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Research by faculty within the Department of Microbiology and Immunology at IU School of Medicine centers on microbial pathogenesis, immunology, hematopoiesis, cancer biology and gene therapy. Current pathogenesis research focuses on Borrelia burgdorferi, Chlamydia trachomatis, Coxiella burnetii, Escherichia coli, Haemophilus ducreyi, Hepatitis B, Hepatitis C, HIV-1, Human Papillomavirus Virus, Leptospira interrogans, Toxoplasma gondii and malaria. A major effort is on developing experimental therapeutics for these pathogens.
The department has a strong emphasis in immunology. Ongoing studies include investigation of allergic and inflammatory diseases, immune signaling pathways and lymphocyte differentiation, immune evasion by viruses and tumors, autoimmune disease, innate and adaptive immunity, antigen presentation and B cell responses.
The department’s research on stem cells, hematopoiesis, transplantation and hematological malignancies is among the best in the United States. Among 97 medical schools nationwide, the department is ranked 28th in NIH funding with an annual research budget of approximately 8.5 million dollars.