The Ryan White Center for Pediatric Infectious Diseases and Global Health

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The Ryan White Center for Pediatric Infectious Diseases and Global Health at Indiana University School of Medicine is improving the health of children in Indiana and worldwide through the reduction and prevention of infection. With a research focus on malaria and HIV, infections that represent the leading causes of death and disability in children worldwide, faculty physicians at this center are recognized nationally for their work in global health.

Malaria Research

Malaria research at the Ryan White Center for Pediatric Infectious Diseases and Global Health focuses on why children develop severe malaria and the neurodevelopment consequences of severe malaria. Investigators are exploring the risks of malaria in children with sickle cell disease and the effects of changing transmission on malaria immunity.

Andrea Conroy Lab

Andrea Conroy, PhD, has two main areas of focus. First, she is interested in understanding how malaria in pregnancy alters the expression of proteins important for regulating placental blood vessel development and fetal growth. Second, she is evaluating the long-term implications of acute kidney injury on clinical recovery from severe malaria.

Dibyadyuti Datta Lab

The Dibyadyuti Datta, PhD lab focuses on both her research interests and experience that have been geared towards a better understanding of parasites biology at a molecular and biochemical level, with a specific focus on developing tools to fight the infection within communities.

Chandy John Lab

The Chandy John lab research focuses on the pathogenesis, immunology, and epidemiology of malaria, including the neurodevelopmental complications of malaria, and on prevention of infections, including malaria, in children with sickle cell disease.

Nathan Schmidt Lab

Nathan Schmidt, PhD, has research that is focused on defining the factors that impact malaria pathogenesis. One of the observations made by his lab was that the composition of bacteria residing within the intestinal tract can profoundly impact the severity of malaria. The influence of gut microbiota on malaria remains a central focus of his research.

Tuan Tran Lab

Tuan Tran, MD, PhD, studies both naturally acquired and vaccine-induced immunity to malaria using systems biology approaches. More specifically, his lab interrogates the immune system by applying multi-omic technologies to samples obtained from well-defined cohort studies of malaria-exposed individuals.

HIV Research

HIV research at IU School of Medicine’s Ryan White Center for Pediatric Infectious Diseases and Global Health focuses on adherence to HIV medications, stigma in HIV, disclosure of HIV status to children, evaluation and treatment of HIV in adolescents, and neurodevelopmental impairment in infants exposed to HIV.

Leslie Enane

Leslie Enane, MD, has research that focuses on global child health with an interest in HIV and TB care for children and adolescents. Her recent work has looked at barriers and facilitators to adolescent retention in HIV care.

Megan McHenry

Megan McHenry, MD, has cross-cultural research that focuses on global child health with a particular interest in neurodevelopment in children born to HIV-infected mothers and implementation science.

Alka Khaitan

Alka Khaitan, MD, has research that involves pediatric HIV, T-cell immunology, and global child health. Her work contributes to the understanding of severe and lasting immune disruptions associated with HIV disease progression in children despite successful antiretroviral treatment.