Edward F. Srour, PhD, MS
Robert J. and Annie S. Rohn Professor Emeritus of Leukemia Research
Phone
(317) 274-0343
Address
Joseph E. Walther Hall, Room C312
980 W. Walnut St.
Indianapolis , IN 46202
980 W. Walnut St.
Indianapolis , IN 46202
Titles & Appointments
- Robert J. and Annie S. Rohn Professor Emeritus of Leukemia Research
- Professor Emeritus of Medicine
- Professor Emeritus of Pediatrics
- Professor Emeritus of Microbiology & Immunology
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Education1988 FEL Postdoctoral Fellowship, Indiana University, Indianapolis, IN1986 PhD University of Illinois1981 MS American University of Beirut1979 BS American University of Beirut
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ResearchHuman stem and progenitor cell biology in general and the possible use of purified preparations of these cells in transplantation. In addition, my laboratory is also pursuing mechanisms which would allow for ex vivo expansion of stem cells and their utilization as vehicles for gene therapy.
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PublicationsMitigating oxygen stress enhances aged mouse hematopoietic stem cell numbers and function.
Capitano ML; Mohamad SF; Cooper S; Guo B; Huang X; Gunawan AM; Sampson C; Ropa J; Srour EF; Orschell CM; Broxmeyer HE; The Journal of clinical investigation 2021 Jan 4Leptin receptor, a surface marker for a subset of highly engrafting long-term functional hematopoietic stem cells.
Trinh T; Ropa J; Aljoufi A; Cooper S; Sinn A; Srour EF; Broxmeyer HE; Leukemia 2020 Nov 7Megakaryocytes promote osteoclastogenesis in aging.
Kanagasabapathy D; Blosser RJ; Maupin KA; Hong JM; Alvarez M; Ghosh J; Mohamad SF; Aguilar-Perez A; Srour EF; Kacena MA; Bruzzaniti A; Aging 2020 Jul 7Aging negatively impacts the ability of megakaryocytes to stimulate osteoblast proliferation and bone mass.
Maupin KA; Himes ER; Plett AP; Chua HL; Singh P; Ghosh J; Mohamad SF; Abeysekera I; Fisher A; Sampson C; Hong JM; Childress P; Alvarez M; Srour EF; Bruzzaniti A; Pelus LM; Orschell CM; Kacena MA; Bone 2019 Jul 9CD166 Engagement Augments Mouse and Human Hematopoietic Progenitor Function via Activation of Stemness and Cell Cycle Pathways.
Zhang J; Ghosh J; Mohamad SF; Zhang C; Huang X; Capitano ML; Gunawan AM; Cooper S; Guo B; Cai Q; Broxmeyer HE; Srour EF; Stem cells (Dayton, Ohio) 2019 Aug 14Isolation and Identification of Murine Bone Marrow-Derived Macrophages and Osteomacs from Neonatal and Adult Mice.
Ghosh J; Mohamad SF; Srour EF; Methods in molecular biology (Clifton, N.J.) 2019Megakaryocyte and Osteoblast Interactions Modulate Bone Mass and Hematopoiesis.
Alvarez MB; Xu L; Childress PJ; Maupin KA; Mohamad SF; Chitteti BR; Himes E; Olivos DJ 3rd; Cheng YH; Conway SJ; Srour EF; Kacena MA; Stem cells and development 2018 May 15Absence of Cardiomyocyte Differentiation Following Transplantation of Adult Cardiac-Resident Sca-1<sup>+</sup> Cells Into Infarcted Mouse Hearts.
Soonpaa MH; Lafontant PJ; Reuter S; Scherschel JA; Srour EF; Zaruba MM; Rubart-von der Lohe M; Field LJ; Circulation 2018 Dec 18Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.
Micanovic R; Khan S; Janosevic D; Lee ME; Hato T; Srour EF; Winfree S; Ghosh J; Tong Y; Rice SE; Dagher PC; Wu XR; El-Achkar TM; Journal of the American Society of Nephrology : JASN 2017 Nov 27Individualized Breast Cancer Characterization through Single-Cell Analysis of Tumor and Adjacent Normal Cells.
Anjanappa M; Cardoso A; Cheng L; Mohamad S; Gunawan A; Rice S; Dong Y; Li L; Sandusky GE; Srour EF; Nakshatri H; Cancer research 2017 Mar 1p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation.
Hinge A; Xu J; Javier J; Mose E; Kumar S; Kapur R; Srour EF; Malik P; Aronow BJ; Filippi MD; Nature communications 2017 Feb 8Osteomacs interact with megakaryocytes and osteoblasts to regulate murine hematopoietic stem cell function.
