Brian Walker, PhD
Daniel and Lori Efroymson Professor of Oncology
Email
bw75@iu.edu
Address
Joseph E. Walther Hall
980 W. Walnut St., C310
Indianapolis, IN 46202-0000
980 W. Walnut St., C310
Indianapolis, IN 46202-0000
Titles & Appointments
- Daniel and Lori Efroymson Professor of Oncology
- Professor of Medicine
- Professor of Medical & Molecular Genetics
- Adjunct Professor, BioHealth Informatics
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Education2000 PhD University of London1996 BSC University of Edinburgh
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Research
Genomics and epigenetics of multiple myeloma (MM) and related plasma cell dyscrasias.
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PublicationsAlternative splicing in multiple myeloma is associated with the non-homologous end joining pathway.
Liu E; Becker N; Sudha P; Dong C; Liu Y; Keats J; Morgan G; Walker BA; Blood cancer journal 2023 Jan 20Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma.
Ansari-Pour N; Samur M; Flynt E; Gooding S; Towfic F; Stong N; Estevez MO; Mavrommatis K; Walker B; Morgan G; Munshi N; Avet-Loiseau H; Thakurta A; Blood 2023 Feb 9Structural variants shape the genomic landscape and clinical outcome of multiple myeloma.
Ashby C; Boyle EM; Bauer MA; Mikulasova A; Wardell CP; Williams L; Siegel A; Blaney P; Braunstein M; Kaminetsky D; Keats J; Maura F; Landgren O; Walker BA; Davies FE; Morgan GJ; Blood cancer journal 2022 May 30Chromosomal abnormalities in multiple myeloma.
Mikulasova A; Morgan GJ; Walker BA; Nature reviews. Disease primers 2022 Jun 16Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes.
Bustoros M; Anand S; Sklavenitis-Pistofidis R; Redd R; Boyle EM; Zhitomirsky B; Dunford AJ; Tai YT; Chavda SJ; Boehner C; Neuse CJ; Rahmat M; Dutta A; Casneuf T; Verona R; Kastritis E; Trippa L; Stewart C; Walker BA; Davies FE; Dimopoulos MA; Bergsagel PL; Yong K; Morgan GJ; Aguet F; Getz G; Ghobrial IM; Nature communications 2022 Jun 15Perspectives on the Risk-Stratified Treatment of Multiple Myeloma.
Davies FE; Pawlyn C; Usmani SZ; San-Miguel JF; Einsele H; Boyle EM; Corre J; Auclair D; Cho HJ; Lonial S; Sonneveld P; Stewart AK; Bergsagel PL; Kaiser MF; Weisel K; Keats JJ; Mikhael JR; Morgan KE; Ghobrial IM; Orlowski RZ; Landgren CO; Gay F; Caers J; Chng WJ; Chari A; Walker BA; Kumar SK; Costa LJ; Anderson KC; Morgan GJ; Blood cancer discovery 2022 Jul 6High-resolution simulations of chromatin folding at genomic rearrangements in malignant B cells provide mechanistic insights into proto-oncogene deregulation.
Rico D; Kent D; Karataraki N; Mikulasova A; Berlinguer-Palmini R; Walker BA; Javierre BM; Russell LJ; Brackley CA; Genome research 2022 Jul 21Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma.
Sudha P; Ahsan A; Ashby C; Kausar T; Khera A; Kazeroun MH; Hsu CC; Wang L; Fitzsimons E; Salminen O; Blaney P; Czader M; Williams J; Abu Zaid MI; Ansari-Pour N; Yong KL; van Rhee F; Pierceall WE; Morgan GJ; Flynt E; Gooding S; Abonour R; Ramasamy K; Thakurta A; Walker BA; Clinical cancer research : an official journal of the American Association for Cancer Research 2022 Jul 1Diagnostic Evidence GAuge of Single cells (DEGAS): a flexible deep transfer learning framework for prioritizing cells in relation to disease.
Johnson TS; Yu CY; Huang Z; Xu S; Wang T; Dong C; Shao W; Zaid MA; Huang X; Wang Y; Bartlett C; Zhang Y; Walker BA; Liu Y; Huang K; Zhang J; Genome medicine 2022 Feb 1The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states.
