Binge & High-Intensity Drinking

MP

Martin Plawecki, MD, PhD

Principal Investigator

Status: Enrolling By Invitation Ages: 21 Years - 35 Years Gender: All Genders Phase: N/A 1 Locations

Brief Description

The purpose of this study is to examine the relationships between drinking behaviors in both  normal life and in our laboratory. Results from this study may help us better understand the relationships between drinking behavior, family drinking history and brain function.
 

Detailed Description

Participants will complete a screening visit (unless it was already completed as part of another related study), two (2) alcohol infusion sessions over 1-2 weeks, followed by an Functional Magnetic Resonance Imaging (fMRI) session a week or two later. 
 

Eligibility of study

Inclusion Criteria:
  •  
  • Overtly healthy men and women aged 21 – 35
  • At least 3 or 4 drinks on an occasion for women and men, respectively over the last month, unless determined by PI that drinking history meets study objectives
  • Right-handed
Exclusion Criteria:
  •  
  • MRI Contraindications
  • Pregnant or breast-feeding women
  • Desire for AUD treatment or court ordered to not drink alcohol
  • Medical or non-AUD psychiatric disorders, such as seizure disorder, schizophrenia, or other conditions that may influence study outcome or participant safety
  • Positive urine drug screen for amphetamines/ methamphetamines, barbiturates, benzodiazepines, cocaine, opiates, or phencyclidine and/or evidence of intoxication
  • Medications or dosage changes (past 30 days) that could influence data/participant safety (e.g., antidepressants, antipsychotics, benzodiazepines, etc.) as determined by PIs
  • Current/history of neurological disease of cerebral origin, head injury with > 20 min loss of consciousness, or medical treatment impacting MRI data integrity or representativeness
  • Positive BrAC reading precluding visit completion
  • Actively suicidal (any suicide attempts within the past year or any current suicidal intent, including a plan) or are at serious suicidal risk, by clinical evaluation by the PIs
  • Left-handed or ambidextrous
  • Inability to understand and comply with study instructions in English
  • Any reason for which the PI determines that inclusion in the study would compromise the safety of the subject or integrity of the study.
 

Interested in participating?

Enrollment in IU School of Medicine clinical trials is managed through our All IN for Health program. Many studies only accept people who are part of an invited group. Visit allinforhealth.info to connect with the study team, or contact your doctor to see if you are eligible.