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Janaiah Kota

Janaiah Kota

Assistant Professor of Medical & Molecular Genetics

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Bio

Dr. Kota grew up in rural India helping his parents on the farm. Since his childhood, he has a passion for biology and applying that knowledge to improve human lives. To bring his dreams into reality, he earned his BS in Agriculture and PhD in Seed Science from Indian Agriculture Research Institute, New Delhi. His graduate research project was on genetic and biochemical aspects of seed dormancy to reduce pre & post-harvest crop losses. After his graduation, he moved to the US and spent about a year in plant sciences and switched his career path to biomedical sciences for exploring his long-term passion and commitment to understand fundamental aspects of human disease and developing novel therapies.

He joined Dr. Jerry Mendell's laboratory for post-doctoral training at the Center for Gene therapy, Nationwide Children’s Hospital, Columbus, Ohio and made outstanding contributions to translational gene therapy for neuromuscular diseases and basic cancer biology. His non-human primate work on AAV-follistatin muscle building strategy (Kota et al, 2009, Science Transnational Medicine) in combination with prior findings from Drs. Kaspar & Mendell's teams led to Phase I/II clinical trials in two muscular dystrophy patient populations. His second area of work in miRNA-cancer biology, in collaboration with Dr. Joshua Mandell (Kota et al., 2009 Cell), led him to his path of independent research.

Dr. Kota joined the Medical and Molecular Genetics faculty at the Indiana University School of Medicine with a major research focus on understanding the fundamental mechanistic role of miR-29 in pancreatic cancer tumor microenvironment. He is currently also a member of the IU Melvin and Bren Simon Cancer Center-Tumor Microenvironment and Pancreatic Cancer working groups and Associate Director of Molecular Testing at the Indiana University Vector Production Facility. He is an American Cancer Society Research Scholar.

Key Publications

Jones R K, Nabinger CS, Sangbin L, Sahu SS, Althrouse A, Saxena S, Johnosn SM,Chalasani N, Gawreih S, Kota J (2018). Lower Expression of Tumor MicroRNA-26a is Associated with Higher Recurrence in Patients with Hepatocellular Carcinoma Undergoing Surgical Treatment. Journal of Surgical Oncology. PMID: 30076741

Adelaiye-Ogala R, Damayanti N , Budka J, Ferris M, Arrington J,  Hsu C, Chintala S,  Orillion A,  Miles KM, Shen L, Elbanna M, Ciamporcero E,  Arisa S, Pettazzoni P, Draetta GF, Mukund Seshadri M, Radovich M, Kota J, Buck M, Keilhack H, McCarthy BP, Persohn SA, Territo PR , Zang Y, Irudayaraj J, Tao WA, Hollenhorst P  and Pili R (2017). EZH2 modifies sunitinib resistance in renal cell carcinoma by kinome reprogramming. Cancer Research. 77 (23):6651-66. PMID: 28978636

Kota J, Hancock J, Kwon JJ, Korc M (2017). Pancreatic Cancer: Stroma and its Current and Emerging Targeted Therapies. Cancer Lett. PMID:28093284

Quirin KA, Kwon JJ, Alioufi A, Factora T, Temm CJ, Jacobsen M, Sandusky GE, Shontz K, Chicoine LG, Clark KR, Mendell JT, Korc M, Kota J (2017). Safety and efficacy of AAV retrograde pancreatic ductal gene delivery in normal and pancreatic cancer mice. Molecular Therapy Methods & Clinical Development. PMCID: PMC5675991

Kwon JJ, Willy JA, Quirin KA, Wek RC, Korc M, Yin XM, and Kota J (2016). Novel role of miR-29 in pancreatic cancer autophagy and its therapeutic potential. Oncotarget. PMCID: PMC5342107

Surendran S, Jideonwo V, Merchun C, Ahn M, Murray J, Hou Y, Ryan J, Dunn K, Dai G, Kota J, Morral, N (2016). Gene targets of mouse miR-709: regulation of distinct pools. Scientific Reports 6:18958. PMCID: PMC4705522

Kwon JJ, Nabinger CS, Alluri KR, Vega Z, Sahu SS, Sater AZ, Yu Z, Gore A J, Nalepa G, Saxena R, Korc M, Kota J (2015). Pathophysiological role of microRNA-29 in pancreatic cancer stroma. Scientific Reports 5:11450. PMCID: PMC4476113

