs Domínguez P; Albayay J; Farruggia MC; Bhutani S; Fjaeldstad AW; Kumar R; Menini A; Bensafi M; Sandell M; Konstantinidis I; Di Pizio A; Genovese F; Öztürk L; Thomas-Danguin T; Frasnelli J; Boesveldt S; Saatci Ö; Saraiva LR; Lin C; Golebiowski J; Hwang LD; Ozdener MH; Guàrdia MD; Laudamiel C; Ritchie M; Havlícek J; Pierron D; Roura E; Navarro M; Nolden AA; Lim J; Whitcroft KL; Colquitt LR; Ferdenzi C; Brindha EV; Altundag A; Macchi A; Nunez-Parra A; Patel ZM; Fiorucci S; Philpott CM; Smith BC; Lundström JN; Mucignat C; Parker JK; van den Brink M; Schmuker M; Fischmeister FPS; Heinbockel T; Shields VDC; Faraji F; Santamaría E; Fredborg WEA; Morini G; Olofsson JK; Jalessi M; Karni N; D'Errico A; Alizadeh R; Pellegrino R; Meyer P; Huart C; Chen B; Soler GM; Alwashahi MK; Welge-Lüssen A; Freiherr J; de Groot JHB; Klein H; Okamoto M; Singh PB; Hsieh JW; GCCR Group Author; Reed DR; Hummel T; Munger SD; Hayes JE; Chemical senses 2020 Oct 9
    Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic.
    Vihani A; Hu XS; Gundala S; Koyama S; Block E; Matsunami H; eLife 2020 Nov 24
    The Effects of Essential Oils and Terpenes in Relation to Their Routes of Intake and Application.
    Koyama S; Heinbockel T; International journal of molecular sciences 2020 Feb 25
    Endurance training slows breast tumor growth in mice by suppressing Treg cells recruitment to tumors.
    Hagar A; Wang Z; Koyama S; Serrano JA; Melo L; Vargas S; Carpenter R; Foley J; BMC cancer 2019 Jun 4
    Beta-caryophyllene enhances wound healing through multiple routes.
    Koyama S; Purk A; Kaur M; Soini HA; Novotny MV; Davis K; Kao CC; Matsunami H; Mescher A; PloS one 2019 Dec 16
    Estrogen modulates mesenchyme-epidermis interactions in the adult nipple.
    Wu HJ; Oh JW; Spandau DF; Tholpady S; Diaz J 3rd; Schroeder LJ; Offutt CD; Glick AB; Plikus MV; Koyama S; Foley J; Development (Cambridge, England) 2017 Mar 13
    Cross-generational impact of a male murine pheromone 2-sec-butyl-4,5- dihydrothiazole in female mice.
    Koyama S; Soini HA; Wager-Miller J; Alley WR; Pizzo MJ; Rodda C; Alberts J; Crystal JD; Lai C; Foley J; Novotny MV; Proceedings. Biological sciences 2015 Jul 22
    The nipple: a simple intersection of mammary gland and integument, but focal point of organ function.
    Koyama S; Wu HJ; Easwaran T; Thopady S; Foley J; Journal of mammary gland biology and neoplasia 2013 May 15
    Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones.
    Koyama S; Soini HA; Foley J; Novotny MV; Lai C; Frontiers in behavioral neuroscience 2013 Aug 6
    Comparison of urinary scents of two related mouse species, Mus spicilegus and Mus domesticus.
    Soini HA; Wiesler D; Koyama S; Féron C; Baudoin C; Novotny MV; Journal of chemical ecology 2009 Apr 24
    Chemotaxis assays of mouse sperm on microfluidic devices.
    Koyama S; Amarie D; Soini HA; Novotny MV; Jacobson SC; Analytical chemistry 2006 May 15
    Chemical identification of MHC-influenced volatile compounds in mouse urine. I: Quantitative Proportions of Major Chemosignals.
    Novotny MV; Soini HA; Koyama S; Wiesler D; Bruce KE; Penn DJ; Journal of chemical ecology 2006 Dec 27
    Primer effects by conspecific odors in house mice: a new perspective in the study of primer effects on reproductive activities.
    Koyama S; Hormones and behavior 2004 Sep
  • Clinical Interests

    I am interested in utilizing odorants (aromas and pheromones) to improve our health conditions and treat or enhance the treatment of wounds, diseases, stress, and anxieties.  