Rasche L; Schinke C; Maura F; Bauer MA; Ashby C; Deshpande S; Poos AM; Zangari M; Thanendrarajan S; Davies FE; Walker BA; Barlogie B; Landgren O; Morgan GJ; van Rhee F; Weinhold N; Nature communications 2022 Aug 3Molecular characterisation and clinical outcome of B-cell precursor acute lymphoblastic leukaemia with IG-MYC rearrangement.
Bomken S; Enshaei A; Schwalbe EC; Mikulasova A; Dai Y; Zaka M; Fung KT; Bashton M; Lim H; Jones L; Karataraki N; Winterman E; Ashby C; Attarbaschi A; Bertrand Y; Bradtke J; Buldini B; Burke GA; Cazzaniga G; Gohring G; De Groot-Kruseman HA; Haferlach C; Nigro LL; Parihar M; Plesa A; Seaford E; Sonneveld E; Strehl S; Van der Velden VH; Rand V; Hunger SP; Harrison CJ; Bacon CM; Van Delft FW; Loh ML; Moppett J; Vormoor J; Walker BA; Moorman AV; Russell LJ; Haematologica 2022 Apr 28Intron retention-induced neoantigen load correlates with unfavorable prognosis in multiple myeloma.
Dong C; Cesarano A; Bombaci G; Reiter JL; Yu CY; Wang Y; Jiang Z; Zaid MA; Huang K; Lu X; Walker BA; Perna F; Liu Y; Oncogene 2021 Sep 9Chromosomal 1q21 abnormalities in multiple myeloma: a review of translational, clinical research, and therapeutic strategies.
Bisht K; Walker B; Kumar SK; Spicka I; Moreau P; Martin T; Costa LJ; Richter J; Fukao T; Macé S; van de Velde H; Expert review of hematology 2021 Oct 8Impact of Etiological Cytogenetic Abnormalities on the Depth of Immunoparesis and Survival in Newly Diagnosed Multiple Myeloma.
Caro J; Cairns D; Menzies T; Boyle E; Pawlyn C; Cook G; Kaiser M; Walker BA; Owen R; Jackson GH; Morgan GJ; Heaney J; Drayson MT; Davies FE; Clinical lymphoma, myeloma & leukemia 2021 Oct 18Chromothripsis as a pathogenic driver of multiple myeloma.
Maura F; Boyle EM; Rustad EH; Ashby C; Kaminetzky D; Bruno B; Braunstein M; Bauer M; Blaney P; Wang Y; Ghamlouch H; Williams L; Stoeckle J; Davies FE; Walker BA; Maclachlan K; Diamond B; Landgren O; Morgan GJ; Seminars in cell & developmental biology 2021 May 3Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities.
Oben B; Froyen G; Maclachlan KH; Leongamornlert D; Abascal F; Zheng-Lin B; Yellapantula V; Derkach A; Geerdens E; Diamond BT; Arijs I; Maes B; Vanhees K; Hultcrantz M; Manasanch EE; Kazandjian D; Lesokhin A; Dogan A; Zhang Y; Mikulasova A; Walker B; Morgan G; Campbell PJ; Landgren O; Rummens JL; Bolli N; Maura F; Nature communications 2021 Mar 25Improving prognostic assignment in older adults with multiple myeloma using acquired genetic features, clonal hemopoiesis and telomere length.
Boyle EM; Williams L; Blaney P; Ashby C; Bauer M; Walker BA; Ghamlouch H; Choi J; Perrial E; Wang Y; Caro J; Stoeckle JH; Arbini A; Kaminetzky D; Braunstein M; Bruno B; Razzo B; Diamond B; Maclachlan K; Maura F; Landgren O; Litke R; Fegan CD; Keats J; Auclair D; Davies FE; Morgan GJ; Leukemia 2021 Jun 19High-risk transcriptional profiles in multiple myeloma are an acquired feature that can occur in any subtype and more frequently with each subsequent relapse.
Boyle EM; Rosenthal A; Wang Y; Farmer P; Rutherford M; Ashby C; Bauer M; Johnson SK; Wardell CP; Hoering A; Schinke C; Thanendrarajan S; Zangari M; Barlogie B; Davies FE; Walker BA; van Rhee F; Morgan GJ; British journal of haematology 2021 Jul 9The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma.
Boyle EM; Deshpande S; Tytarenko R; Ashby C; Wang Y; Bauer MA; Johnson SK; Wardell CP; Thanendrarajan S; Zangari M; Facon T; Dumontet C; Barlogie B; Arbini A; Rustad EH; Maura F; Landgren O; Zhan F; van Rhee F; Schinke C; Davies FE; Morgan GJ; Walker BA; Nature communications 2021 Jan 12Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers.
