Emergency Medicine

Translational Research

The IU School of Medicine Department of Emergency Medicine conducts translational research in two laboratories: the Kline Lab and Alves Lab. These two facilities investigate new ways to improve health care by translating bench research to the bedside of patients.

Kline Lab

Led by Jeff Kline, MD, this research facility includes 850 square feet of laboratory space in the Medical Science Building on the IU School of Medicine—Indianapolis campus. It connects via corridor to IU Health University Hospital, where investigators collect samples from patients, which are analyzed in this lab. The Kline Lab investigators work with several different organisms—ranging from an e coli expression vector used to make a mutant plasmin for dissolving blood clots to rats, pigs and humans with pulmonary embolism. The main therapeutic goals are to produce clot lysis while not increasing the bleeding risk and to protect the right ventricle from damage. The three rooms of this lab include a biochemistry/protein production and purification laboratory; a lab equipped to measure hemostasis, coagulation, NOx and cellular metabolism; and a rat surgery area, with dander abatement equipment.

Alves Lab

Led by Nathan Alves, PhD, this lab focuses on translational technologies, treatments and techniques in an interdisciplinary setting, as researchers apply engineering principles and designs to create translational technologies for clinical implementation. Located in the Medical Sciences Building on the IU School of Medicine—Indianapolis campus, the Alves Lab is 1350 square feet of laboratory space split across three rooms, each representing a diverse and state-of-the-art translational research center. This space includes a biomarker, biochemistry and small, dander-free molecule/protein purification room; an animal surgery/housing, exercise testing, echocardiography; and a Langendorff room.