    Selected book publications

    Single authored books

     

    • Koyama, S., 2016. Primer Effects by Murine Pheromone Signaling. Springer International Publishing AG, Vienna, Austria. ISBN 978-3-319-13932-6, ISBN (ebook) 978-3-319-13933-3, Doi 10.1007/978-3-319-13933-3
    • Koyama, S. 2008. Ethology of Olfactory Communication in Animals.  Fragrance Journal Inc., Tokyo, Japan (in Japanese). ISBN 978-4-89479-134-3, e-book: 2014
    • Koyama, S. 1999 The History and Mechanism of Tricks using Varied Tits in Japan. Housei University Press, Tokyo (in Japanese).  ISBN978-4-588-76207-9(4-588-76207-9) C0045
    • “Koyama, S. 1999 The History and Mechanism of Tricks using varied tits in Japan. Hosei University Press” was used in the entrance examination on Japanese literature by Kaetu University, Japan, in 2007, spring. 
    • “Koyama, S. 1999 The History and Mechanism of Tricks using varied tits in Japan. Hosei University Press” received reviews on Sunday Book Review Column of major news papers: Yomiuri Shinbun (10/17/1999), Tokyo Shinbun (11/21/1999), Saitama Shinbun (11/07/1999); journals: Publication News, 1999, vol. 11, p.19, Wild Birds, 2000, no.627, p.20, Heredity, 2000, vol.54 (7), p.106-107, Siesta, 2000, Winter, p.20-21, Relatio, 2001, vol.10, p.105 

     

    Chapters of books (selected)

     

    • Koyama, S. 2010 Establishment and management of individual relationships: pair-bonding and social play behaviors. In Yasuhiko Kondo et al. eds Behavioral Neuroendocrinnology. Nishimura-shoten, Tokyo, Japan (in Japanese). ISBN?978-4-89013-396-3
    • Koyama, S. 2007 Mechanisms of olfactory communication in rodents. In Tatsuaki Shibuya, Masumi Ichikawa eds The science of smells and odours. Asakura Shoten, Shinjuku, Japan, pp. 210-216 (in Japanese).  ISBN 9784254102079(4254102070)
    • Koyama, S. 2007 History of keeping small birds and bird song contests in Japan. In The Association of Japanese University Presses ed. The Time of Natural History. The Association of Japanese University Presses, Tokyo, Japan, pp.42-44 (in Japanese).
    • Koyama, S. & Kamimura, S. 2005, Soiled bedding from group-housed females exerts strong influence on male reproductive condition. In: R.T. Mason, M.P. LeMaster, and D.Müller-Schwarze eds, Chemical Signals in Vertebrates. Kluwer Academic/ Plenum Publishers, New York, pp. 168-172. ISBN: 978-0-387-25159-2 (Print) 978-0-387-25160-8 (Online)
    • Koyama, S. 2002 The history and mechanism of tricks using varied tits. In: K. Ueda & O. Sakura eds. Curious Behaviors of Animals (1). Shokabo, Co., Tokyo, 151-161 (in Japanese). ISBN: 4-7853-8743-2
    • Koyama, S. & Kamimura, S. 2001, Effects of social dominance and female odour on sperm activity of male mice. In: A. Marchlewska-Koj, J.J.Lepri, and D.Muller-Schwarze eds, Chemical Signals in Vertebrates. Kluwer Academic/ Plenum Publishers, New York, pp. 403-410. ISBN: 978-1-4613-5187-0 (Print) 978-1-4615-0671-3 (Online)

     

     

    Selected research publications (after 1999)

     