Mikulasova A; Kent D; Trevisan-Herraz M; Karataraki N; Fung KTM; Ashby C; Cieslak A; Yaccoby S; van Rhee F; Zangari M; Thanendrarajan S; Schinke C; Morgan GJ; Asnafi V; Spicuglia S; Brackley CA; Corcoran AE; Hambleton S; Walker BA; Rico D; Russell LJ; Genome research 2021 Dec 21Insights into high-risk multiple myeloma from an analysis of the role of PHF19 in cancer.
Ghamlouch H; Boyle EM; Blaney P; Wang Y; Choi J; Williams L; Bauer M; Auclair D; Bruno B; Walker BA; Davies FE; Morgan GJ; Journal of experimental & clinical cancer research : CR 2021 Dec 2Mutations in CRBN and other cereblon pathway genes are infrequently associated with acquired resistance to immunomodulatory drugs.
Jones JR; Barber A; Le Bihan YV; Weinhold N; Ashby C; Walker BA; Wardell CP; Wang H; Kaiser MF; Jackson GH; Davies FE; Chopra R; Morgan GJ; Pawlyn C; Leukemia 2021 Aug 9Plasma cells expression from smouldering myeloma to myeloma reveals the importance of the PRC2 complex, cell cycle progression, and the divergent evolutionary pathways within the different molecular subgroups.
Boyle EM; Rosenthal A; Ghamlouch H; Wang Y; Farmer P; Rutherford M; Ashby C; Bauer M; Johnson SK; Wardell CP; Wang Y; Hoering A; Schinke C; Thanendrarajan S; Zangari M; Barlogie B; Dhodapkar MV; Davies FE; Morgan GJ; van Rhee F; Walker BA; Leukemia 2021 Aug 7PHF19 inhibition as a therapeutic target in multiple myeloma.
Schinke CD; Bird JT; Qu P; Yaccoby S; Lyzogubov VV; Shelton R; Ling W; Boyle EM; Deshpande S; Byrum SD; Washam C; Mackintosh S; Stephens O; Thanendrarajan S; Zangari M; Shaughnessy J Jr; Zhan F; Barlogie B; van Rhee F; Walker BA; Current research in translational medicine 2021 Apr 22Cryopreservation Preserves Cell-Type Composition and Gene Expression Profiles in Bone Marrow Aspirates From Multiple Myeloma Patients.
Chen D; Abu Zaid MI; Reiter JL; Czader M; Wang L; McGuire P; Xuei X; Gao H; Huang K; Abonour R; Walker BA; Liu Y; Frontiers in genetics 2021 Apr 21Monitoring treatment response and disease progression in myeloma with circulating cell-free DNA.
Deshpande S; Tytarenko RG; Wang Y; Boyle EM; Ashby C; Schinke CD; Thanendrarajan S; Zangari M; Zhan F; Davies FE; Morgan GJ; van Rhee F; Walker BA; European journal of haematology 2020 Oct 26Bone marrow microenvironments that contribute to patient outcomes in newly diagnosed multiple myeloma: A cohort study of patients in the Total Therapy clinical trials.
Danziger SA; McConnell M; Gockley J; Young MH; Rosenthal A; Schmitz F; Reiss DJ; Farmer P; Alapat DV; Singh A; Ashby C; Bauer M; Ren Y; Smith K; Couto SS; van Rhee F; Davies F; Zangari M; Petty N; Orlowski RZ; Dhodapkar MV; Copeland WB; Fox B; Hoering A; Fitch A; Newhall K; Barlogie B; Trotter MWB; Hershberg RM; Walker BA; Dervan AP; Ratushny AV; Morgan GJ; PLoS medicine 2020 Nov 4Two Cases of Vancomycin-Resistant <i>Enterococcus faecium</i> Bacteremia With Development of Daptomycin-Resistant Phenotype and its Detection Using Oxford Nanopore Sequencing.
Udaondo Z; Jenjaroenpun P; Wongsurawat T; Meyers E; Anderson C; Lopez J; Mohan M; Tytarenko R; Walker B; Ussery D; Kothari A; Jun SR; Open forum infectious diseases 2020 May 23Genomic analysis of primary plasma cell leukemia reveals complex structural alterations and high-risk mutational patterns.
