Otolaryngology—Head and Neck Surgery

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Research

Research

Researchers at the IU School of Medicine Department of Otolaryngology—Head and Neck Surgery contribute regularly to the creation of new knowledge, understanding and treatments surrounding diseases of the ear, nose and throat. Faculty members in this department study various challenges in this area of medicine, such as understanding how hearing loss affects a child’s developing brain, or how cachexia or unintentional weight loss affects cancer patients.

An area of research affecting both adults and children, otolaryngology provides wide and varied research interests. Scientists in this department are currently researching regenerative medicine, cancer cachexia, cerebrospinal fluid (CSF) leaks, inner ear disorders, neurofibromatosis, pediatric airway abnormalities, pediatric cochlear implants, and peripheral nerve regeneration.

Department researchers are employing innovative methods, such as using stem cells to create 3D organoids containing functional inner ear hair cells to better understand the common pathways that lead to hair cell degeneration and potentially find ways to prevent degeneration and hearing loss in the future.

Otolaryngology Research Facilities

The 3D Stem Cell Biology Research Group discovered a three-dimensional (3D) culture method for deriving mini inner ear organs and is using this process to explore normal embryonic development and model congenital/progressive hearing disorders to produce new regenerative therapies for profound hearing loss.

The DeVault Otologic Research Lab carries out basic and clinical research for the Department of Otolaryngology—Head and Neck Surgery at IU School of Medicine. The DeVault Lab research team investigates the impact of executive function on children with cochlear implants and related issues.