Bart Pederson, PhD

Associate Professor


Research Interests

My laboratory is broadly interested in glucose metabolism. Specifically, we are studying the role of the storage form of glucose, glycogen, in various tissues.

We have mice genetically engineered to lack or overaccumulate glycogen in several tissues. We are studying these animals to better understand the importance of glycogen in organ development and function, as well as in diseases such as diabetes and epilepsy.

Representative publications:

Pederson, B. A., Turnbull, J., Epp, J. R., Weaver, S. A., Zhao, X., Pencea, N., Roach, P. J., Frankland, P. W., Ackerley, C. A. and Minassian, B. A. (2013), Inhibiting glycogen synthesis prevents lafora disease in a mouse model. Annals of Neurology, 74: 297–300. Abstract | Full Text

Canada, S.E., Weaver, S.A., Sharpe, S.N, and Pederson, B.A. (2011) Brain glycogen supercompensation in the mouse after recovery from insulin-induced hypoglycemia. J. Neurosci. Res. 89, 585-591. Abstract | Full Text

Savage, D.B., Zhai, L., Ravikumar, B., Choi, C.S., Snaar, JEM., Medina-Gomez, G. Kim, S., McGuire, A.C., Wou, S-E., Bock, C.B., Evans, R.M., Vidal-Puig, A., Barroso, I., Shulman, G.U., Karpe, F., Taylor, R., Pederson, B.A., Roach, P.J., O'Rahilly, S., DePaoli-Roach, A.A. (2008) A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. PLOS-Medicine. 5, e2. PMC2214798 | Abstract | Full Text | Supplementary Material | Correction |

Pederson, B.A., Schroeder, J.M., Parker, G.E., Smith, M.W., Depaoli-Roach, A.A., Roach, P.J. (2005) Glucose metabolism in mice lacking muscle glycogen synthase. Diabetes ,54, 3466-3473. Abstract | Full Text

Pederson, B.A., Cope, C.R., Irimia, J.M., Schroeder, J.M., Thurberg, B.L., Depaoli-Roach, A.A., Roach, P.J. (2005) Mice with elevated muscle glycogen stores do not have improved exercise performance. Biochem. Biophys. Res. Commun. 331, 491-496. Abstract

Pederson, B.A., Cope, C.R., Schroeder, J.M., Smith, M.W., Irimia, J.M., Thurberg, B.L., Depaoli-Roach, A.A., Roach, P.J. (2005) Exercise capacity of mice genetically lacking muscle glycogen synthase: In mice, muscle glycogen is not essential for exercise. J. Biol. Chem. 280, 17260-17265. Abstract | Full Text | Full Text (PDF)

Pederson, B.A., Chen, H., Schroeder, J.M., Shou, W., Depaoli-Roach, A.A., Roach, P.J. (2004) Abnormal cardiac development in the absence of heart glycogen. Mol.Cell. Biol. 24, 7179-7187. Abstract | Full Text | Full Text (PDF)

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