Schinke C; Boyle EM; Ashby C; Wang Y; Lyzogubov V; Wardell C; Qu P; Hoering A; Deshpande S; Ryan K; Thanendrarajan S; Mohan M; Yarlagadda N; Khan M; Choudhury SR; Zangari M; van Rhee F; Davies F; Barlogie B; Morgan G; Walker BA; Blood cancer journal 2020 Jun 19Long-term outcomes after autologous stem cell transplantation for multiple myeloma.
Nishimura KK; Barlogie B; van Rhee F; Zangari M; Walker BA; Rosenthal A; Schinke C; Thanendrarajan S; Davies FE; Hoering A; Morgan GJ; Blood advances 2020 Jan 28<i>BRAF</i> and <i>DIS3</i> Mutations Associate with Adverse Outcome in a Long-term Follow-up of Patients with Multiple Myeloma.
Boyle EM; Ashby C; Tytarenko RG; Deshpande S; Wang H; Wang Y; Rosenthal A; Sawyer J; Tian E; Flynt E; Hoering A; Johnson SK; Rutherford MW; Wardell CP; Bauer MA; Dumontet C; Facon T; Thanendrarajan S; Schinke CD; Zangari M; van Rhee F; Barlogie B; Cairns D; Jackson G; Thakurta A; Davies FE; Morgan GJ; Walker BA; Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Jan 27Differential RNA splicing as a potentially important driver mechanism in multiple myeloma.
Bauer MA; Ashby C; Wardell C; Boyle EM; Ortiz M; Flynt E; Thakurta A; Morgan G; Walker BA; Haematologica 2020 Feb 20Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease.
Mason MJ; Schinke C; Eng CLP; Towfic F; Gruber F; Dervan A; White BS; Pratapa A; Guan Y; Chen H; Cui Y; Li B; Yu T; Chaibub Neto E; Mavrommatis K; Ortiz M; Lyzogubov V; Bisht K; Dai HY; Schmitz F; Flynt E; Dan Rozelle; Danziger SA; Ratushny A; Multiple Myeloma DREAM Consortium.; Dalton WS; Goldschmidt H; Avet-Loiseau H; Samur M; Hayete B; Sonneveld P; Shain KH; Munshi N; Auclair D; Hose D; Morgan G; Trotter M; Bassett D; Goke J; Walker BA; Thakurta A; Guinney J; Leukemia 2020 Feb 14The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma.
Choudhury SR; Ashby C; Tytarenko R; Bauer M; Wang Y; Deshpande S; Den J; Schinke C; Zangari M; Thanendrarajan S; Davies FE; van Rhee F; Morgan GJ; Walker BA; Journal of hematology & oncology 2020 Aug 6TarPan: an easily adaptable targeted sequencing panel viewer for research and clinical use.
Ashby C; Rutherford M; Bauer MA; Peterson EA; Wang Y; Boyle EM; Wardell CP; Walker BA; BMC bioinformatics 2020 Apr 15A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations.
George SL; Izquierdo E; Campbell J; Koutroumanidou E; Proszek P; Jamal S; Hughes D; Yuan L; Marshall LV; Carceller F; Chisholm JC; Vaidya S; Mandeville H; Angelini P; Wasti A; Bexelius T; Thway K; Gatz SA; Clarke M; Al-Lazikani B; Barone G; Anderson J; Tweddle DA; Gonzalez D; Walker BA; Barton J; Depani S; Eze J; Ahmed SW; Moreno L; Pearson A; Shipley J; Jones C; Hargrave D; Jacques TS; Hubank M; Chesler L; European journal of cancer (Oxford, England : 1990) 2019 Sep 19Inactivating <i>NF1</i> Mutations Are Enriched in Advanced Breast Cancer and Contribute to Endocrine Therapy Resistance.
Pearson A; Proszek P; Pascual J; Fribbens C; Shamsher MK; Kingston B; O'Leary B; Herrera-Abreu MT; Cutts RJ; Garcia-Murillas I; Bye H; Walker BA; Gonzalez De Castro D; Yuan L; Jamal S; Hubank M; Lopez-Knowles E; Schuster EF; Dowsett M; Osin P; Nerurkar A; Parton M; Okines AFC; Johnston SRD; Ring A; Turner NC; Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Oct 7Microhomology-mediated end joining drives complex rearrangements and over expression of MYC and PVT1 in multiple myeloma.
