Evaluation of Genetic Mutations in African American with Glaucoma Associated with Long Anterior Zonules (LAZ)

WM

Weiming Mao

Principal Investigator

Status: Enrolling By Invitation Ages: 18 Years - 100 Years Gender: All Genders Phase: N/A 2 Locations

Brief Description

What is the purpose of this study?

Long anterior zonules (LAZ) is the presence of the zonular fibers (a tissue that holds the lens in place) attaching to the anterior part of the lens. LAZ is a rare disease and is genetically associated with certain gene mutations.  It has been reported primarily in older African American women and is associated with glaucoma. The purpose of this study is to study the DNA mutations of the subjects.

THIS STUDY IS ENROLLING BY INVITATION ONLY -   Dr. Mohammadi will use his patient's health history and/or diagnosis to identify suitable subjects and enroll them at IU clinics. Patients will be approached during their clinical visit or will be contacted by phone about study participation.

Detailed Description

What will happen during the study?

The objective of this study is to determine the prevalence and disease-associated genotype in African American pigmentary glaucoma patients with LAZ. Our hypothesis is that there are a subset of gene mutations associated with African American pigmentary glaucoma patients with LAZ.

Up to 10ml blood samples will be collected from the subject’s arm.  Blood samples will collected and DNA will be extracted for sequencing. We will compare the results with published mutations/polymorphisms associated with LAZ.

Eligibility of study

Inclusion Criteria
Patients with LAZ

Exclusion Criteria
<18 yr old
Adults lacking consent capacity
Prisoners
Individuals admitted for inpatient or residential psychiatric treatment
Nonviable neonates or neonates of uncertain viability

Interested in participating?

Enrollment in IU School of Medicine clinical trials is managed through our All IN for Health program. Many studies only accept people who are part of an invited group. Visit allinforhealth.info to connect with the study team, or contact your doctor to see if you are eligible.