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X C. Dong, PhD
Associate Professor of Biochemistry & Molecular Biology
X. Charlie Dong, PhD, is an Associate Professor in the Department of Biochemistry and Molecular Biology and investigator of Indiana University Center of Diabetes and Metabolic Diseases. He is also a Showalter Scholar selected by the Showalter Trust Fund and IU School of Medicine. Prior to his appointment at Indiana University, he got his B.S. in Biology from Shandong Normal University, M.S. in Genetics from Chinese Academy of Sciences Institute of Genetics and Developmental Biology, and Ph.D. in Molecular and Cellular and Developmental Biology from the Ohio State University. He also received postdoctoral training in diabetes and metabolism from Joslin Diabetes Center and Children's Hospital Boston of Harvard Medical School. He was promoted to instructor in pediatrics at Harvard Medical School.
Diabetes and obesity have both reached epidemic proportions in the United States. It is becoming urgent to elucidate the pathological mechanisms of these health problems. Improper gene regulation by transcriptional and epigenetic factors critically involves in the pathogenesis of these metabolic diseases. Dr. Dong's laboratory investigates two key families of factors that are emerging as critical regulators in nutrient and energy homeostasis - FOXO transcription factors and nuclear sirtuins (SIRT1/6). FOXOs are key players in the downstream of insulin signaling and regulate glucose and lipid homeostasis. SIRT1 and SIRT6 are both NAD-dependent histone deacetylases and modulate chromatin stability and dynamics. We have characterized several crucial FOXO target genes including Nr0b2 (SHP), Nampt, Srebp2, Pcsk9, and Sesn3, in the regulation of glucose and lipid metabolism and insulin sensitivity. Our research goal is to utilize the state-of-the-art technologies including genomics, epigenomics, proteomics, metabolomics, high-resolution imaging, and genomic editing to elucidate molecular and pathophysiological mechanisms underlying diabetes, obesity, and fatty liver disease and develop therapeutics for these disorders.
Dr. Dong has served on multiple committees at IUPUI including the Institutional Biosafety Committee, Graduate Admission Committee, the Center for Diabetes and Metabolic Disease Executive Committee, and NIH study sections.