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Roman Dziarski

Roman Dziarski, PhD

Professor of Microbiology & Immunology

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Bio

Selected Publications

Liu C, Gelius E, Liu G, Steiner H, Dziarski R. 2000. Mammalian peptidoglycan recognition protein binds peptidoglycan with high affinity, is expressed in neutrophils, and inhibits bacterial growth. J. Biol. Chem.  275: 24490-24499, PMID: 10827080.   

Liu C, Xu Z, Gupta D, Dziarski R. 2001. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. J. Biol. Chem. 276: 34686-34694 (featured on the cover), PMID: 11461926.

Dziarski R, Platt KA, Gelius E, Steiner H, Gupta D. 2003. Defect in neutrophil killing and increased susceptibility to infection with non-pathogenic Gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)-deficient mice. Blood 102: 689-697 (featured in a Blood editorial), PMID: 12649138.

Wang Z-M, Li X, Cocklin RR, Wang M, Wang M, Fukase K, Inamura S, Kusumoto K, Gupta D, Dziarski R.  2003. Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase. J. Biol. Chem. 278: 49044-49052, PMID: 14506276.

Zhang Y, van der Fits L, Voerman JS, Melief M-J, Laman JD, Wang M, Wang H, Wang M, Li X, Walls CD, Gupta D, Dziarski R. 2005. Identification of serum N-acetylmuramoyl-L-alanine amidase as liver peptidoglycan recognition protein 2. Biochim. Biophys. Acta – Proteins and Proteomics 1752:34-46, PMID: 16054449.

Wang H, Gupta D, Li X, Dziarski R. 2005. Peptidoglycan recognition protein 2 (N-acetylmuramoyl-L-ala amidase) is induced in keratinocytes by bacteria through p38 kinase pathway. Infect. Immun. 73:7216-7225, PMID: 16239516.

Lu X, Wang M, Qi J, Wang H, Li X, Gupta D, Dziarski R.  2006. Peptidoglycan recognition proteins are a new class of human bactericidal proteins. J. Biol. Chem. 281: 5895-5907, PMID: 16354652.

Dziarski R, Gupta D. 2006. The peptidoglycan recognition proteins (PGRPs). Genome Biol. 7:232, p. 1-13, PMID: 16930467.

Wang M, Liu LH, Wang S, Li X, Lu X, Gupta D, Dziarski R. 2007. Human peptidoglycan recognition proteins require zinc to kill both Gram-positive and Gram-negative bacteria and are synergistic with antibacterial peptides. J. Immunol. 178: 3116-3125, PMID: 17312159.

Li X, Wang S, Qi J, Echtenkamp SF, Chatterjee R, Wang M, Boons G-B, Dziarski R, Gupta D. 2007. Zebrafish peptidoglycan recognition proteins are bactericidal amidases essential for defense against bacterial infections. Immunity 27: 518-529 (featured in an Immunity editorial), PMID: 17892854.

Royet J, Dziarski R. 2007. Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defenses. Nature Rev Microbiol. 5:264-277. PMID: 17363965.

Saha S, Qi J, Wang S, Wang, M, Li X, Kim Y-G, Núñez G, Gupta D, Dziarski R. 2009. PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Cell Host & Microbe 5: 137-150 (featured in a CHM editorial), PMID: 19218085.

Saha S, Jing X, Park SY, Wang S, Li X, Gupta D, Dziarski R. 2010. Peptidoglycan Recognition Proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-?. Cell Host & Microbe 8: 147-162 (featured on the cover and in a CHM editorial), PMID: 20709292.

Kashyap DR, Wang M, Liu L-H, Boons, G-J, Gupta D, Dziarski R. 2011. Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems. Nature Med. 17: 676-683 (featured in a Nature Med. editorial), PMID: 21602801.

Park SY, Gupta D, Kim CH, Dziarski R. 2011. Differential effects of peptidoglycan recognition proteins on experimental atopic and contact dermatitis mediated by Treg and Th17 cells. PLoS One, 6: e24961.  p. 1-16, PMID: 21949809.

Park SY, Gupta D, Hurwich R, Kim CH, Dziarski R. 2011. Peptidoglycan recognition protein Pglyrp2 protects mice from psoriasis-like skin inflammation by promoting regulatory T cells and limiting Th17 responses. J. Immunol. 187: 5813-5823, PMID: 22048773.

Royet J, Gupta D, Dziarski R. 2011. Peptidoglycan recognition proteins: modulators of the microbiome and inflammation. Nature Rev Immunol. 11:837-851, PMID: 22076558.