Mendell JR, Rodino-Klapac L, Sahenk Z,  Roush K, Bird L, Lowes LP,  Alfano L Gomez, AM,  Lewis S, Kota J, Malik V,  Shontz K, Flanigan KM, Kean JR, Allen HD, Shilling C,  Sazani P, Kaye EM (2013). Effect of Eteplirsen on Dystrophin and Walking in Duchenne's muscular dystrophy. Ann Neurol 2013; 74(5): 637-647. PMID:23907995

Rosales XQ, Malik V, Sneh A, Chen L, Lewis S, Kota J, Gastier-Foster JM, Astbury C, Pyatt R, Reshmi S, Rodino-Klapac LR, Clark KR, Mendell JR, Sahenk Z. (2013). Impaired regeneration in LGMD2A supported by increased PAX7-positive satellite cell content and muscle-specific microRNA dysregulation. Muscle & Nerve 47(5):731-739. PMCID: PMC3634894

Hsu SS*, Wang B*, Kota J*, Kutay H*, Costinean S*, Bai S*, Yu L, Perle LK, Chivukula RR, Clark KR, Mendell JR, Samson JT , Mendell JT and Ghoshal K. (2012). Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. Journal of Clinical Investigation 122(8):2871–2883. *co-first author. PMCID: PMC3408748

Mendell JR, Rodino-Klapac LR, Rosales XQ, Coley BD, Galloway G, Lewis S, Malik V, Shilling C, Byrne BJ, Conlon T, Campbell KJ, Bremer WG, Taylor LE, Flanigan KM, Gastier-Foster JM, Astbury C, Kota J, Sahenk Z, Walker CM, Clark KR. (2010). Sustained alpha-sarcoglycan gene expression after gene transfer in LGMD2D. Ann Neurol 2010; 68: 629-638. PMCID: PMC2970162

Malik V, Rodino-Klapac LR, Viollet L, Wall C, King W, Al-Dahhak R, Lewis S, Shilling CJ, Kota J, Serrano-Munuera C, Hayes J, Mahan JD, Campbell KJ, Banwell B, Dasouki M, Watts V, Sivakumar K, Bien-Willner R, Flanigan KM, Sahenk Z, Barohn RJ, Walker CM, Mendell JR. (2010). Gentamicin-induced read-through of stop codons in Duchenne muscular dystrophy. Ann Neurol 67:771-780. PMID 20517938

Kota J, Handy CR, Haidet A, Montgomery CL, Eagle A, Rodino-Klapac LR, Tucker D, Shilling CJ, Therlfall W, Walker CM, Weisrode SE, Janssen PML, Clark KR, Sahenk Z, Mendell JR, Kaspar BK. (2009). Follistatin gene delivery enhances muscle growth and strength nonhuman primates. Science Translational Medicine 1(6): 6ra15 PMCID: PMC2852878

Kota J, Chivukula RR, O’Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Clark KR, Mendell JR, Mendell JT. (2009). Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137(6):1005-1017* PMCID: PMC2722880

*Nature Medicine recognized this article as-Notable Advances/Key papers published in 2009

Panguluri SK, Kota J, Govil JN, Kumar PA, Sharma PC. (2006). AFLP fingerprinting in pigeon pea (Cajanus cajan (L.) Millsp.) and its wild relatives. Genetic Resources and Crop Evolution 53, 523-531

Kota J, Kant K, Dadlani M. (2006).  Efficacy of dormancy breaking methods in indica rice varieties. Seed Research 34 (1), 45-49

Kota J, Kant K, Sharma SP (2003).  Use of phenol colour test for characterization of rice (Oryza sativa L.) cultivars. Seed Research 31(2),141-147

Connect


jkota@iu.edu 


(317) 278-2105 


Medical & Molecular Genetics
975 W. Walnut Street, IB 244C
Indianapolis, IN 46202-5251


  

Titles & Appointments

  • Associate Director of Molecular Testing, Indiana Vector Production Facility
  • Member of the IU Simon Cancer Center, Tumor Microenvironment & Pancreatic Cancer Working Groups