Mohamad SF; Xu L; Ghosh J; Childress PJ; Abeysekera I; Himes ER; Wu H; Alvarez MB; Davis KM; Aguilar-Perez A; Hong JM; Bruzzaniti A; Kacena MA; Srour EF; Blood advances 2017 Dec 5Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow.
Clinkenbeard EL; Hanudel MR; Stayrook KR; Appaiah HN; Farrow EG; Cass TA; Summers LJ; Ip CS; Hum JM; Thomas JC; Ivan M; Richine BM; Chan RJ; Clemens TL; Schipani E; Sabbagh Y; Xu L; Srour EF; Alvarez MB; Kacena MA; Salusky IB; Ganz T; Nemeth E; White KE; Haematologica 2017 Aug 17Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype.
Olivos DJ 3rd; Alvarez M; Cheng YH; Hooker RA; Ciovacco WA; Bethel M; McGough H; Yim C; Chitteti BR; Eleniste PP; Horowitz MC; Srour EF; Bruzzaniti A; Fuchs RK; Kacena MA; Journal of cellular biochemistry 2017 Apr 18Cell Adhesion Molecule CD166 Drives Malignant Progression and Osteolytic Disease in Multiple Myeloma.
Xu L; Mohammad KS; Wu H; Crean C; Poteat B; Cheng Y; Cardoso AA; Machal C; Hanenberg H; Abonour R; Kacena MA; Chirgwin J; Suvannasankha A; Srour EF; Cancer research 2016 Sep 7Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators.
Silberstein L; Goncalves KA; Kharchenko PV; Turcotte R; Kfoury Y; Mercier F; Baryawno N; Severe N; Bachand J; Spencer JA; Papazian A; Lee D; Chitteti BR; Srour EF; Hoggatt J; Tate T; Lo Celso C; Ono N; Nutt S; Heino J; Sipilä K; Shioda T; Osawa M; Lin CP; Hu GF; Scadden DT; Cell stem cell 2016 Aug 11C-Mpl Is Expressed on Osteoblasts and Osteoclasts and Is Important in Regulating Skeletal Homeostasis.
Meijome TE; Baughman JT; Hooker RA; Cheng YH; Ciovacco WA; Balamohan SM; Srinivasan TL; Chitteti BR; Eleniste PP; Horowitz MC; Srour EF; Bruzzaniti A; Fuchs RK; Kacena MA; Journal of cellular biochemistry 2015 Oct 6Ames hypopituitary dwarf mice demonstrate imbalanced myelopoiesis between bone marrow and spleen.
Capitano ML; Chitteti BR; Cooper S; Srour EF; Bartke A; Broxmeyer HE; Blood cells, molecules & diseases 2015 Mar 28Activated leukocyte cell adhesion molecule (ALCAM or CD166) modulates bone phenotype and hematopoiesis.
Hooker RA; Chitteti BR; Egan PH; Cheng YH; Himes ER; Meijome T; Srour EF; Fuchs RK; Kacena MA; Journal of musculoskeletal & neuronal interactions 2015 MarSignaling pathways involved in megakaryocyte-mediated proliferation of osteoblast lineage cells.
Cheng YH; Streicher DA; Waning DL; Chitteti BR; Gerard-O'Riley R; Horowitz MC; Bidwell JP; Pavalko FM; Srour EF; Mayo LD; Kacena MA; Journal of cellular physiology 2015 MarEnhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock.
Mantel CR; O'Leary HA; Chitteti BR; Huang X; Cooper S; Hangoc G; Brustovetsky N; Srour EF; Lee MR; Messina-Graham S; Haas DM; Falah N; Kapur R; Pelus LM; Bardeesy N; Fitamant J; Ivan M; Kim KS; Broxmeyer HE; Cell 2015 Jun 11Modulation of hematopoietic progenitor cell fate in vitro by varying collagen oligomer matrix stiffness in the presence or absence of osteoblasts.
Chitteti BR; Kacena MA; Voytik-Harbin SL; Srour EF; Journal of immunological methods 2015 Jul 6Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.
Micanovic R; Chitteti BR; Dagher PC; Srour EF; Khan S; Hato T; Lyle A; Tong Y; Wu XR; El-Achkar TM; Journal of the American Society of Nephrology : JASN 2015 Jan 2A Novel Role for Thrombopoietin in Regulating Osteoclast Development in Humans and Mice.