Mikulasova A; Ashby C; Tytarenko RG; Qu P; Rosenthal A; Dent JA; Ryan KR; Bauer MA; Wardell CP; Hoering A; Mavrommatis K; Trotter M; Deshpande S; Yaccoby S; Tian E; Keats J; Auclair D; Jackson GH; Davies FE; Thakurta A; Morgan GJ; Walker BA; Haematologica 2019 Jun 20Daratumumab and dexamethasone is safe and effective for triple refractory myeloma patients: final results of the IFM 2014-04 (Etoile du Nord) trial.
Boyle EM; Leleu X; Petillon MO; Karlin L; Doyen C; Demarquette H; Royer B; Macro M; Moreau P; Fostier K; Marie-Lorraine C; Zarnitsky C; Perrot A; Herbaux C; Poulain S; Manier S; Beauvais D; Walker BA; Wardell CP; Vincent L; Frenzel L; Caillon H; Susanna S; Dejoie T; Avet-Loiseau H; Mohty M; Facon T; IFM2014-04 investigators.; British journal of haematology 2019 Jun 19Poor overall survival in hyperhaploid multiple myeloma is defined by double-hit bi-allelic inactivation of <i>TP53</i>.
Ashby C; Tytarenko RG; Wang Y; Weinhold N; Johnson SK; Bauer M; Wardell CP; Schinke C; Thanendrarajan S; Zangari M; van Rhee F; Davies FE; Sawyer JR; Morgan GJ; Walker BA; Oncotarget 2019 Jan 22Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients.
Jones JR; Weinhold N; Ashby C; Walker BA; Wardell C; Pawlyn C; Rasche L; Melchor L; Cairns DA; Gregory WM; Johnson D; Begum DB; Ellis S; Sherborne AL; Cook G; Kaiser MF; Drayson MT; Owen RG; Jackson GH; Davies FE; Greaves M; Morgan GJ; NCRI Haemato-Oncology CSG.; Haematologica 2019 Feb 7An acquired high-risk chromosome instability phenotype in multiple myeloma: Jumping 1q Syndrome.
Sawyer JR; Tian E; Walker BA; Wardell C; Lukacs JL; Sammartino G; Bailey C; Schinke CD; Thanendrarajan S; Davies FE; Morgan GJ; Barlogie B; Zangari M; van Rhee F; Blood cancer journal 2019 Aug 9Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes.
Went M; Kinnersley B; Sud A; Johnson DC; Weinhold N; Försti A; van Duin M; Orlando G; Mitchell JS; Kuiper R; Walker BA; Gregory WM; Hoffmann P; Jackson GH; Nöthen MM; da Silva Filho MI; Thomsen H; Broyl A; Davies FE; Thorsteinsdottir U; Hansson M; Kaiser M; Sonneveld P; Goldschmidt H; Stefansson K; Hemminki K; Nilsson B; Morgan GJ; Houlston RS; Human genomics 2019 Aug 20Draft Genome Sequences of 48 Vancomycin-Resistant Enterococcus faecium Strains Isolated from Inpatients with Bacteremia and Urinary Tract Infection.
Udaondo Z; Wongsurawat T; Jenjaroenpun P; Anderson C; Lopez J; Mohan M; Tytarenko R; Walker B; Nookaew I; Ussery D; Kothari A; Jun SR; Microbiology resource announcements 2019 Apr 11A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis.
Walker BA; Mavrommatis K; Wardell CP; Ashby TC; Bauer M; Davies F; Rosenthal A; Wang H; Qu P; Hoering A; Samur M; Towfic F; Ortiz M; Flynt E; Yu Z; Yang Z; Rozelle D; Obenauer J; Trotter M; Auclair D; Keats J; Bolli N; Fulciniti M; Szalat R; Moreau P; Durie B; Stewart AK; Goldschmidt H; Raab MS; Einsele H; Sonneveld P; San Miguel J; Lonial S; Jackson GH; Anderson KC; Avet-Loiseau H; Munshi N; Thakurta A; Morgan G; Leukemia 2018 Jul 2Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma.
Rasche L; Alapat D; Kumar M; Gershner G; McDonald J; Wardell CP; Samant R; Van Hemert R; Epstein J; Williams AF; Thanendrarajan S; Schinke C; Bauer M; Ashby C; Tytarenko RG; van Rhee F; Walker BA; Zangari M; Barlogie B; Davies FE; Morgan GJ; Weinhold N; Leukemia 2018 Dec 20 -
Professional OrganizationsRoyal College of Pathologists, UK
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