    • Koyama, S., Soini, H.A., Wager-Miller, J., Alley, W.R., Pizzo, M.J., Rodda, C., Alberts, J., Crystal, J.D., Lai, C., Foley, J., Novotny, M.V. 2015. Cross-generational Impact of a Male Murine Pheromone 2-sec-butyl-4,5-dihydrothiazole in Female Mice. Proceedings of the Royal Society of London B: Biological Sciences.  http://dx.doi.org/10.1098/rspb.2015.1074   This paper received press release on 7/1/2015 on IUB website: http://news.indiana.edu/releases/iu/2015/07/pheromone-intelligence-study.shtml
    • Koyama, S. 2015. History of bird keeping and the teaching of tricks using varied tits (Cyanistes varius) in Japan. Archives of Natural History, 42(2), 211-225.
    • H-J Wu, T. Easwaran, C.D. Offutt, D. Spandau, S. Koyama, J. Foley. 2015. Expansion of specialized epidermis induced by hormonal state and mechanical strain. Mechanisms of Development. pii: S0925-4773(15)00019-2. doi: 10.1016/j.mod.2015.01.002  http://www.ncbi.nlm.nih.gov/pubmed/25680535
    • Koyama, S., Soini, H.A., Foley, J., Novotny, M.V., Lai, C. 2014. Pheromone-induced cell proliferation in the murine subventricular zone. Biochemical Society Transactions. 42(4), 882-885. DOI: 10.1042/BST20140112
    • Koyama, S., Soini, H.A., Foley, J., Novotny, M.V., Lai, C. 2013. Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones. Frontiers in Behavioral Neuroscience. DOI: 10.3389/fnbeh.2013.00101 eCollection 2013. PMID: 23964214 Free PMC Article
    • Koyama, S., Wu, H-J., Easwaran, T., Thopady, S., Foley, J. 2013.  The nipple: A simple intersection of mammary gland and integument, but focal point of organ function. Journal of Mammary Gland Biology and Neoplasia, 18, 121-131.  PMID: 23674217 PubMed
    • Soini, H.A., Wiesler, D., Koyama, S., Féron, C., Baudoin, C., Novotny, MV. 2009 Comparison of uinary scents of two related mouse species, Mus spicilegus and Mus domesticus. Journal of Chemical Ecology, 35 (5), 580-589. PMID: 19390894 PubMed
    • Novotny, MV, Soini, HA, Koyama, S., Wiesler, D., Bruce, KE, Penn, DJ. 2007 Chemical identification of MHC-influenced 4 volatile compounds in mouse urine. I: Quantitative 5 proportions of major chemosignals.  Journal of Chemical Ecology, 33, 417-434.  PubMed
    • Koyama, S., Amarie, D., Soini, H.A., Novotny, M.V., Jacobson, S.C. 2006 Chemotaxis assays of mouse sperm on microfluidic devices. Analytical Chemistry, 78, 3354-3359.  PubMed
    • Koyama, S. 2004 Primer effects by conspecific odours in house mice: a new perspective in the study of primer effects on reproductive activities. Hormones and Behaviour, 46, 303-310. PubMed
    • Aikawa, H., Koyama, S., Matsuda, M., Nakahashi, K., Akazome, Y., Mori, T. 2004 Relief effect of vitamin A on the decreased motility of sperm and the increased incidence of malformed sperm in mice exposed neonatally to Bisphenol A. Cell and Tissue Research, 315, 119-124  PubMed
    • Koyama, S. & Kamimura, S. 2003 Effects of vomeronasal organ removal on the sperm motility in male mice. Zoological Science, 20, 1355-1358.  PubMed
    • Koyama, S. & Kamimura, S. 2003 Study on the developmental changes, variance of sperm motility, and social dominance of male mice. Physiology and Behaviour, 80, 267-272. PubMed
    • Koyama, S. & Kamimura, S. 2000 Influence of social dominance and female odour on the sperm activity of male mice. Physiology and Behaviour, 71, 415-422.  PubMed
    • Koyama, S. & Kamimura, S. 1999 Lowered sperm motility in mice of subordinate social status. Physiology and Behaviour, 65, 665-669. PubMed
    • Selected review publications
    • Koyama, S. 2016. Influences of pheromone on the next generations. Aroma Research, 17(3), 54-57.
    • Koyama, S. 2016. Possible utilization of odorants in medical science. Aroma Research, 17(3), 90-93.