Bethel M; Barnes CL; Taylor AF; Cheng YH; Chitteti BR; Horowitz MC; Bruzzaniti A; Srour EF; Kacena MA; Journal of cellular physiology 2015 Feb 5Human Adipose-Derived Stem Cells Ameliorate Cigarette Smoke-Induced Murine Myelosuppression via Secretion of TSG-6.
Xie J; Broxmeyer HE; Feng D; Schweitzer KS; Yi R; Cook TG; Chitteti BR; Barwinska D; Traktuev DO; Van Demark MJ; Justice MJ; Ou X; Srour EF; Prockop DJ; Petrache I; March KL; Stem cells (Dayton, Ohio) 2015 FebExpansion of prostate epithelial progenitor cells after inflammation of the mouse prostate.
Wang L; Zoetemelk M; Chitteti BR; Ratliff TL; Myers JD; Srour EF; Broxmeyer H; Jerde TJ; American journal of physiology. Renal physiology 2015 Apr 29Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-?B-dependent manner.
Wang L; Zhang H; Rodriguez S; Cao L; Parish J; Mumaw C; Zollman A; Kamoka MM; Mu J; Chen DZ; Srour EF; Chitteti BR; HogenEsch H; Tu X; Bellido TM; Boswell HS; Manshouri T; Verstovsek S; Yoder MC; Kapur R; Cardoso AA; Carlesso N; Cell stem cell 2014 Jul 3CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche.
Chitteti BR; Kobayashi M; Cheng Y; Zhang H; Poteat BA; Broxmeyer HE; Pelus LM; Hanenberg H; Zollman A; Kamocka MM; Carlesso N; Cardoso AA; Kacena MA; Srour EF; Blood 2014 Apr 16Cell cycle measurement of mouse hematopoietic stem/progenitor cells.
Chitteti BR; Srour EF; Methods in molecular biology (Clifton, N.J.) 2014Differential stem- and progenitor-cell trafficking by prostaglandin E2.
Hoggatt J; Mohammad KS; Singh P; Hoggatt AF; Chitteti BR; Speth JM; Hu P; Poteat BA; Stilger KN; Ferraro F; Silberstein L; Wong FK; Farag SS; Czader M; Milne GL; Breyer RM; Serezani CH; Scadden DT; Guise TA; Srour EF; Pelus LM; Nature 2013 Mar 13The changing balance between osteoblastogenesis and adipogenesis in aging and its impact on hematopoiesis.
Bethel M; Chitteti BR; Srour EF; Kacena MA; Current osteoporosis reports 2013 JunPyk2 regulates megakaryocyte-induced increases in osteoblast number and bone formation.
Cheng YH; Hooker RA; Nguyen K; Gerard-O'Riley R; Waning DL; Chitteti BR; Meijome TE; Chua HL; Plett AP; Orschell CM; Srour EF; Mayo LD; Pavalko FM; Bruzzaniti A; Kacena MA; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 JunCD166 and regulation of hematopoiesis.
Chitteti BR; Bethel M; Kacena MA; Srour EF; Current opinion in hematology 2013 JulHierarchical organization of osteoblasts reveals the significant role of CD166 in hematopoietic stem cell maintenance and function.
Chitteti BR; Cheng YH; Kacena MA; Srour EF; Bone 2013 Jan 28In vitro construction of 2D and 3D simulations of the murine hematopoietic niche.
Chitteti BR; Bethel M; Voytik-Harbin SL; Kacena MA; Srour EF; Methods in molecular biology (Clifton, N.J.) 2013Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis.
Broxmeyer HE; Hoggatt J; O'Leary HA; Mantel C; Chitteti BR; Cooper S; Messina-Graham S; Hangoc G; Farag S; Rohrabaugh SL; Ou X; Speth J; Pelus LM; Srour EF; Campbell TB; Nature medicine 2012 Nov 18Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors.
Broxmeyer HE; Srour EF; Cooper S; Wallace CT; Hangoc G; Youn BS; Blood cells, molecules & diseases 2011 Oct 7Regulation of murine hematopoietic stem cell quiescence by Dmtf1.
Kobayashi M; Srour EF; Blood 2011 Oct 28Impact of maturational status on the ability of osteoblasts to enhance the hematopoietic function of stem and progenitor cells.
Cheng YH; Chitteti BR; Streicher DA; Morgan JA; Rodriguez-Rodriguez S; Carlesso N; Srour EF; Kacena MA; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011 MayGenomic and proteomic analysis of the impact of mitotic quiescence on the engraftment of human CD34+ cells.
Chitteti BR; Liu Y; Srour EF; PloS one 2011 Mar 7Hematopoietic cell regulation of osteoblast proliferation and differentiation.