Park SY, Jing X, Gupta D, Dziarski R. 2013. Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses. J. Immunol. 190: 3480-3492, PMID: 23420883.

Zulfiqar F, Hozo I, Rangarajan S, Mariuzza R, Dziarski R, Gupta D. 2013. Genetic association of peptidoglycan recognition protein variants with inflammatory bowel disease. PLoS One, 8(6):e67393. p. 1-14, PMID: 23840689.

Dziarski R. 2013. Innate immunity.  In: Schaechter’s Mechanisms of Microbial Disease, 5th Edition, Engelberg NC, DiRita V, Dermody TS (eds), Chapter 6, Wolters Kluwer/Lippincott, Williams & Wilkins, pp 66-90.

Kashyap DR, Rompca A, Gaballa A, Helmann JD, Chan J, Chang CJ, Hozo I, Gupta D, Dziarski R. 2014. Peptidoglycan recognition proteins kill bacteria by inducing oxidative, thiol, and metal stress. PLoS Pathog. 10:e1004280. p. 1-17, PMID: 25032698.

Jing X, Zulfiqar F, Park SY, Núñez G, Dziarski R, Gupta D. 2014. Peptidoglycan recognition protein 3 and Nod2 synergistically protect mice from dextran sodium sulfate-induced colitis. J Immunol. 193: 3055-3069, PMID: 25114103.

Dziarski R, Park SY, Kashyap DR, Dowd SE, Gupta D. 2016. Pglyrp-regulated gut microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii enhance and Alistipes finegoldii attenuates colitis in mice. PLoS One, 11(1): e0146162. p. 1-24, PMID: 26727498.

Dziarski R, Royet J, Gupta D. 2016. Peptidoglycan Recognition Proteins (PGRPs) and Lysozyme. In: Encyclopedia of Immunobiology, Ratcliffe MJH (ed), Academic Press/Elsevier Ltd, vol. 2, pp. 389-403, ISBN-13: 978-0123742797

Rodriguez-Nunez I, Caluag T, Kirby K, Rudick CN, Dziarski R, Gupta D. 2017. Nod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction. Scientific Reports, 7: 548, p. 1-18, DOI:10.1038/s41598-017-00484-2

Kashyap DR, Kuzma M, Kowalczyk DA, Gupta D, Dziarski R. 2017. Bactericidal peptidoglycan recognition protein induces oxidative stress in Escherichia coli through a block in respiratory chain and increase in central carbon catabolism. Mol Microbiol, DOI: 10.1111/mmi.13733

Dziarski R, Gupta D. 2017. How innate immunity proteins kill bacteria and why they are not prone to resistance. Curr Genetics, DOI: 10.1007/s00294-017-0737-0

See PubMed for complete list of publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=dziarski

Key Publications

Saha S, Qi J, Wang S, Wang, M, Li X, Kim Y-G, Núñez G, Gupta D, Dziarski R. 2009. PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Cell Host & Microbe 5: 137-150. PMID: 19218085.   

Saha S, Jing X, Park SY, Wang S, Li X, Gupta D, Dziarski R. 2010. Peptidoglycan Recognition Proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-γ. Cell Host & Microbe 8: 147-162. PMID: 20709292.

Kashyap DR, Wang M, Liu L-H, Boons, G-J, Gupta D, Dziarski R. 2011. Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems. Nature Med. 17: 676-683. PMID: 21602801.

Royet J, Gupta D, Dziarski R. 2011. Peptidoglycan recognition proteins: modulators of the microbiome and inflammation. Nature Rev Immunol. 11:837-851. PMID: 22076558.

Kashyap DR, Rompca A, Gaballa A, Helmann JD, Chan J, Chang CJ, Hozo I, Gupta D, Dziarski R. 2014. Peptidoglycan recognition proteins kill bacteria by inducing oxidative, thiol, and metal stress. PLoS Pathog. 10:e1004280. p. 1-17. PMID: 25032698.

Rodriguez-Nunez I, Caluag T, Kirby K, Rudick CN, Dziarski R, Gupta D. 2017. Nod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction. Scientific Reports, 7: 548, p. 1-18, DOI:10.1038/s41598-017-00484-2

Kashyap DR, Kuzma M, Kowalczyk DA, Gupta D, Dziarski R. 2017. Bactericidal peptidoglycan recognition protein induces oxidative stress in Escherichia coli through a block in respiratory chain and increase in central carbon catabolism. Mol Microbiol, DOI: 10.1111/mmi.13733

Connect


rdziar@iun.edu 


219-980-6535 


Indiana University School of Medicine Northwest-Gary
DUNES MED/PROF 3018 MEDN
North West, IN 46408