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A Multicenter, Open-Label, Randomized, Bupivacaine-Controlled Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Aged 0 to Less Than 6 ...
This Phase 1, multicenter, open-label, randomized, bupivacaine-controlled study is designed to evaluate the pharmacokinetics (PK) and safety of EXPAREL vs. bupivacaine HCl for postsurgical analgesia in pediatric subjects aged 0 ...
Cleopattra: Effects of Nnc6019-0001 Versus Placebo on Cardiovascular Outcomes in Participants with Transthyretin Amyloid Cardiomyopathy
This study will find out if a new medicine called NNC6019-0001 can help reduce the risk of heart-related death and illness in participants with a condition called transthyretin amyloid cardiomyopathy ...
Efficacy and Safety of Nnc0487-0111 Compared to Placebo on Morbidity and Mortality in People with Heart Failure with Preserved or Mildly Reduced Ejection Fraction ...
This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced ...
1011003020 1011003020 1011003020 Congenital Heart Surgeons' Society (CHSS) Studies in Congenital Heart Disease
The purpose of this study is to participate in a registry of patients with congenital heart disease. Patient data from the United States, Canada, and South America (whose institutions of ...
50% and with Either a Wide QRS Complex (>130 Ms) or with/Anticipated >40% Pacing Randomized Clinical Trial
Cardiac-resynchronization therapy (CRT) is a type of heart failure (HF) treatment that improves the way your heart works, improves your ability to exercise, reduces hospitalization, and lengthens your lifespan. CRT ...
1509977311 Pathogenetic Basis of Aortopathy and Aortic Valve Disease
The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by ...
1708709756 1708709756 1708709756 Genomic and Biomarker Studies in Pulmonary Hypertension
Pulmonary hypertension (PH) is an uncommon disease characterized by increased blood pressure in the pulmonary artery, which can lead to right heart failure and death. PH may be related to ...
A Phase 2, Randomized, Multicenter, Open-Label, Blinded-Endpoint Study to Evaluate the Safety of Regn7508 and Regn9933, Monoclonal Antibodies Against Fxi, Versus Apixaban in Participants with ...
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly. ...
Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults with Severe Hypertriglyceridemia at High Risk of Acute Pancreatitis
This study will evaluate the efficacy and safety of plozasiran in approximately 140 adult participants with severe hypertriglyceridemia (SHTG) and history of at least two prior acute pancreatitis (AP) events ...
A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Levosimendan in Pulmonary Hypertension Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction
The study will evaluate the efficacy and safety of chronic oral levosimendan compared with placebo in PH-HFpEF subjects. This subject population represents a large and growing group with no established ...