Bethel M; Srour EF; Kacena MA; Current osteoporosis reports 2011 JunThe SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs.
Rodriguez S; Wang L; Mumaw C; Srour EF; Lo Celso C; Nakayama K; Carlesso N; Blood 2011 Apr 18Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice.
Xue X; Pech NK; Shelley WC; Srour EF; Yoder MC; Dinauer MC; Blood 2010 Sep 2Application of polychromatic flow cytometry to identify novel subsets of circulating cells with angiogenic potential.
Estes ML; Mund JA; Mead LE; Prater DN; Cai S; Wang H; Pollok KE; Murphy MP; An CS; Srour EF; Ingram DA Jr; Case J; Cytometry. Part A : the journal of the International Society for Analytical Cytology 2010 SepOsteoblast lineage cells expressing high levels of Runx2 enhance hematopoietic progenitor cell proliferation and function.
Chitteti BR; Cheng YH; Streicher DA; Rodriguez-Rodriguez S; Carlesso N; Srour EF; Kacena MA; Journal of cellular biochemistry 2010 Oct 1Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function.
Chitteti BR; Cheng YH; Poteat B; Rodriguez-Rodriguez S; Goebel WS; Carlesso N; Kacena MA; Srour EF; Blood 2010 Feb 12CCR7 alters hematopoietic potential.
Srour EF; Blood 2010 Dec 9SLUG/SNAI2 and tumor necrosis factor generate breast cells with CD44+/CD24- phenotype.
Bhat-Nakshatri P; Appaiah H; Ballas C; Pick-Franke P; Goulet R Jr; Badve S; Srour EF; Nakshatri H; BMC cancer 2010 Aug 6Estradiol-regulated microRNAs control estradiol response in breast cancer cells.
Bhat-Nakshatri P; Wang G; Collins NR; Thomson MJ; Geistlinger TR; Carroll JS; Brown M; Hammond S; Srour EF; Liu Y; Nakshatri H; Nucleic acids research 2009 Jun 14Breast cancer stem cells and intrinsic subtypes: controversies rage on.
Nakshatri H; Srour EF; Badve S; Current stem cell research & therapy 2009 JanThe frequency of proliferative stromal cells in adipose tissue varies between inbred mouse strains.
Mo J; Srour E; Rosen E; Journal of stem cells & regenerative medicine 2009 Apr 8AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice.
Pulliam AC; Hobson MJ; Ciccone SL; Li Y; Chen S; Srour EF; Yang FC; Broxmeyer HE; Clapp DW; Experimental hematology 2008 May 20Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34(+) NOD/SCID-repopulating cells.
Liu Y; Hangoc G; Campbell TB; Goodman M; Tao W; Pollok K; Srour EF; Broxmeyer HE; Experimental hematology 2008 AugAdult bone marrow-derived cells do not acquire functional attributes of cardiomyocytes when transplanted into peri-infarct myocardium.
Scherschel JA; Soonpaa MH; Srour EF; Field LJ; Rubart M; Molecular therapy : the journal of the American Society of Gene Therapy 2008 Apr 22In vitro clonal analysis of murine pluripotent stem cells isolated from skeletal muscle and adipose stromal cells.
Case J; Horvath TL; Ballas CB; March KL; Srour EF; Experimental hematology 2007 Nov 26Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer.
Srirangam A; Mitra R; Wang M; Gorski JC; Badve S; Baldridge L; Hamilton J; Kishimoto H; Hawes J; Li L; Orschell CM; Srour EF; Blum JS; Donner D; Sledge GW; Nakshatri H; Potter DA; Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Mar 15Skeletal muscle-derived progenitor cells exhibit neural competence.
Kondo T; Case J; Srour EF; Hashino E; Neuroreport 2006 Jan 23Negative regulation of MHC class II gene expression by CXCR4.
Sheridan C; Sadaria M; Bhat-Nakshatri P; Goulet R Jr; Edenberg HJ; McCarthy BP; Chang CH; Srour EF; Nakshatri H; Experimental hematology 2006 AugClonal multilineage differentiation of murine common pluripotent stem cells isolated from skeletal muscle and adipose stromal cells.
Case J; Horvath TL; Howell JC; Yoder MC; March KL; Srour EF; Annals of the New York Academy of Sciences 2005 JunRapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist.
Broxmeyer HE; Orschell CM; Clapp DW; Hangoc G; Cooper S; Plett PA; Liles WC; Li X; Graham-Evans B; Campbell TB; Calandra G; Bridger G; Dale DC; Srour EF; The Journal of experimental medicine 2005 Apr 18
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