YOU ARE EXPLORING
Assistant Professor of Medical & Molecular Genetics
Dr. Chi Zhang focuses on computational modeling of cancer micro-environment including the level of hypoxia, oxidative stress, acidity and dysregulation of extracellular matrix as well as altered immune responses in cancer tissue by using large scale omics data. Dr. Chi Zhang is also interested in developing novel computation methods to integrate multiple tissue level and single cell omics data types to understand the mechanism of cancer initiation, progression, metastasis and cancer tumor tissue’s resistance to certain therapies. In addition, his research application also includes inference of intra-tumor heterogeneity and reprogrammed metabolism, and prediction of gain or loss of functions led by a certain mutation or collective effect of multiple mutations.
Titles & Appointments
- Adjunct Assistant Professor, School of Informatics and Computing
? Statistical and computational modelling of cancer initiation and progression, including energy metabolism reprogramming, interactions between cancer cells and microenvironment
? Intra-tumor heterogeneity and its relationship with cancer associated micro-environmental stress
? Prediction of gain or loss of function of certain mutations and interactive effect of multiple mutations
? Develop statistical deconvolution method to predict the alterations of immune and stroma cells in tissue based omics data.
? Develop novel computation methods to integrate multiple omics types to model the biological characteristics in progression of inflammatory diseases and cancer
? Single cell RNA-Seq data analysis
? Bi-clustering algorithm development
Desc: Graduate student excellence-in-research award (Five recipients every year. Awarded as the recipient in Life Sciences)