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Thomas D. Hurley, PhD
Associate Dean for Graduate Education
Dr. Hurley received his PhD in Biochemistry from Indiana University in 1990 under the direction of Dr. William Bosron where his research focused on an analysis of structure and function of human alcohol dehydrogenases and how polymorphisms in these enzymes impact their ability to metabolize beverage ethanol. Dr. Hurley received post-doctoral training at the Johns Hopkins School of Medicine under Dr. Mario Amzel in the Biophysics and Biophysical Chemistry Department where he pursued training in the application of X-ray crystallography to understand enzyme structure and function. He joined the faculty within the Department of Biochemistry and Molecular Biology at Indiana University School of Medicine in 1992. His research areas include the application of X-ray crystallography, enzyme kinetics and small molecule drug discovery to enzyme targets that underlie particular disease states. Dr. Hurley has two broad areas of research interest. The first area focuses on the roles that different human aldehyde dehydrogenases play in cancer stem cells (tumor initiating cells) through the discovery and development of isoenzyme specific small molecule inhibitors. This work is in collaboration with investigators at the Northwestern University School of Medicine and with investigators at the University of Michigan. His second area of interest is in developing inhibitors for human glycogen synthase as a potential treatment for glycogen storages diseases where glycogen over-accumulation is the primary cause of disease.
Titles & Appointments
- Chancellor's Professor, IUPUI
- Professor of Biochemistry & Molecular Biology
The major focus of Dr. Hurley’s research lab is to understand, at the molecular level, the processes involved in the recognition and binding of molecules that are directed to the active sites of enzymes. The main approaches utilized in our laboratory are X-ray crystallography, inhibitor screening, detailed enzyme kinetics and mass spectrometry.