    • Koyama, S. 2016. Primer effects in mice. Aroma Research, 17(2), 92-94.
    • Koyama, S. 2015. Changes in olfactory sensitivity in mice. Aroma Research, 16(3) 86-89.
    • Koyama, S. 2015. Expression of olfactory receptors in skin. Aroma Research, 16(2) 86-89.
    • Koyama, S. 2015. Neurons involved in parental behavior. Aroma Research, 16(1), 79-83.
    • Koyama, S. 2014. Olfactory critical period in mice. Aroma Research. 15(4), 73-77.
    • Koyama, S. 2014. Trans-generational impact of the exposure to odor of acetophenone. Aroma Research, 15(3). 80-83.
    • Koyama, S. 2014 Sexual differences in the responses to pheromones. Aroma Research, 15(1), 85-89.
    • Koyama, S. 2013 Are identical twins the same? Aroma Research, 14(3), 82-85.
    • Koyama, S. 2013 Are there pheromones in mouse milk? Aroma Research, 14(2), 90-93.
    • Koyama, S. 2013 Distinguishing already mated females by pheromone. Aroma Research, 14(1), 85-89.
    • Koyama, S. 2012 Influence of father on menarcheal age. Aroma Research, 13(4), 82-85.
    • Koyama, S. 2012 The Bruce effect in wild gerada. Aroma Research 13(3), 86-89.
    • Koyama, S. 2012 Influence of odors on neurogenesis of mice. Aroma Research, 13(1), 86-89.
    • Koyama, S. 2011 Migration of GnRH neuron from nasal placode to basal forebrain. Aroma Research, 12(3), 88-91.
    • Koyama, S. 2011 Hunger enhances olfactory sense? Aroma Research, 12(2), 87-91
    • Koyama, S. 2010 Vibration theory of olfactory perception. Aroma Research, 11(4), 80-83
    • Koyama, S. 2010 Increase of neurogenesis by pheromone. Aroma Reseasrch, 11(1), 76-77.
    • Koyama, S. 2009 The function of neurogenesis at the subventricular zone of brain. Aroma Research, 10(4), 84-85.
    • Koyama, S. 2009 A new family of vomeronasal chemosensors. Aroma Research, 10(3), 72-73.
    • Koyama, S. 2009 Communication using odors in humansZA. Aroma Research, 10(1), 78-86.
    • Koyama, S. 2006 Development of microfluidic devices for the studies on chemical communication in animals. Aroma Research, 7(3), 80-88.
    • Stockley, P., Koyama, S. 2006 Sperm competition in rodents. Heredity, 60, 60-62.
    • Koyama, S. 2006 Information transfer about food. Aroma Research, 7(2), 88-96.
    • Koyama, S. 2006 Information transfer of odors of the food other animals ate.  Aroma Research, 7(1), 84-90.
    • Koyama, S. 2005 Communication using odors at cell level. Aroma Research, 6(4), 85-93.
    • Koyama, S. 2005 Do birds use odors in their communication? Aroma Research, 6(3), 85-91.
    • Koyama, S. 2005 Pheromone of sea lamprey. Aroma Research, 6(2), 87-92.
    • Koyama, S. 2005 Influence of mice odors on the aggressive behavior of mice. Aroma Research, 6(1), 88-93.
    • Koyama, S. 2005 Influence of mice odors on the mate preference behavior of mice. Aroma Research, 5(3), 76-82.
    • Koyama, S. 2004 Influence of mice odors on the physiological conditions of female mice. Aroma Research, 5(2), 81-87.
    • Koyama, S. 2004 Influence of mice odors on the physiological conditions of male mice. Aroma Research, 5(1), 38-43.
    • Koyama, S. 2002 The history of street performances using birds. The Japanese Journal of the History of Biology, 69, 108-109?
    • Koyama, S. 2002 The history of tricks using varied tits and images of animals in Japan. Japanese Journal of Livestock Management, 37(3), 124-128.
    • Koyama, S. 2001 Tricks using varied tits. Heredity, 55(1), p.1 (cover photos), 10-12.
    • Koyama, S. 2000 Influences of social status on animals – influences on sperm activity. Heredity, 54(5), 45-50.

    Awards

    • 2014 Nominee for Leading Light Award (“You Inspire Us”) for women of achievement in science, education and technology, Woman & Hi-Tech

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