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A Multicenter, Open-Label, Randomized, Bupivacaine-Controlled Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Aged 0 to Less Than 6 ...
This Phase 1, multicenter, open-label, randomized, bupivacaine-controlled study is designed to evaluate the pharmacokinetics (PK) and safety of EXPAREL vs. bupivacaine HCl for postsurgical analgesia in pediatric subjects aged 0 ...
Cleopattra: Effects of Nnc6019-0001 Versus Placebo on Cardiovascular Outcomes in Participants with Transthyretin Amyloid Cardiomyopathy
This study will find out if a new medicine called NNC6019-0001 can help reduce the risk of heart-related death and illness in participants with a condition called transthyretin amyloid cardiomyopathy ...
1011003020 1011003020 1011003020 Congenital Heart Surgeons' Society (CHSS) Studies in Congenital Heart Disease
The purpose of this study is to participate in a registry of patients with congenital heart disease. Patient data from the United States, Canada, and South America (whose institutions of ...
50% and with Either a Wide QRS Complex (>130 Ms) or with/Anticipated >40% Pacing Randomized Clinical Trial
Cardiac-resynchronization therapy (CRT) is a type of heart failure (HF) treatment that improves the way your heart works, improves your ability to exercise, reduces hospitalization, and lengthens your lifespan. CRT ...
1509977311 Pathogenetic Basis of Aortopathy and Aortic Valve Disease
The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by ...
1708709756 1708709756 1708709756 Genomic and Biomarker Studies in Pulmonary Hypertension
Pulmonary hypertension (PH) is an uncommon disease characterized by increased blood pressure in the pulmonary artery, which can lead to right heart failure and death. PH may be related to ...
A Phase 3, Open-Label, Uncontrolled Single-Arm Study to Evaluate the Efficacy, Pharmacokinetics, and Safety of Avacopan in Combination with a Rituximab or a Cyclophosphamide-Containing Regimen ...
The rationale of this phase 3 study is to explore whether avacopan combined with a rituximab (RTX) or cyclophosphamide (CYC)-containing regimen is safe and effective in inducing and maintaining remission ...
A Phase 2, Randomized, Multicenter, Open-Label, Blinded-Endpoint Study to Evaluate the Safety of Regn7508 and Regn9933, Monoclonal Antibodies Against Fxi, Versus Apixaban in Participants with ...
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly. ...
Corticotrophin Releasing Factor 2 Agonist for the Treatment of Worsening Heart Failure (Whf)
This study assesses the effects of the investigational drug COR-1167 in subjects hospitalised due to worsening of heart failure (HF).THIS STUDY IS ENROLLING BY INVITATION ONLY
A Phase 2 Double-Blind Placebo-Controlled Single-Dose Study of Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of REGN7544, an NPR1 Antagonist Monoclonal Antibody, in Patients with Postural Orthostatic ...
This study is researching an experimental drug called REGN7544 (called "study drug"). The study is focused on participants with POTS.The aim of the study is to see how safe, tolerable, ...